Evoked response probe and method of use
A therapeutic effect assessment system, including: a probe shaped and sized to be inserted into a brain of a subject, having a proximal end and a distal end and a longitudinal axis, the probe including a plurality of contacts operably coupled thereto, disposed along the longitudinal axis, wherein the probe is selectively operable for stimulating an electrophysiological evoked responses; at least one electrode configured to record readings of evoked responses caused by the stimulating; and an analysis module electrically connected to the probe and to the at least one electrode, wherein the analysis module is configured to transform or reduce certain parameters from the recorded readings of evoked responses in order to identify a threshold of brain stimulation that produces a therapeutic effect.
1. A therapeutic effect assessment system, comprising:
a. a deep brain stimulation (DBS) probe shaped and sized to be inserted into a brain of a subject, having a proximal end and a distal end and a longitudinal axis, the probe comprising a plurality of contacts operably coupled thereto, disposed along the longitudinal axis, wherein said DBS probe is selectively operable for stimulating electrophysiological evoked responses, and for delivery of a DBS treatment using at least two contacts disposed along the longitudinal axis of said DBS probe;
b. at least one electrode configured to record brain electrical signals generated in response to said stimulated electrophysiological evoked responses caused by said stimulating; and
c. an analysis module electrically connected to said probe and to said at least one electrode, wherein said analysis module is configured to transform or reduce certain parameters from the recorded brain electrical signals generated in response to said electrophysiological evoked responses caused by said stimulating using said at least two contacts using a stimulation threshold, in order to identify a clinical therapeutic threshold of brain stimulation that produces a clinical therapeutic effect of said DBS treatment when using said at least two contacts;
wherein said analysis module is further configured for mapping functional brain regions along an insertion path of said DBS probe;
identifying a motor or a sensory brain region along said insertion path based on said mapping;
wherein said stimulating comprises stimulating said identified motor or sensory brain region using said stimulation threshold using said at least two contacts of said DBS probe.
2. A system according to claim 1 , wherein said certain parameters comprise one or more of RMS, Normalized RMS, power density of different frequency bands, firing rates, and inter spike intervals.
3. A system according to claim 1 , wherein said system is operative for providing segmentation of the brain into a plurality of physiologically active brain regions based on signals recorded by said at least one electrode.
4. A system according to claim 1 , wherein said at least one electrode is positioned on said DBS probe.
5. A system according to claim 1 , wherein stimulating electrophysiological evoked response comprises stimulating unipolar signal, bipolar signal or both unipolar and a bipolar signal, and wherein said recording said brain electrical signals comprises recording single ended signal, or differential signal.
6. A system according to claim 1 , wherein at least two of the plurality of contacts of said first probe are macro-contacts configured to selectively perform localized stimulation.
7. A system according to claim 6 , wherein localized stimulation is configured to take place between two adjacent macro-contacts of said first probe.
8. A system according to claim 1 , wherein said analysis module is operative for providing segmentation of the brain into a plurality of physiologically active brain regions based on said brain electrical signals recorded by said at least one electrode.
9. A system according to claim 1 , wherein said probe is shaped as a needle.
10. A system according to claim 1 , wherein said analysis module is configured to transform or reduce certain parameters from the recorded brain electrical signals in order to establish a clinical therapeutically effective window of said DBS treatment.
11. A system according to claim 1 , wherein said brain electrical signals recorded by said at least one electrode comprise readings of brain evoked responses generated in response to said stimulated electrophysiological evoked responses using said stimulation threshold.
12. A method for assessing a therapeutic effect of brain stimulation in a subject, comprising:
inserting the DBS probe of claim 1 along an insertion path into the brain of a subject;
stimulating a brain region at a first location using a stimulation threshold using at least two contacts of said DBS probe disposed along the longitudinal axis of the DBS probe, in a manner suitable to evoke an electrophysiological response;
recording in a second location brain electrical signals generated in response to said stimulated electrophysiological evoked responses caused by said stimulating;
analyzing the recorded electrical signals;
identifying a clinical therapeutic threshold of brain stimulation that establishes a clinical therapeutically effective window of said DBS treatment when using said at least two contacts for delivery of said DBS treatment, based on said analysis results;
wherein said method further comprises mapping functional brain regions along said insertion path of said DBS probe;
identifying a motor or a sensory brain region along said insertion path based on said mapping;
wherein said stimulating comprises stimulating said identified motor or sensory brain region using said stimulation threshold using said at least two contacts of said DBS probe.
13. A method according to claim 12 , wherein said analyzing comprises reducing or transforming certain parameters from said recorded brain electrical signals.
14. A method according to claim 12 , wherein said brain electrical signals recorded in said second location comprise readings of a brain evoked electrophysiological response.