Compositions and methods for promoting hair growth with Mpc1 inhibitors
Provided herein are methods of accelerating, promoting, or restoring hair growth, comprising administering to a subject in need thereof an effective amount of a compound of formula (I). Also provided are compositions comprising the compound of formula (I).
1. A method of accelerating, promoting, or restoring hair growth, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein administering comprises topically applying a composition comprising the compound to an affected area.
3. The method of claim 1 , wherein the subject exhibits symptoms selected from alopecia, hair loss, hair thinning, and baldness.
4. The method of claim 1 , wherein the subject exhibits symptoms selected from hair loss, hair thinning, and baldness.
5. The method of claim 1 , wherein the subject exhibits baldness.
6. The method of claim 5 , wherein the baldness is male pattern baldness or female pattern baldness.
7. The method of claim 1 , wherein the subject exhibits symptoms selected from hair loss and hair thinning.
8. The method of claim 7 , wherein the hair loss or the hair thinning is caused by anagen effluvium or telogen effluvium.
9. The method of claim 3 , wherein the alopecia is selected from juvenile alopecia, premature alopecia, senile alopecia, alopecia areata, androgenic alopecia, mechanical alopecia, and symptomatic alopecia.
10. The method of claim 1 , wherein the compound is applied to a hair follicle.
11. The method of claim 1 , wherein the compound of formula (I) is administered daily.
12. The method of claim 1 , wherein the subject is a mammal.
13. The method of claim 1 , wherein the subject is a human.
14. The method of claim 1 , wherein: administering comprises topically applying a composition comprising the compound to an affected area; the subject exhibits symptoms selected from alopecia, hair loss, hair thinning, and baldness; and the subject is human.
15. The method of claim 14 , wherein the subject exhibits symptoms of baldness.
16. The method of claim 15 , wherein the baldness is male pattern baldness or female pattern baldness.
17. The method of claim 14 , wherein the subject exhibits symptoms of alopecia.
18. The method of claim 17 , wherein the alopecia is selected from juvenile alopecia, premature alopecia, senile alopecia, alopecia areata, androgenic alopecia, mechanical alopecia, and symptomatic alopecia.
19. The method of claim 14 , wherein the subject exhibits symptoms selected from hair loss and hair thinning.
20. The method of claim 19 , wherein the hair loss or the hair thinning is caused by anagen effluvium or telogen effluvium.