IP Library › Granted Patent US 12,649,736
Granted Patent B2
US 12,649,736 · App. 17/786,986 · Granted Jun 9, 2026

Synthesis of compounds to promote hair growth

Inventors: Michael E. Jung (Los Angeles, CA); Xiaoguang Liu (Santa Monica, CA)
Assignee: The Regents of the University of California
C07D471/04
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Quick Facts
Patent No.
US 12,649,736
App. No.
17/786,986
Granted
Jun 9, 2026
Kind
B2
Abstract

The present disclosure relates to a method of synthesizing a compound represented by formula I.

Claims (19)

1 . A method for the preparation of a compound having the following structure:

or a pharmaceutically acceptable salt thereof;

said method comprising:

reacting

with an acylation reagent to produce

reacting

with

to produce

and

further hydrolyzing

to produce

2 . The method of claim 1 , further comprising reacting

with

to produce

wherein W is a leaving group.

3 . The method of claim 2 , wherein W is halo.

4 . The method of claim 2 , wherein W is bromo.

5 . The method of claim 1 , wherein hydrolyzing compound 4 produces JXL069 in more than 90% yield.

6 . The method of claim 1 , wherein hydrolyzing compound 4 produces JXL069 in 95% yield.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 21, 2026
From: SUN, DANIEL L.
To: PELAGE PHARMACEUTICALS, INC.
Reel/Frame 075341/0491 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2023
From: JUNG, MICHAEL E.; LIU, XIAOGUANG
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 063723/0278 →
Continuity (2)
Provisional Application 62951667 · Dec 20, 2019
Related Publication 20230103693A1 · Apr 6, 2023
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