Granted Patent B2

US 12,559,490 · App. 18/013,803 · Granted Feb 24, 2026

Inventors: Daniel L. Sun (Los Angeles, CA); Michael E. Jung (Los Angeles, CA); Daniel W. Gil (Los Angeles, CA)

Assignees: The Regents of the University of California; Pelage Pharmaceuticals, Inc.

C07D471/04

Abstract

Claims (26)

1 . A compound represented by a formula:

or a pharmaceutically acceptable salt thereof;

wherein R 1 is -, —S(═O) 2 —, an optionally substituted C 1-12 hydrocarbon group or an optionally substituted heterocycle;

R 2 is H, an optionally substituted C 1-6 alkyl, an optionally substituted carbocycle, or an optionally substituted heterocycle;

 and

R 6 is:

2 . The compound of claim 1 , wherein R 6 is:

3 . The compound of claim 1 , wherein R 1 is -, —CH 2 —, an optionally substituted C 3-12 hydrocarbon group, or an optionally substituted heterocycle having a carbon atom directly attached to the O atom.

4 . The compound of claim 1 , wherein R 1 is an optionally substituted C 1-12 alkyl.

5 . The compound of claim 1 , wherein R 1 is an optionally substituted heterocycle.

6 . The compound of claim 1 , wherein R 1 is an optionally substituted aryl.

7 . The compound of claim 1 , wherein R 1 is an optionally substituted benzyl.

8 . The compound of claim 1 , wherein R 1 is an optionally substituted oxetane, optionally substituted dihydrofuran, optionally substituted furan, optionally substituted furanone, optionally substituted tetrahydropyran, optionally substituted dihydropyran, optionally substituted pyran, optionally substituted tetrahydropyrone, optionally substituted dihydropyrone, optionally substituted thietane, optionally substituted tetrahydrothiophene, optionally substituted dihydrothiophene, optionally substituted thiophene, optionally substituted azetidine, optionally substituted pyrrolidine, optionally substituted pyrroline, optionally substituted pyrrole, optionally substituted piperidine, optionally substituted pyridine, optionally substituted oxazole, optionally substituted isoxazole, optionally substituted thiazole, optionally substituted isothiazole, optionally substituted pyrazolidine, optionally substituted imidazolidine, optionally substituted pyrazole, optionally substituted imidazole, optionally substituted tetrazole, or optionally substituted sulfolane.

9 . The compound of claim 1 , wherein Y is -.

10 . The compound of claim 1 , wherein Y is —O—.

11 . The compound of claim 1 , wherein Y is

12 . The compound of claim 1 , wherein Y is

13 . The compound of claim 1 , wherein Y is

14 . The compound of claim 1 , wherein R 2 is H.

15 . The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

16 . The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

17 . The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

18 . A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.

Assignments (2)

Continuity (2)

References Cited (216)