Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder
The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, a cofactor of the enzyme, and a glucan. The present disclosure also relates to the synergistic combination of sulforaphane or a derivative thereof and a glucan. The present disclosure also relates to the synergistic combination of a broccoli extract or powder and a glucan. The glucan may be a β-glucan. The glucan may be provided in a mushroom extract or powder selected from one or more of a maitake, a shiitake, or a reishi mushroom. Compositions and methods relating to these combinations are described.
1. An orally administrable composition comprising a synergistic combination of:
a sulforaphane precursor;
a glucosidase enzyme capable of converting the sulforaphane precursor to sulforaphane;
a glucosidase enzyme cofactor; and
a glucan;
the combination having a ratio of sulforaphane precursor:glucan of from about 50:1 to about 1:50.
2. The orally administrable composition of claim 1 , wherein the sulforaphane precursor comprises glucoraphanin, the glucosidase enzyme comprises myrosinase, and the glucosidase enzyme cofactor comprises ascorbic acid.
3. The orally administrable composition of claim 1 , wherein the composition comprises an enteric-coated dosage form.
4. The orally administrable composition of claim 1 , wherein the composition comprises a mushroom extract or powder comprising the glucan.
5. The orally administrable composition of claim 1 , wherein the composition comprises a yeast extract or powder comprising the glucan.
6. The orally administrable composition of claim 1 , wherein the glucan is a β-glucan.
7. The orally administrable composition of claim 1 , wherein the glucan is an α-glucan.
8. The orally administrable composition of claim 4 , wherein the mushroom extract or powder is derived from one or more of a maitake mushroom, a shiitake mushroom, and a reishi mushroom.
9. The orally administrable composition of claim 5 , wherein the yeast extract or powder is derived from a baker's yeast.
10. The orally administrable composition of claim 1 , wherein the composition further comprises one or more additional components selected from the group consisting of quercetin, an aminosugar, a glycosaminoglycan, avocado/soybean unsaponifiables, a vitamin, a coffee fruit, magnesium, silymarin, proanthocyanidins, ursolic acid, curcumin, phytosterols, and phytostanols.
11. The orally administrable composition of claim 1 , wherein the composition comprises glucoraphanin, myrosinase, ascorbic acid, and β-glucan.
12. The orally administrable composition of claim 1 , wherein the composition comprises glucoraphanin, myrosinase, ascorbic acid, and α-glucan.
13. The orally administrable composition of claim 8 , wherein the composition comprises glucoraphanin, myrosinase, ascorbic acid, and maitake mushroom extract or powder.
14. The orally administrable composition of claim 8 , wherein the composition comprises glucoraphanin, myrosinase, ascorbic acid, maitake mushroom extract or powder, and shiitake mushroom extract or powder.
15. The orally administrable composition of claim 1 , wherein the composition comprises a broccoli extract or powder comprising the sulforaphane precursor.
16. An orally administrable composition comprising a synergistic combination of:
a sulforaphane or sulforaphane derivative; and
a glucan;
the combination having a ratio of sulforaphane or sulforaphane derivative:glucan of from about 50:1 to about 1:50.
17. The orally administrable composition of claim 16 , wherein the composition comprises an enteric-coated dosage form.
18. The orally administrable composition of claim 16 , wherein the composition comprises a mushroom extract or powder comprising the glucan.
19. The orally administrable composition of claim 16 , wherein the composition comprises a yeast extract or powder comprising the glucan.
20. The orally administrable composition of claim 16 , wherein the glucan is a β-glucan.
21. The orally administrable composition of claim 16 , wherein the glucan is an α-glucan.
22. The orally administrable composition of claim 18 , wherein the mushroom extract or powder is derived from one or more of a maitake mushroom, a shiitake mushroom, and a reishi mushroom.
23. The orally administrable composition of claim 19 , wherein the yeast extract or powder is derived from a baker's yeast.
24. The orally administrable composition of claim 16 , wherein the composition further comprises one or more additional components selected from the group consisting of quercetin, an aminosugar, a glycosaminoglycan, avocado/soybean unsaponifiables, a vitamin, a coffee fruit, magnesium, silymarin, proanthocyanidins, ursolic acid, curcumin, phytosterols, and phytostanols.
25. The orally administrable composition of claim 16 , comprising sulforaphane or sulforaphane derivative and β-glucan.
26. The orally administrable composition of claim 16 , comprising sulforaphane or sulforaphane derivative and α-glucan.
27. The orally administrable composition of claim 22 , wherein the composition comprises sulforaphane or sulforaphane derivative and maitake mushroom extract or powder.
28. The orally administrable composition of claim 22 , wherein the composition comprises sulforaphane or sulforaphane derivative, maitake mushroom extract or powder, and shiitake mushroom extract or powder.
29. The orally administrable composition of claim 16 , wherein the composition comprises a broccoli extract or powder comprising the sulforaphane or sulforaphane derivative.