IP Library › Granted Patent US 12,648,979
Granted Patent B2
US 12,648,979 · App. 17/825,438 · Granted Jun 9, 2026

Compositions comprising sulforaphane or a sulforaphane precursor and

Inventors: Robert Henderson (Lancaster, SC); Brian Cornblatt (Lancaster, SC)
Assignee: Nutramax Laboratories, Inc.
A61K36/185A61K31/26A61K36/06A61K36/07A61K36/31A61P35/00C12N9/2402C12Y302/01147
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Quick Facts
Patent No.
US 12,648,979
App. No.
17/825,438
Granted
Jun 9, 2026
Kind
B2
Abstract

A composition including a Moringa plant component for treating, preventing, reducing the occurrence of, decreasing the symptoms associated with, and/or reducing secondary recurrences of cancer in a subject is provided. The composition may comprise a Moringa plant component in an amount of 1 mg to 1750 mg, and sulforaphane or a sulforaphane derivative in an amount of 1 mg to 50 mg. Alternatively, the composition may comprise a Moringa plant component in an amount of 150 mg to 1500 mg sulforaphane precursor in an amount of 1 mg to 50 mg. The Moringa plant component can be Moringa leaf extract containing 10 mg of moringin per 1000 mg of the Moringa leaf extract. The composition may also include at least one of a mushroom extract or powder and a broccoli extract or powder.

Claims (18)

1 . A composition comprising:

a Moringa plant component in an amount of 1 milligram (mg) to 1750 mg; and

a sulforaphane derivative in an amount of 1 mg to 50 mg, wherein the sulforaphane derivative includes at least one of sulfoxythiocarbamate analogues of sulforaphane and 6-methylsulfinylhexyl isothiocyanate (6-HITC);

wherein the Moringa plant component and the sulforaphane derivative are present in amounts synergistically effective to increase gene expression of heme oxygenase-1 (HMOX1) or gene expression of Nrf2-regulated NAD(P)H:quinone dehydrogenase 1 (NQO1) in a subject.

2 . A composition according to claim 1 including the Moringa plant component in an amount of 100 mg to 100 mg; and the sulforaphane derivative in an amount of 1 mg to 15 mg.

3 . A composition according to claim 1 , wherein the Moringa plant component is Moringa leaf extract containing 10 mg of moringin per 1000 mg of the Moringa leaf extract.

4 . A composition according to claim 1 further comprising a mushroom extract or powder.

5 . A composition according to claim 1 further comprising a broccoli extract or powder.

6 . A composition comprising:

a Moringa plant component an amount of 150 to 1500 mg; and

a sulforaphane precursor in an amount of 1 to 100 mg, wherein the sulforaphane precursor is glucoraphanin;

wherein the Moringa plant component and the sulforaphane precursor are present in amounts synergistically effective to increase gene expression of heme oxygenase-1 (HMOX1) or gene expression of Nrf2-regulated NAD(P)H:quinone dehydrogenase 1 (NQO1) in a subject.

7 . A composition according to claim 6 , wherein the Moringa plant component is Moringa leaf extract containing 10 mg of moringin per 1000 mg of the Moringa leaf extract.

8 . A composition according to claim 6 , wherein the Moringa plant component includes a glucosidase enzyme capable of converting the sulforaphane precursor to sulforaphane.

9 . A composition according to claim 8 , wherein the glucosidase enzyme is a thioglucosidase enzyme.

10 . A composition according to claim 9 , wherein the thioglucosidase enzyme is myrosmase.

11 . A composition according to claim 6 further comprising a mushroom extract or powder.

12 . A composition according to claim 6 further comprising a broccoli extract or powder.

Continuity (3)
Provisional Application 63193254 · May 26, 2021
Provisional Application 63193270 · May 26, 2021
Related Publication 20220387535A1 · Dec 8, 2022
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