Compositions comprising sulfated polysaccharides and uses thereof
The present invention relates to a composition for intravaginal and/or for internal mucosal application, comprising an effective amount of a sulfated polysaccharide, one or more of a natural quaternary polymer, a quaternary molecular compound, a metalloproteinase inhibitor, one or more anti-inflammatory agent, an acid pH control buffering system or any combination thereof, and a pharmaceutically acceptable carrier. The invention is further related to a method of treating or alleviating vaginal infection, vaginal dryness, vaginal or vulvo vaginal atrophy, vaginal itching, dyspareunia, vaginal or vulvar pain, vaginal or perivaginal inflammation or for promoting vaginal or wound healing, vaginal atrophy/dryness caused by radiotherapy, chemotherapy and/or hormonal treatment and decreased vaginal boundary lubrication or a disease or condition associated therewith or of improving vaginal boundary lubrication.
1. A composition for intravaginal application, comprising 0.1% w/w fucoidan, 0.2% w/w prasinococcus capsulatus polysaccharide, 0.1 w/w porphyridium polysaccharide, 0.1% w/w chitosan, an acid pH control buffering system, a pharmaceutically acceptable carrier, and 0.1% w/w guar hydroxypropyltrimonium chloride, wherein the composition is in the form of a gel wherein the porphyridium polysaccharide consists of exo-polysaccharides derived from a porphyridium algae and wherein the prasinococcus capsulatus polysaccharide consists of exo-polysaccharides derived from a prasinococcus capsulatus algae.
2. The composition of claim 1 , wherein said acid pH control buffering system is lactic acid, sodium dibasic hydrogen phosphate, sodium lactate, citric acid, or any combination thereof.
3. The composition of claim 1 , wherein the composition further comprises one or more of saccharide isomerate as a moisturizing agent, and ethylenediaminetetraacetic acid (EDTA) as a chelating agent.
4. The composition of claim 1 , wherein the composition further comprises one or more of extract of Chondrus Chrispus , Xanthan gum, caprylhydroxamic acid, caprylyl glycol, glycerin, undecylenic acid, monoester of caprylic acid, an extract of any one of echinaccea, propolis, comfrey, melissa, grape fruit, mango seed, cranberry, cucumber, salvia, Chamomile, Geranium, lavender, lemon, juniper, clove bud, lotus, moringa, Grape seed or Gotu Kola ( Centella asiatica extracts) or any combination thereof.
5. The composition of claim 1 , wherein said composition further comprises one or more of an antimicrobial, an antiviral, an antifungal, an anti-inflammatory, anti-irritating, anti-itching, growth factor, a hormone or a spermicidal compound.
6. The composition according to claim 1 , wherein said composition further comprises one or more anti inflammatory agents.