Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder
The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The invention also relates to the combination of sulforaphane or a derivative thereof and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present invention also relates to the combination of a broccoli extract or powder and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present provides compositions and methods relating to these combinations.
1. An orally administrable composition comprising a broccoli extract or powder and one or both of a maitake and a shiitake mushroom extract or powder, the orally administrable composition being formulated to provide synergistically effective amounts of one or both of a sulforaphane and a sulforaphane precursor and one or more glucans, wherein the one or both of the sulforphane and the sulforaphane precursor and one or more glucans are provided to a subject in need thereof in amounts synergistically effective to at least increase levels and/or gene expression of NAD(P)H:quinone oxidoreductase 1 (NQO-1).
2. The orally administrable composition of claim 1 , wherein the broccoli extract or powder comprises glucoraphanin in an amount of about 1 to about 75% w/w.
3. The orally administrable composition of claim 1 , wherein the broccoli extract or powder comprises myrosinase.
4. The orally administrable composition of claim 1 , further comprising an enzyme potentiator.
5. The orally administrable composition of claim 1 , wherein the enzyme potentiator comprises ascorbic acid.
6. The orally administrable composition of claim 1 , wherein the composition comprises an enteric dosage form.
7. The orally administrable composition of claim 1 , comprising a maitake mushroom extract or powder comprising beta-glucan.
8. The orally administrable composition of claim 1 , comprising a shiitake mushroom extract or powder comprising alpha-glucan.
9. The orally administrable composition of claim 1 , comprising a maitake mushroom extract or powder and a shiitake mushroom extract or powder.