Chlorogenic acid composition for the treatment of Alzheimer's disease
The invention provides compositions comprising chlorogenic acid and methods for their use and manufacture in the treatment of Alzheimer's disease. The compositions can be formulated from botanical sources of chlorogenic acid including sunflower seed extract.
1. A composition for treating Alzheimer's disease, comprising a mixture of chlorogenic acids that consists of 4.1±1.42 w/w % 3-Caffeoylquinic acid (3-CQA), 28±4.65 w/w % 5-Caffeoylquinic acid (5-CQA), 6.5±2.25 w/w % 4-Caffeoylquinic acid (4-CQA), 0.84±0.26 w/w % 3,4-Dicaffeoylquinic acid (3,4-DiCQA), 1.23±0.34 w/w % 3,5-Dicaffeoylquinic acid (3,5-DiCQA), and 1.85±0.42 w/w % 4,5-Dicaffeoylquinic acid (4,5-DiCQA), wherein the composition further comprises an artificial pharmaceutical carrier.
2. The composition of claim 1 , wherein said mixture is a sunflower seed extract.
3. The composition of claim 1 , wherein said composition has a DPPH IC50 value of about 38.49 μg/mL in vitro.
4. The composition of claim 1 , wherein said composition has an acetylcholinesterase IC50 value of about 43 μs/mL in vitro.
5. The composition of claim 1 , wherein said composition is in a form selected from the group consisting of a powder, liquid, pill, tablet, pellet, capsule, thin film, solution, spray, syrup, linctus, lozenge, pastille, chewing gum, paste, vapor, suspension, emulsion, ointment, cream, lotion, liniment, gel, drop, topical patch, buccal patch, bead, gummy, gel, sol, and injectable solution.