IP Library › Granted Patent US 12,280,030
Granted Patent B2
US 12,280,030 · App. 17/227,296 · Granted Apr 22, 2025

Method of using a chlorogenic acid composition for supporting cognitive function

Inventor: Kodimule Shyam Prasad (Bangalore, IN)
Assignee: Vidya Herbs, Inc.
A61K31/216A61K9/0053A61K36/28A61P25/28
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Quick Facts
Patent No.
US 12,280,030
App. No.
17/227,296
Filed
Apr 10, 2021
Granted
Apr 22, 2025
Kind
B2
Art Unit
1675
USPC
424/48
Abstract

The invention provides compositions comprising chlorogenic acid and methods for their use and manufacture in the treatment of Alzheimer's disease. The compositions can be formulated from botanical sources of chlorogenic acid including sunflower seed extract.

Claims (12)

1. A method for promoting cognitive function, comprising administering to a person in need thereof an effective amount of a composition comprising sunflower seed extract obtained from aqueous extraction of sunflower seeds, wherein said extract comprises a mixture of chlorogenic acids consisting of 4.1±1.42% w/w 3-Caffeoylquinic acid (3-CQA), 28±4.65% w/w 5-Caffeoylquinic acid (5-CQA), 6.5±2.25% w/w 4-Caffeoylquinic acid (4-CQA), 0.84±0.26% w/w 3,4-Dicaffeoylquinic acid (3,4-DiCQA), 1.23±0.34% w/w 3,5-Dicaffeoylquinic acid (3,5-DiCQA), and 1.85±0.42% w/w 4,5-Dicaffeoylquinic acid (4,5-DiCQA).

2. The method of claim 1 , wherein said composition is administered to said person at a dosage of about 200-400 mg per kilogram body weight.

3. The method of claim 1 , wherein said composition is administered to said person orally.

4. The method of claim 1 , wherein said composition has a DPPH IC50 value of about 38.49 μg/mL in vitro.

5. The method of claim 1 , wherein said composition has an acetylcholinesterase IC50 value of about 43 μg/mL in vitro.

6. The method of claim 1 , wherein said composition is in a form selected from the group consisting of a powder, liquid, pill, tablet, pellet, capsule, thin film, solution, spray, syrup, linctus, lozenge, pastille, chewing gum, paste, vapor, suspension, emulsion, ointment, cream, lotion, liniment, gel, drop, topical patch, buccal patch, bead, gummy, sol, and injectable solution.

7. The method of claim 1 , wherein administering said composition inhibits Tau phosphorylation in said person.

8. The method of claim 1 , wherein administering said composition inhibits the formation of amyloid plaques in said person.

9. The method of claim 1 , wherein administering said composition inhibits the formation of neurofibrillary tangles in said person.

10. The method of claim 1 , wherein administering said composition inhibits the loss of glutathione in said person.

11. The method of claim 1 , wherein administering said composition increases glutathione in said person.

12. The method of claim 1 , wherein said composition further comprises an excipient.

Continuity (4)
Continuation 16777290 · Jan 30, 2020
Continuation 15647192 · Jul 11, 2017
Provisional Application 62361491 · Jul 12, 2016
Related Publication 20210330627A1 · Oct 28, 2021
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