Chlorogenic acid composition for the treatment of metabolic disorders
A composition of chlorogenic acids and method of its use and manufacture in the treatment of metabolic disorders. The composition can be obtained from sunflower seed extract, including Helianthus annulus seeds.
1. A method for treating a metabolic disorder, comprising administering to a patient in need thereof sunflower seed extract comprising a mixture of chlorogenic acids, said mixture comprising 3-CQA; 5-CQA; 4-CQA; 3,4-diCQA; 3,5-diCQA; and 4,5-diCQA.
2. The method of claim 1 , wherein said mixture comprises 4.1±1.42 w/w % 3-CQA, 28±4.65 w/w % 5-CQA, 6.5±2.25 w/w % 4-CQA, 0.84±0.26 w/w % 3,4-diCQA, 1.23±0.34 w/w % 3,5-diCQA, and 1.85±0.42 w/w % 4,5-diCQA.
3. The method of claim 1 , wherein said extract has a total chlorogenic acid content of about 42 w/w %.
4. The method of claim 1 , wherein said extract has a total chlorogenic acid content of 42.50±2.5 w/w %.
5. The method of claim 1 , wherein said extract is Helianthus annuus seed extract.
6. The method of claim 1 , wherein administering said extract reduces at least one of glucose, total lipid content, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triglyceride, Lp(a), apoA-I, apoE, and non-esterified fatty acids in the blood of said patient.
7. The method of claim 1 , wherein said metabolic disorder is selected from the group consisting of prediabetes, diabetes, obesity, dyslipidemia, hyperglycemia, and combinations thereof.
8. The method of claim 1 , wherein said metabolic disorder is type 1 diabetes or type 2 diabetes.
9. The method of claim 1 , wherein said extract is administered systemically.
10. The method of claim 1 , wherein said extract is administered by a route selected from the group consisting of orally, buccally, sub-lingually, parenterally, intravenously, intravaginally, rectally, inhalation, and combinations thereof.
11. The method of claim 1 , wherein said extract is administered orally.
12. The method of claim 1 , wherein said extract is in a form selected from the group consisting of powder, liquid, pill, tablet, pellet, capsule, thin film, solution, spray, syrup, linctus, lozenge, pastille, chewing gum, paste, vapor, suspension, emulsion, ointment, cream, lotion, liniment, gel, drop, topical patch, buccal patch, bead, gummy, gel, sol, and injection.
13. The method of claim 1 , wherein said extract further comprises a vitamin, mineral, extract, amino acid, carbohydrate, lipid, excipient, caffeine, flavoring, sweetener, preservative, or combinations thereof.