IP Library › Granted Patent US 12,522,501
Granted Patent B2
US 12,522,501 · App. 16/875,914 · Granted Jan 13, 2026

Architectures for production of nitric oxide

Inventors: Ian J. Gillerman (Somerville, MA); Benjamin J. Apollonio (Lunenburg, MA); Kevin Cedrone (Boxborough, MA); Ziad F. Elghazzawi (Newton, MA); Gregory W. Hall (Belmont, MA)
Assignee: Third Pole, Inc.
C01B21/24A61M16/12C01B21/203A61M2016/102
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Quick Facts
Patent No.
US 12,522,501
App. No.
16/875,914
Granted
Jan 13, 2026
Kind
B2
Abstract

Architectures for production of nitric oxide (NO) include systems and methods for generating NO having one or more plasma chambers configured to ionize a reactant gas to generate a plasma for producing a product gas containing NO using a flow of the reactant gas through one or more plasma chambers; a controller configured to regulate the amount of nitric oxide in the product gas using one or more parameters as an input to the controller, one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which product gas flows; and a flow divider configured to divide a product gas flow from the plasma chamber into a first product gas flow to provide a variable flow to a patient inspiratory flow and a second product gas flow.

Claims (21)

1 . A nitric oxide (NO) generation system, comprising:

one or more plasma chambers configured to ionize a reactant gas to generate a plasma for producing a product gas containing nitric oxide (NO) using a flow of the reactant gas through the one or more plasma chambers;

a controller configured to regulate an amount of nitric oxide in the product gas using one or more parameters as an input to the controller, the one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and an inspiratory gas into which the product gas flows; and

a flow divider configured to divide a flow of the product gas from the one or more plasma chambers into a first gas flow to provide a flow to the inspiratory gas and a second gas flow to be released into an environment as excess product gas,

wherein the controller is configured to determine an amount of product gas to deliver to the first gas flow such that the first gas flow is in direct proportion to a flow rate of the inspiratory gas, and a flow rate of the second gas flow is a difference between a product gas flow rate from the one or more plasma chambers and a flow rate of the first gas flow.

2 . The nitric oxide (NO) generation system of claim 1 , wherein the second gas flow from the flow divider comprises excess product gas produced by the one or more plasma chambers that includes NO and NO 2 .

3 . The nitric oxide (NO) generation system of claim 2 , wherein the second gas flow is configured to be scrubbed for at least one of NO and NO 2 prior to release into the environment.

4 . The nitric oxide (NO) generation system of claim 2 , wherein the second gas flow is released to a house vacuum.

5 . The nitric oxide (NO) generation system of claim 1 , wherein at least one of the plurality of sensors is a gas sensor configured to measure an NO concentration in the product gas.

6 . The nitric oxide (NO) generation system of claim 5 , wherein the measured NO concentration in the product gas is configured to be used for control of production of the product gas containing NO in the one or more plasma chambers.

7 . The nitric oxide (NO) generation system of claim 1 , wherein at least one of the plurality of sensors comprises an inspiratory flow sensor configured to sense an inspiration of a patient.

8 . The nitric oxide (NO) generation system of claim 7 , wherein a flow rate of product gas configured to be diverted to the patient is proportional to the flow rate of the inspiratory gas.

9 . The nitric oxide (NO) generation system of claim 1 , wherein a gas flow rate through the one or more plasma chambers is constant.

10 . The nitric oxide (NO) generation system of claim 1 , wherein a concentration of product gas at the flow divider is constant.

11 . The nitric oxide (NO) generation system of claim 1 , wherein at least one of the plurality of sensors is a gas sensor configured to measure an NO 2 concentration in the product gas.

12 . The nitric oxide (NO) generation system of claim 1 , wherein the flow divider is comprised of a first flow controller and a second flow controller that are configured to operate to deliver a constant flow rate from the one or more plasma chambers.

13 . A method of generating nitric oxide (NO) comprising:

ionizing a reactant gas inside one or more plasma chambers to generate a plasma for producing a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers, the one or more plasma chambers including at least one pair of electrodes for generating the product gas;

controlling an amount of nitric oxide in the product gas using one or more parameters as input to a control algorithm used by one or more controllers to control the one or more plasma chambers, at least one of the one or more parameters being related to a target concentration of NO in a combination of the product gas and an inspiratory gas into which the product gas flows; and

dividing a flow of the product gas from the one or more plasma chambers into a first gas flow for providing a flow to the inspiratory gas and a second gas flow to be released into an environment as excess product gas by determining a flow rate required for the first gas flow such that the first gas flow is in direct proportion to a flow rate of the inspiratory gas.

14 . The method of claim 13 , wherein the second gas flow is scrubbed for at least one of NO and NO 2 prior to release into the environment.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Mar 19, 2024
From: AVENUE VENTURE OPPORTUNITIES FUND L.P.
To: THIRD POLE, INC.
Reel/Frame 066825/0518 →
SECURITY INTEREST Recorded Mar 18, 2024
From: THIRD POLE, INC.
To: AMERICAN MONEY MANAGEMENT CORPORATION
Reel/Frame 066812/0657 →
SECURITY AGREEMENT Recorded Apr 12, 2021
From: THIRD POLE, INC.
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 055986/0148 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 13, 2020
From: GILLERMAN, IAN J.; APOLLONIO, BENJAMIN J.; CEDRONE, KEVIN; ELGHAZZAWI, ZIAD F.; HALL, GREGORY W.
To: THIRD POLE, INC.
Reel/Frame 053488/0691 →
Continuity (4)
Provisional Application 62959942 · Jan 11, 2020
Provisional Application 62959937 · Jan 11, 2020
Provisional Application 62848530 · May 15, 2019
Related Publication 20200361773A1 · Nov 19, 2020
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