Granted Patent
B2
US 12,419,783 · App. 17/061,372 · Granted Sep 23, 2025
Drug eluting ocular implant
Inventors:
David S. Haffner (San Clemente, CA); Kenneth M. Curry (San Clemente, CA); Harold A. Heitzmann (San Clemente, CA); David Applegate (San Clemente, CA)
Assignee:
Glaukos Corporation
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Abstract
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Claims (30)
1. A method for an intravitreal injection of an agent for the treatment of an ocular disorder, comprising:
advancing to a surface of a sclera of an eye a delivery apparatus comprising:
a proximal end;
a distal end;
a cannula containing one or more micro-tablets,
wherein the one or more micro-tablets have a density of about 0.7 g/cc to about 1.6 g/cc; and
an activator configured to expel the one or more micro-tablets from the cannula of the delivery apparatus via passage through the proximal end;
piercing the surface of the sclera to create a hole in the sclera;
further advancing said delivery apparatus thru said hole such that said proximal end is within a vitreal cavity of the eye;
activating the activator to expel the one or more micro-tablets directly into the eye; and
withdrawing the delivery apparatus from the eye, thereby treating the ocular disorder by delivery of the one or more micro-tablets.
2. The method of claim 1 , wherein piercing of the sclera is performed using an apparatus comprising a sharpened proximal end.
3. The method of claim 1 , wherein the hole in the sclera is sufficiently small to be self-healing.
4. The method of claim 1 , wherein the one or more micro-tablets have a surface area to volume ratio of about 13 to 17.
5. The method of claim 1 , wherein the one or more micro-tablets are coated with a polymeric coating that regulates a release of a therapeutic agent from the one or more micro-tablets.
6. The method of claim 1 , wherein the cannula comprises an inner diameter of about 23 to 25 gauge.
7. The method of claim 1 , wherein the one or more micro-tablets comprise a therapeutic agent having anti-vascular endothelial growth factor (VEGF) effects.
8. The method of claim 1 , wherein the one or more micro-tablets have a minor axis of about 0.28 to 0.31 mm and a major axis of about 0.8 to 1.1 mm.
9. A method for an intravitreal injection of an agent for the treatment of an ocular disorder, comprising:
piercing a surface of a sclera of an eye to create a hole in the surface of the sclera;
advancing a delivery apparatus comprising a cannula containing one or more micro-tablets through the hole, an end of the delivery apparatus being advanced to a vitreal cavity of the eye;
expelling the one or more micro-tablets directly into the eye from the cannula via an activator; and
withdrawing the delivery apparatus from the eye.
10. The method of claim 9 , wherein piercing the surface of the sclera is performed using an apparatus comprising a sharpened end.
11. The method of claim 9 , wherein the hole in the sclera is sufficiently small to be self-healing.
12. The method of claim 9 , wherein the one or more micro-tablets have a surface area to volume ration of about 13 to 17.
13. The method of claim 9 , wherein the cannula comprises an inner diameter of about 23 to 25 gauge.
14. The method of claim 9 , wherein the one or more micro-tablets comprise a therapeutic agent having anti-vascular endothelial growth factor (VEGF) effects.
15. The method of claim 9 , wherein the one or more micro-tablets have a minor axis of about 0.28 to 0.31 mm and a major axis of about 0.8 to 1.1 mm.
16. The method of claim 9 , wherein the one or more micro-tablets are positioned within an implant.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 30, 2025
From: HAFFNER, DAVID; CURRY, KEN; HEITZMANN, HAROLD; APPLEGATE, DAVID
To: DOSE MEDICAL CORPORATION
Reel/Frame 070062/0151 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 30, 2025
From: DOSE MEDICAL CORPORATION
To: GLAUKOS CORPORATION
Reel/Frame 070066/0322 →
Continuity (4)
Continuation
13989037
Provisional Application
61417154
· Nov 24, 2010
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