IP Library › Granted Patent US 12,233,260
Granted Patent B2
US 12,233,260 · App. 17/114,792 · Granted Feb 25, 2025

Electroosmotic tissue treatment

Inventor: Yossi Gross (Moshav Mazor, IL)
Assignee: Discure Technologies Ltd.
A61N1/327A61M27/002A61N1/0536A61N1/306A61N1/36082A61N1/36139
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Quick Facts
Patent No.
US 12,233,260
App. No.
17/114,792
Granted
Feb 25, 2025
Kind
B2
Abstract

Apparatus is provided that includes a first electrode, configured to be implanted at a first anatomical site in a nucleus pulposus of an intervertebral disc of a subject, and a second electrode, configured to be implanted at a second anatomical site outside the nucleus pulposus of the disc. A control unit is configured to detect a pressure difference between the first and the second anatomical sites by detecting a streaming voltage between the first and the second electrodes, and, in response to the detected pressure difference, drive fluid between the nucleus pulposus and outside the nucleus pulposus by applying a treatment voltage between the first and the second electrodes. Other embodiments are also described.

Claims (26)

1. Apparatus comprising:

a first electrode, configured to be implanted at a first anatomical site in a nucleus pulposus of an intervertebral disc of a subject;

a second electrode, configured to be implanted at a second anatomical site outside the nucleus pulposus of the disc; and

a control unit, configured to:

detect a pressure difference between the first and the second anatomical sites by detecting a streaming voltage between the first and the second electrodes, and

in response to the detected pressure difference, drive fluid between the nucleus pulposus and outside the nucleus pulposus by applying a treatment voltage between the first and the second electrodes.

2. The apparatus according to claim 1 , wherein the apparatus is configured not to apply the treatment voltage while detecting the streaming voltage.

3. The apparatus according to claim 1 , wherein the control unit is configured to drive the fluid from the nucleus pulposus to outside the nucleus pulposus.

4. The apparatus according to claim 1 , wherein the control unit is configured to drive the fluid from outside of the nucleus pulposus to the nucleus pulposus.

5. The apparatus according to claim 1 , wherein the control unit is configured to provide a rest period during which the treatment voltage is not applied, and to apply, between the first and the second electrodes, an opposite voltage that is opposite the treatment voltage and that has a lower magnitude than the treatment voltage.

6. The apparatus according to claim 1 , wherein each electrode is insulated such that no portion of the electrode may be in electrical contact with any tissue of the subject, and wherein the control unit is configured to drive a capacitative current between the first and the second insulated electrodes by applying the treatment voltage between the electrodes.

7. A method, comprising:

detecting a pressure difference between a first anatomical site in a nucleus pulposus of an intervertebral disc of a subject and a second anatomical site outside the nucleus pulposus of the disc, by detecting a streaming voltage between the first and the second sites; and

in response to the detected pressure difference, electroosmotically driving fluid between the nucleus pulposus and outside the nucleus pulposus by applying a treatment voltage between the first and the second anatomical sites.

8. The method according to claim 7 , wherein applying the treatment voltage comprises not applying the treatment voltage while detecting the streaming voltage.

9. The method according to claim 7 ,

wherein applying the treatment voltage between the first and the second anatomical sites comprises implanting a first electrode at the first anatomical site, and implanting a second electrode at the second anatomical site, and

wherein applying the treatment voltage between the first and the second anatomical sites comprises applying the treatment voltage between the first and the second electrodes.

10. The method according to claim 9 , wherein detecting the streaming voltage between the first and the second sites comprises detecting the streaming voltage between the first and the second electrodes.

11. The method according to claim 9 ,

wherein implanting the first electrode comprises implanting a first insulated electrode, such that no portion of the first insulated electrode is in electrical contact with any tissue of the subject,

wherein implanting the second electrode comprises implanting a second insulated electrode, such that no portion of the second insulated electrode is in electrical contact with any tissue of the subject, and

wherein applying the treatment voltage comprises driving a capacitative current between the first and the second insulated electrodes.

12. The method according to claim 7 , wherein driving the fluid between the nucleus pulposus and outside the nucleus pulposus comprises driving the fluid from the nucleus pulposus to outside the nucleus pulposus.

13. The method according to claim 7 , wherein driving the fluid between the nucleus pulposus and outside the nucleus pulposus comprises driving the fluid from outside of the nucleus pulposus to the nucleus pulposus.

14. The method according to claim 7 , further comprising providing a rest period during which the treatment voltage is not applied, and applying, during the rest period, an opposite voltage between the first and the second anatomical sites, the opposite voltage opposite the treatment voltage and having a lower magnitude than the treatment voltage.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2022
From: RAINBOW MEDICAL LTD.
To: DISCURE TECHNOLOGIES LTD.
Reel/Frame 059115/0357 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2021
From: GROSS, YOSSI
To: RAINBOW MEDICAL LTD.
Reel/Frame 054948/0181 →
Continuity (3)
Continuation 15618325 · Jun 9, 2017
Continuation 13872794 · Apr 29, 2013
Related Publication 20210106820A1 · Apr 15, 2021
References Cited (160)
US 4044774A · Corbin et al. · 1977 [cited by applicant]
US 4503863A · Katims · 1985 [cited by applicant]
US 5088977A · Sibalis · 1992 [cited by applicant]
US 5121754A · Mullett · 1992 [cited by applicant]
US 5433739A · Sluijter et al. · 1995 [cited by applicant]
US 5529574A · Frackelton · 1996 [cited by applicant]
US 5792100A · Shantha · 1998 [cited by applicant]
US 5911223A · Weaver et al. · 1999 [cited by applicant]
US 5938690A · Law et al. · 1999 [cited by applicant]
US 6041252A · Walker et al. · 2000 [cited by applicant]
US 6146380A · Racz et al. · 2000 [cited by applicant]
US 6161047A · King et al. · 2000 [cited by applicant]
US 6360750B1 · Gerber et al. · 2002 [cited by applicant]
US 6567702B1 · Nekhendzy et al. · 2003 [cited by applicant]
US 6591138B1 · Fischell et al. · 2003 [cited by applicant]
US 6602248B1 · Sharps et al. · 2003 [cited by applicant]
US 6620155B2 · Underwood et al. · 2003 [cited by applicant]
US 6941172B2 · Nachum · 2005 [cited by applicant]
US 6997941B2 · Sharkey et al. · 2006 [cited by applicant]
US 7013177B1 · Whitehurst et al. · 2006 [cited by applicant]
US 7120489B2 · Shalev et al. · 2006 [cited by applicant]
US 7217351B2 · Krumme · 2007 [cited by applicant]
US 7223227B2 · Pflueger · 2007 [cited by applicant]
US 7270659B2 · Ricart et al. · 2007 [cited by applicant]
US 7317947B2 · Wahlstrand et al. · 2008 [cited by applicant]
US 7398121B2 · Matsumura et al. · 2008 [cited by applicant]
US 7509171B2 · DiMauro · 2009 [cited by applicant]
US 7640062B2 · Shalev · 2009 [cited by applicant]
US 7831306B2 · Finch et al. · 2010 [cited by applicant]
US 7860569B2 · Solberg et al. · 2010 [cited by applicant]
US 8060207B2 · Wallace et al. · 2011 [cited by applicant]
US 8190248B2 · Besio et al. · 2012 [cited by applicant]
US 8457761B2 · Wariar · 2013 [cited by applicant]
US 8577469B2 · Gross · 2013 [cited by applicant]
US 8676348B2 · Gross · 2014 [cited by applicant]
US 9616221B2 · Gross · 2017 [cited by applicant]
US 9724513B2 · Lane et al. · 2017 [cited by applicant]
US 10398884B2 · Lad et al. · 2019 [cited by applicant]
US 20020151948A1 · King et al. · 2002 [cited by applicant]
US 20020183683A1 · Lerner · 2002 [cited by applicant]
US 20030130707A1 · Gan et al. · 2003 [cited by applicant]
US 20030158589A1 · Katsnelson · 2003 [cited by applicant]
US 20030216792A1 · Levin et al. · 2003 [cited by applicant]
US 20030225331A1 · Diederich et al. · 2003 [cited by applicant]
US 20040002746A1 · Ryan et al. · 2004 [cited by applicant]
US 20040019381A1 · Pflueger · 2004 [cited by applicant]
US 20040049180A1 · Sharps et al. · 2004 [cited by applicant]
US 20040116977A1 · Finch et al. · 2004 [cited by applicant]
US 20040210209A1 · Yeung et al. · 2004 [cited by applicant]
US 20050010205A1 · Hovda et al. · 2005 [cited by applicant]
US 20050021104A1 · DiLorenzo · 2005 [cited by applicant]
US 20050119650A1 · Sanders et al. · 2005 [cited by applicant]
US 20050137646A1 · Wallace et al. · 2005 [cited by applicant]
US 20050137647A1 · Wallace et al. · 2005 [cited by applicant]
US 20050159790A1 · Shalev · 2005 [cited by applicant]
US 20050187589A1 · Wallace et al. · 2005 [cited by applicant]
US 20050203599A1 · Garabedian et al. · 2005 [cited by applicant]
US 20050203600A1 · Wallace et al. · 2005 [cited by applicant]
US 20050203602A1 · Wallace et al. · 2005 [cited by applicant]
US 20050222647A1 · Wahlstrand et al. · 2005 [cited by applicant]
US 20050277996A1 · Podhajsky et al. · 2005 [cited by applicant]
US 20060030895A1 · Simon et al. · 2006 [cited by applicant]
US 20060106430A1 · Fowler et al. · 2006 [cited by applicant]
US 20060224223A1 · Podhajsky et al. · 2006 [cited by applicant]
US 20060293723A1 · Whitehurst et al. · 2006 [cited by applicant]
US 20070000784A1 · Paul et al. · 2007 [cited by applicant]
US 20070073402A1 · Vresilovic et al. · 2007 [cited by applicant]
US 20070162086A1 · Dilorenzo · 2007 [cited by applicant]
US 20070213700A1 · Davison et al. · 2007 [cited by applicant]
US 20070233202A1 · Wallace et al. · 2007 [cited by applicant]
US 20070255338A1 · Wahlstrand · 2007 [cited by applicant]
US 20080009927A1 · Vilims · 2008 [cited by applicant]
US 20080119907A1 · Stahmann · 2008 [cited by applicant]
US 20080260542A1 · Nishikawa et al. · 2008 [cited by applicant]
US 20090112278A1 · Wingeier et al. · 2009 [cited by applicant]
US 20090125080A1 · Montgomery · 2009 [cited by applicant]
US 20090126813A1 · Yanagisawa et al. · 2009 [cited by applicant]
US 20090131850A1 · Geiger · 2009 [cited by applicant]
US 20090312816A1 · Gross · 2009 [cited by examiner]
US 20100217369A1 · Gross · 2010 [cited by applicant]
US 20100324441A1 · Hargrove et al. · 2010 [cited by applicant]
US 20110046540A1 · Alterman et al. · 2011 [cited by applicant]
US 20110054518A1 · Carbunaru et al. · 2011 [cited by applicant]
US 20110160638A1 · Mauge et al. · 2011 [cited by applicant]
US 20110160797A1 · Makous et al. · 2011 [cited by applicant]
US 20120053659A1 · Molnar et al. · 2012 [cited by applicant]
US 20120203307A1 · Schroeppel et al. · 2012 [cited by applicant]
US 20130066392A1 · Simon et al. · 2013 [cited by applicant]
US 20130102952A1 · Gross · 2013 [cited by applicant]
US 20130166006A1 · Williams · 2013 [cited by applicant]
US 20130289385A1 · Lozano et al. · 2013 [cited by applicant]
US 20140058189A1 · Stubbeman · 2014 [cited by applicant]
US 20140088672A1 · Bedenbaugh · 2014 [cited by applicant]
US 20140207224A1 · Simon · 2014 [cited by applicant]
US 20140257168A1 · Gill · 2014 [cited by applicant]
US 20140324128A1 · Gross · 2014 [cited by applicant]
US 20150011927A1 · Hua · 2015 [cited by applicant]
US 20150119898A1 · Desalles et al. · 2015 [cited by applicant]
US 20160331970A1 · Lozano · 2016 [cited by applicant]
US 20170007823A1 · Gross · 2017 [cited by applicant]
US 20170120053A1 · Fostick et al. · 2017 [cited by applicant]
US 20170274207A1 · Gross · 2017 [cited by applicant]
JP 2004321242 · 2004 [cited by applicant]
JP 2007501067 · 2007 [cited by applicant]
WO 9405369 · 1994 [cited by applicant]
WO 0152931 · 2001 [cited by applicant]
WO 0185027 · 2001 [cited by applicant]
WO 2001085094 · 2001 [cited by applicant]
WO 2005011805 · 2005 [cited by applicant]
WO 2006090397 · 2006 [cited by applicant]
WO 2008007369 · 2008 [cited by applicant]
WO 2017072769 · 2017 [cited by applicant]
U.S. Appl. No. 13/872,794, filed Apr. 29, 2013, published as 2014/0324128, issued as U.S. Pat. No. 9,731,122. [cited by applicant]
U.S. Appl. No. 15/618,325, filed Jun. 9, 2017, published as 2017/0274207. [cited by applicant]
Karran September E et201 al., 1 “The Amyloid cascade hypothesis for AD,” Nature Reviews Drug Discovery, vol. 10; 698-712. [cited by applicant]
De La Torre JC, “Vascular Basis of Alzheimer's Pathogensis,” Ann NY Acad Sci. 977:196-215 (Nov. 2002). [cited by applicant]
Weller RO et al., “Perivascular Drainage of Amyloid-b Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease,” Brain Pathology 18 (Apr. 2008) 253-266. [cited by applicant]
Brief PubMed search for metal ions in Alzheimers. [cited by applicant]
An Office Action dated Sep. 27, 2016, which issued during the prosecution of U.S. Appl. No. 14/926,705. [cited by applicant]
An International Search Report and a Written Opinion both dated Aug. 7, 2008, which issued during the prosecution of Applicant's PCT/IL2007/000865. [cited by applicant]
An Office Action dated Mar. 29, 2013, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Oct. 31, 2011, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Oct. 1, 2012, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
Notice of Allowance dated Jul. 24, 2013, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Apr. 11, 2013, which issued during the prosecution of U.S. Appl. No. 13/663,757. [cited by applicant]
Notice of Allowance dated Oct. 28, 2013, which issued during the prosecution of U.S. Appl. No. 13/663,757. [cited by applicant]
Elixmann IM et al., “In-vitro evaluation of a drainage catheter with integrated bioimpedance electrodes to determine ventricular size,” Biomed Tech 2013; 58 (Suppl. 1) Sep. 2013 (2 pages total). [cited by applicant]
An Office Action dated Aug. 31, 2015, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Applicant Initiated Interview Summary dated Dec. 14, 2015, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Office Action dated Feb. 3, 2016, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
Notice of Allowance dated Dec. 9, 2016, which issued during the prosecution of U.S. Appl. No. 14/794,739. [cited by applicant]
An Applicant Initiated Summary dated Feb. 25, 2016, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Office Action dated Jun. 15, 2016, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An International Search Report and a Written Opinion both dated Oct. 20, 2016, which issued during the prosecution of Applicant's PCT/IL2016/050728. [cited by applicant]
An Office Action dated Sep. 21, 2016, which issued during the prosecution of U.S. Appl. No. 14/794,739. [cited by applicant]
An International Search Report and a Written Opinion both dated Jan. 26, 2017, which issued during the prosecution of Applicant's PCT/IL2016/051161. [cited by applicant]
Notice of Allowance dated Jul. 14, 2017, which issued during the prosecution of U.S. Appl. No. 13/872,794. [cited by applicant]
An Office Action dated May 26, 2017, which issued during the prosecution of U.S. Appl. No. 15/453,290. [cited by applicant]
An International Preliminary Report on Patentability dated Apr. 7, 2009, which issued during the prosecution of Applicant's PCT/IL2007/000865. [cited by applicant]
Loutzenhiser, “Membrane Potential measurements in renal afferent and efferent arterioles: actions of Angiotensin II”, AJP-Renal Physiol Aug. 1, 1997 vol. 273 No. 2 F307-F314. [cited by applicant]
U.S. Appl. No. 60/830,717, filed Jul. 12, 2006. [cited by applicant]
Dao-Sheng Liu et al., “Activation of Na+ and K+ Pumping Modes of (Na,K)-ATPase by an Oscillation Electric Field,” The Journal of Biological Chemistry, vol. 265. No. 13, May 5, 1990. (pp. 7260-7267). [cited by applicant]
Robert F. Service.. “Electric fields deliver druas into tumors.” http://news.sciencemaa.ora. Feb. 4, 2015. (5 Pages Total). [cited by applicant]
Vernengo J, “Injectable Bioadhesive Hydrogels for Nucleus Pulposus Replacement and Repair of the Damaged Intervertebral Disc: A Thesis,” Drexel University (Jan. 2007). [cited by applicant]
Urban JPG et al., “The nucleus of the intervertebral disc from development to degeneration,” American Zoologist 40(1): 53-61 (2000). [cited by applicant]
Cheung KMC et al., “Intervertebral disc regeneration by use of autologous mesenchymal stem cells, an experimental model in rabbits,” Abstract from the SRS 2004 Annual Meeting. [cited by applicant]
Freemont TJ et al., “Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies,” Expert Reviews in Molecular Biology, Mar. 29, 2001 (Cambridge Uni… [cited by applicant]
An Office Action dated Sep. 12, 2011, which issued during the prosecution of U.S. Appl. No. 12/373,306. [cited by applicant]
An Office Action dated Jul. 24, 2017, which issued during the prosecution of U.S. Appl. No. 14/982,187. [cited by applicant]
An International Search Report and a Written Opinion both dated Mar. 10, 2017, which issued during the prosecution of Applicant's PCT/IL2016/051363. [cited by applicant]
An Office Action dated Mar. 25, 2019, which issued during the prosecution of U.S. Appl. No. 15/742,245. [cited by applicant]
An Office Action together with the English translation dated Aug. 19, 2020, which issued during the prosecution of Japanese Patent Application No. 2018-521586. [cited by applicant]
An Office Action dated Apr. 25, 2018, which issued during the prosecution of U.S. Appl. No. 15/637,330. [cited by applicant]
An Office Action dated Nov. 20, 2020, which issued during the prosecution of U.S. Appl. No. 16/353,407. [cited by applicant]
An Office Action dated Jan. 22, 2020, which issued during the prosecution of U.S. Appl. No. 15/771,551. [cited by applicant]
An Office Action dated Nov. 29, 2019, which issued during the prosecution of U.S. Appl. No. 15/969,411. [cited by applicant]
An International Search Report and a Written Opinion both dated May 23, 2019, which issued during the prosecution of Applicant's PCT/IL2019/050284. [cited by applicant]
An Office Action dated Jul. 29, 2019, which issued during the prosecution of U.S. Appl. No. 15/618,325. [cited by applicant]
An Office Action dated Mar. 6, 2020, which issued during the prosecution of U.S. Appl. No. 15/618,325. [cited by applicant]
Sawyer PN et al., “Measurement of streaming potentials of mammalian blood vessels, aorta and venacava, in vivo,” Biophysical journal vol. 6,5 (1966): 641-51. doi: 10.1016/50006-3495(66)86683-3. [cited by applicant]