IP Library › Granted Patent US 12,209,128
Granted Patent B2
US 12,209,128 · App. 17/243,372 · Granted Jan 28, 2025

Anti-PD-L1 antibodies

Inventors: Jamie Campbell (Cambridge, GB); Nikole Sandy (Cambridge, GB); Cassandra Van Krinks (Cambridge, GB); Stephen John Arkinstall (Cambridge, MA); Volker Germaschewski (Cambridge, GB); Ian Kirby (Cambridge, GB); Miha Kosmac (Cambridge, GB); Thomas Gallagher (Cambridge, GB); Cecilia Deantonio (Cambridge, GB); Stephen Douglas Gillies (Carlisle, MA)
Assignee: KYMAB LIMITED
C07K16/2827C07K14/55C07K16/28C07K16/2803C07K16/468C07K19/00A61K2039/505C07K2317/21C07K2317/31C07K2317/33C07K2317/524C07K2317/56C07K2317/565C07K2317/567C07K2317/71C07K2317/76C07K2317/92C07K2319/00C07K2319/02C07K2319/30C07K2319/74
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Quick Facts
Patent No.
US 12,209,128
App. No.
17/243,372
Granted
Jan 28, 2025
Kind
B2
Abstract

The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Claims (54)

1. An antibody or fragment thereof which specifically binds to hPD-L1, wherein the:

a) V H domain comprises the amino acid sequence of SEQ ID NO: 540 and the V L domain comprises the amino acid sequence of SEQ ID NO: 43;

b) V H domain comprises the amino acid sequence of SEQ ID NO: 541 and the V L domain comprises the amino acid sequence of SEQ ID NO: 43;

c) V H domain comprises the amino acid sequence of SEQ ID NO: 542 and the V L domain comprises the amino acid sequence of SEQ ID NO: 43;

d) V H domain comprises the amino acid sequence of SEQ ID NO: 33 and the V L domain comprises the amino acid sequence of SEQ ID NO: 544;

e) V H domain comprises the amino acid sequence of SEQ ID NO: 540 and the V L domain comprises the amino acid sequence of the V L domain of SEQ ID NO: 544;

f) V H domain comprises the amino acid sequence of SEQ ID NO: 541 and the V L domain comprises the amino acid sequence of SEQ ID NO: 544;

g) V H domain comprises the amino acid sequence of SEQ ID NO: 542 and the V L domain comprises the amino acid sequence of SEQ ID NO: 544;

h) V H domain comprises the amino acid sequence of SEQ ID NO: 33 and the V L domain comprises the amino acid sequence of SEQ ID NO: 545;

i) V H domain comprises the amino acid sequence of SEQ ID NO: 540 and the V L domain comprises the amino acid sequence of SEQ ID NO: 544;

j) V H domain comprises the amino acid sequence of SEQ ID NO: 541 and the V L domain comprises the amino acid sequence of SEQ ID NO: 544;

k) V H domain comprise the amino acid sequence of SEQ ID NO: 542 and the V L domain comprises the amino acid sequence of SEQ ID NO: 544;

l) V H domain comprises the amino acid sequence of SEQ ID NO: 33 and the V L domain comprises the amino acid sequence of SEQ ID NO: 543;

m) V H domain comprises the amino acid sequence of the V H domain of SEQ ID NO: 540 and the V L domain comprises the amino acid sequence of SEQ ID NO: 543;

n) V H domain comprises the amino acid sequence of SEQ ID NO: 541 and the V L domain comprises the amino acid sequence of SEQ ID NO: 543;

o) V H domain comprise the amino acid sequence of SEQ ID NO: 542 and the V L domain comprises the amino acid sequence of SEQ ID NO: 543.

2. The antibody or fragment thereof according to claim 1 , wherein the antibody or fragment thereof comprises a heavy chain and a light chain, and

a) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 47 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 45;

b) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 48 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 45;

c) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 49 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 45;

d) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 342 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 45;

e) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 35 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 50;

f) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 47 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 50;

g) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 48 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 50;

h) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 49 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 50;

i) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 342 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 50;

j) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 35 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 51;

k) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 47 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 51;

l) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 48 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 51;

m) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 49 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 51;

n) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 342 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 51;

o) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 35 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 298;

p) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 47 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 298;

q) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 48 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 298;

r) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 49 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 298;

s) the heavy chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 342 and the light chain amino acid sequence comprises the amino acid sequence of SEQ ID NO: 298.

3. A pharmaceutical composition comprising the antibody or fragment thereof of claim 1 and a pharmaceutically acceptable excipient, diluent or carrier.

4. A kit comprising the pharmaceutical composition of claim 3 , wherein the composition is for treating a hPD-L1-mediated condition or disease.

5. The pharmaceutical composition of claim 3 , further comprising a therapeutic agent independently selected from the group consisting of:

a) other immune checkpoint inhibitors;

b) immune stimulators;

c) chemokine receptor antagonists;

d) targeted kinase inhibitors;

e) angiogenesis inhibitors;

f) immune stimulating peptides or chemokines;

g) cytokines;

h) bispecific T-cell engagers (BiTEs) having at least one specificity against CD3;

i) other bi-specific molecules;

j) oncolytic viruses;

k) vaccination with tumour associated antigens;

l) cell-based therapies;

m) bi-specific NK cell engagers having a specificity against an activating MK receptor; and

n) adoptive transfer of tumour specific T-cells or LAK cells.

6. The antibody or fragment thereof of claim 1 , wherein the antibody or fragment comprises a human constant region comprising the amino acid sequence of SEQ ID NO: 199 or SEQ ID NO: 205.

Assignments (1)
SECURITY INTEREST Recorded Feb 17, 2026
From: IMMUNOBRAIN CHECKPOINT, INC.
To: RVIBC LENDER LLC
Reel/Frame 074878/0973 →
Priority Claims (8)
GB 1613683 · Aug 9, 2016 · national
GB 1615224 · Sep 7, 2016 · national
GB 1615335 · Sep 9, 2016 · national
GB 1620414 · Dec 1, 2016 · national
GB 1621782 · Dec 20, 2016 · national
GB 1702338 · Feb 13, 2017 · national
GB 1702339 · Feb 13, 2017 · national
GB 1703071 · Feb 24, 2017 · national
Continuity (3)
Continuation 16311440
Provisional Application 62352291 · Jun 20, 2016
Related Publication 20210380699A1 · Dec 9, 2021
References Cited (400)
US 4663281A · Gillies et al. · 1987 [cited by applicant]
US 4741900A · Alvarez et al. · 1988 [cited by applicant]
US 4816397A · Boss et al. · 1989 [cited by applicant]
US 5219996A · Bodmer et al. · 1993 [cited by applicant]
US 5223409A · Ladner et al. · 1993 [cited by applicant]
US 5314995A · Fell, Jr. et al. · 1994 [cited by applicant]
US 5403484A · Ladner et al. · 1995 [cited by applicant]
US 5427908A · Dower et al. · 1995 [cited by applicant]
US 5516637A · Huang et al. · 1996 [cited by applicant]
US 5545806A · Lonberg et al. · 1996 [cited by applicant]
US 5545807A · Surani et al. · 1996 [cited by applicant]
US 5569825A · Lonberg et al. · 1996 [cited by applicant]
US 5571698A · Ladner et al. · 1996 [cited by applicant]
US 5580717A · Dower et al. · 1996 [cited by applicant]
US 5585089A · Queen et al. · 1996 [cited by applicant]
US 5625126A · Lonberg et al. · 1997 [cited by applicant]
US 5633425A · Lonberg et al. · 1997 [cited by applicant]
US 5645835A · Fell, Jr. et al. · 1997 [cited by applicant]
US 5658727A · Barbas et al. · 1997 [cited by applicant]
US 5661016A · Lonberg et al. · 1997 [cited by applicant]
US 5677425A · Bodmer et al. · 1997 [cited by applicant]
US 5698426A · Huse · 1997 [cited by applicant]
US 5712380A · Kendall et al. · 1998 [cited by applicant]
US 5733743A · Johnson et al. · 1998 [cited by applicant]
US 5750753A · Kimae et al. · 1998 [cited by applicant]
US 5766886A · Studnicka et al. · 1998 [cited by applicant]
US 5770429A · Lonberg et al. · 1998 [cited by applicant]
US 5780225A · Wigler et al. · 1998 [cited by applicant]
US 5821047A · Garrard et al. · 1998 [cited by applicant]
US 5869046A · Presta et al. · 1999 [cited by applicant]
US 5869619A · Studnicka · 1999 [cited by applicant]
US 5969108A · McCafferty et al. · 1999 [cited by applicant]
US 6011003A · Charnock-Jones et al. · 2000 [cited by applicant]
US 6028176A · Greve et al. · 2000 [cited by applicant]
US 6100071A · Davis-Smyth et al. · 2000 [cited by applicant]
US 6121022A · Presta et al. · 2000 [cited by applicant]
US 6331415B1 · Cabilly et al. · 2001 [cited by applicant]
US 6407088B1 · Dong et al. · 2002 [cited by applicant]
US 6528055B2 · Godfrey et al. · 2003 [cited by applicant]
US 6528623B2 · Godfrey et al. · 2003 [cited by applicant]
US 6548507B1 · Bountra et al. · 2003 [cited by applicant]
US 6599906B1 · Ku et al. · 2003 [cited by applicant]
US 6803039B2 · Tsuji et al. · 2004 [cited by applicant]
US 6875432B2 · Liu et al. · 2005 [cited by applicant]
US 6897294B2 · Davis-Smyth et al. · 2005 [cited by applicant]
US 7029895B2 · Glucksmann et al. · 2006 [cited by applicant]
US 7030225B1 · Tamatani et al. · 2006 [cited by applicant]
US 7045615B2 · Tamatani et al. · 2006 [cited by applicant]
US 7056509B2 · Thorpe et al. · 2006 [cited by applicant]
US 7098184B2 · Godfrey et al. · 2006 [cited by applicant]
US 7125551B2 · Kroczek · 2006 [cited by applicant]
US 7129338B1 · Ota et al. · 2006 [cited by applicant]
US 7132099B2 · Kroczek · 2006 [cited by applicant]
US 7166283B2 · Tsuji et al. · 2007 [cited by applicant]
US 7196175B2 · Tamatani et al. · 2007 [cited by applicant]
US 7226909B2 · Tamatani et al. · 2007 [cited by applicant]
US 7259247B1 · Kroczek · 2007 [cited by applicant]
US 7261893B2 · Veldman et al. · 2007 [cited by applicant]
US 7279560B2 · Tamatani et al. · 2007 [cited by applicant]
US 7291331B1 · Croft et al. · 2007 [cited by applicant]
US 7300754B2 · Abi Fadel et al. · 2007 [cited by applicant]
US 7304033B2 · Larsen · 2007 [cited by applicant]
US 7306800B2 · Kroczek · 2007 [cited by applicant]
US 7368531B2 · Rosen et al. · 2008 [cited by applicant]
US 7411051B2 · Rosen et al. · 2008 [cited by applicant]
US 7438905B2 · Suzuki et al. · 2008 [cited by applicant]
US 7456187B2 · Ford et al. · 2008 [cited by applicant]
US 7456264B2 · Keler et al. · 2008 [cited by applicant]
US 7465445B2 · Tezuka et al. · 2008 [cited by applicant]
US 7482147B2 · Glucksmann et al. · 2009 [cited by applicant]
US 7501496B1 · Endl et al. · 2009 [cited by applicant]
US 7521541B2 · Eigenbrot et al. · 2009 [cited by applicant]
US 7572618B2 · Mintier et al. · 2009 [cited by applicant]
US 7582288B2 · Gillies et al. · 2009 [cited by applicant]
US 7704500B2 · Papadopoulos et al. · 2010 [cited by applicant]
US 7722872B2 · Kroczek · 2010 [cited by applicant]
US 7776577B2 · Kapeller-Libermann et al. · 2010 [cited by applicant]
US 7794710B2 · Chen et al. · 2010 [cited by applicant]
US 7812133B2 · Martin · 2010 [cited by applicant]
US 7868141B2 · Endl et al. · 2011 [cited by applicant]
US 7892540B2 · Chen · 2011 [cited by applicant]
US 7932358B2 · Tamatani et al. · 2011 [cited by applicant]
US 7943743B2 · Korman et al. · 2011 [cited by applicant]
US 7968689B2 · Rosen et al. · 2011 [cited by applicant]
US 7972813B2 · McCormack et al. · 2011 [cited by applicant]
US 7988965B2 · Tsuji et al. · 2011 [cited by applicant]
US 7998478B2 · Tezuka et al. · 2011 [cited by applicant]
US 8008449B2 · Korman et al. · 2011 [cited by applicant]
US 8030457B2 · Jackson et al. · 2011 [cited by applicant]
US 8062640B2 · Sleeman et al. · 2011 [cited by applicant]
US 8080243B2 · Liang et al. · 2011 [cited by applicant]
US 8101175B1 · Croft et al. · 2012 [cited by applicant]
US 8168179B2 · Honjo · 2012 [cited by applicant]
US 8168762B2 · Jackson et al. · 2012 [cited by applicant]
US 8188233B2 · Condra et al. · 2012 [cited by applicant]
US 8188234B2 · Condra et al. · 2012 [cited by applicant]
US 8318905B2 · Kroczek · 2012 [cited by applicant]
US 8344114B2 · Sparrow et al. · 2013 [cited by applicant]
US 8357371B2 · Sleeman et al. · 2013 [cited by applicant]
US 8389690B2 · Tamatani et al. · 2013 [cited by applicant]
US 8399646B2 · Liang et al. · 2013 [cited by applicant]
US 8420098B2 · Camphausen et al. · 2013 [cited by applicant]
US 8426363B2 · Liang et al. · 2013 [cited by applicant]
US 8486647B2 · Haber et al. · 2013 [cited by applicant]
US 8501184B2 · Sleeman et al. · 2013 [cited by applicant]
US 8530414B2 · Davies et al. · 2013 [cited by applicant]
US 8551477B1 · Croft et al. · 2013 [cited by applicant]
US 8563698B2 · Jackson et al. · 2013 [cited by applicant]
US 8598320B2 · Hedrick · 2013 [cited by applicant]
US 8840889B2 · Chen · 2014 [cited by applicant]
US 8916155B2 · Kroczek · 2014 [cited by applicant]
US 8956615B1 · Croft et al. · 2015 [cited by applicant]
US 8962807B2 · Verdonck et al. · 2015 [cited by applicant]
US 9102725B2 · Korman · 2015 [cited by applicant]
US 9139653B1 · Campbell et al. · 2015 [cited by applicant]
US 9234043B1 · Campbell · 2016 [cited by applicant]
US 9376493B2 · Faget et al. · 2016 [cited by applicant]
US 9428570B2 · Lawson · 2016 [cited by applicant]
US 9434785B1 · Bland-Ward et al. · 2016 [cited by applicant]
US 9512229B2 · Bland-Ward · 2016 [cited by applicant]
US 9567399B1 · Campbell · 2017 [cited by applicant]
US 9587030B2 · Campbell · 2017 [cited by applicant]
US 9617338B1 · Campbell · 2017 [cited by applicant]
US 9868789B2 · Bland-Ward · 2018 [cited by applicant]
US 9868790B2 · Bland-Ward · 2018 [cited by applicant]
US 9957323B2 · Sainson · 2018 [cited by examiner]
US 10118963B2 · Zhou · 2018 [cited by applicant]
US 10214586B2 · Ludwig et al. · 2019 [cited by applicant]
US 10604576B2 · Campbell · 2020 [cited by applicant]
US 10654935B2 · Campbell et al. · 2020 [cited by applicant]
US 10669342B2 · Campbell et al. · 2020 [cited by applicant]
US 11965026B2 · Cambell · 2024 [cited by examiner]
US 20020064555A1 · Chiang et al. · 2002 [cited by applicant]
US 20020045571A1 · Liu et al. · 2002 [cited by applicant]
US 20020081679A1 · Chiang et al. · 2002 [cited by applicant]
US 20020082259A1 · Ono et al. · 2002 [cited by applicant]
US 20020114814A1 · Gray · 2002 [cited by applicant]
US 20020150576A1 · LaRosa et al. · 2002 [cited by applicant]
US 20020156242A1 · Tamatani et al. · 2002 [cited by applicant]
US 20030119038A1 · Bingham et al. · 2003 [cited by applicant]
US 20030124149A1 · Shalaby et al. · 2003 [cited by applicant]
US 20030158402A1 · Hall · 2003 [cited by applicant]
US 20040009553A1 · Glucksmann et al. · 2004 [cited by applicant]
US 20040023243A1 · Henry et al. · 2004 [cited by applicant]
US 20040038242A1 · Edmonds et al. · 2004 [cited by applicant]
US 20040110226A1 · Lazar · 2004 [cited by applicant]
US 20040191265A1 · Schenerman et al. · 2004 [cited by applicant]
US 20040248177A1 · Abi Fadel et al. · 2004 [cited by applicant]
US 20040265309A1 · Kandel et al. · 2004 [cited by applicant]
US 20050085433A1 · Breidenstein et al. · 2005 [cited by applicant]
US 20050101529A1 · Yue et al. · 2005 [cited by applicant]
US 20050118625A1 · Mounts · 2005 [cited by applicant]
US 20050147612A1 · Yayon et al. · 2005 [cited by applicant]
US 20050175610A1 · Wiegand et al. · 2005 [cited by applicant]
US 20050197285A1 · Rosen et al. · 2005 [cited by applicant]
US 20050260203A1 · Wiegand et al. · 2005 [cited by applicant]
US 20050271656A1 · Huang · 2005 [cited by applicant]
US 20050281822A1 · Cedarbaum et al. · 2005 [cited by applicant]
US 20050281831A1 · Davis-Smyth et al. · 2005 [cited by applicant]
US 20060002929A1 · Khare et al. · 2006 [cited by applicant]
US 20060116508A1 · Glucksmann et al. · 2006 [cited by applicant]
US 20060147945A1 · Edmonds et al. · 2006 [cited by applicant]
US 20060210566A1 · Holash et al. · 2006 [cited by applicant]
US 20060223088A1 · Rosen et al. · 2006 [cited by applicant]
US 20060223090A1 · Rosen et al. · 2006 [cited by applicant]
US 20060246071A1 · Green et al. · 2006 [cited by applicant]
US 20060246483A1 · Rosen et al. · 2006 [cited by applicant]
US 20070015696A1 · Rosen et al. · 2007 [cited by applicant]
US 20070037206A1 · Rosen et al. · 2007 [cited by applicant]
US 20070037748A1 · Stahl et al. · 2007 [cited by applicant]
US 20070041963A1 · Rosen · 2007 [cited by applicant]
US 20070041972A1 · Rother et al. · 2007 [cited by applicant]
US 20070055056A1 · Rosen et al. · 2007 [cited by applicant]
US 20070082345A1 · Ota et al. · 2007 [cited by applicant]
US 20070122378A1 · Freeman et al. · 2007 [cited by applicant]
US 20070224663A1 · Rosen et al. · 2007 [cited by applicant]
US 20070292440A1 · Kenyon · 2007 [cited by applicant]
US 20080008697A1 · Mintier et al. · 2008 [cited by applicant]
US 20080069795A1 · Rabb · 2008 [cited by applicant]
US 20080103090A1 · Rosen et al. · 2008 [cited by applicant]
US 20080113930A1 · Tan et al. · 2008 [cited by applicant]
US 20080279862A1 · Khare · 2008 [cited by applicant]
US 20090053230A1 · Martin · 2009 [cited by applicant]
US 20090055944A1 · Korman et al. · 2009 [cited by applicant]
US 20090142352A1 · Jackson et al. · 2009 [cited by applicant]
US 20090232795A1 · Condra et al. · 2009 [cited by applicant]
US 20090246192A1 · Condra et al. · 2009 [cited by applicant]
US 20090252749A1 · Leister · 2009 [cited by applicant]
US 20090269350A1 · Glucksmann et al. · 2009 [cited by applicant]
US 20090326202A1 · Jackson et al. · 2009 [cited by applicant]
US 20100040610A1 · Sitlani et al. · 2010 [cited by applicant]
US 20100040611A1 · Sparrow et al. · 2010 [cited by applicant]
US 20100041102A1 · Sitlani et al. · 2010 [cited by applicant]
US 20100068194A1 · Kim · 2010 [cited by applicant]
US 20100068199A1 · Liang et al. · 2010 [cited by applicant]
US 20100098712A1 · Adler et al. · 2010 [cited by applicant]
US 20100136028A1 · Sparrow et al. · 2010 [cited by applicant]
US 20100150937A1 · Sparrow et al. · 2010 [cited by applicant]
US 20100166740A1 · Endl et al. · 2010 [cited by applicant]
US 20100166768A1 · Sleeman et al. · 2010 [cited by applicant]
US 20100183591A1 · Baron · 2010 [cited by applicant]
US 20100183612A1 · Peach · 2010 [cited by applicant]
US 20100203056A1 · Irving et al. · 2010 [cited by applicant]
US 20100233177A1 · Yowe et al. · 2010 [cited by applicant]
US 20100291099A1 · Glucksmann et al. · 2010 [cited by applicant]
US 20100323359A1 · MacDonald et al. · 2010 [cited by applicant]
US 20110027287A1 · Jackson et al. · 2011 [cited by applicant]
US 20110033451A1 · Carreno · 2011 [cited by applicant]
US 20110033465A1 · Hedrick · 2011 [cited by applicant]
US 20110065902A1 · Sleeman et al. · 2011 [cited by applicant]
US 20110070239A1 · Endl et al. · 2011 [cited by applicant]
US 20110091481A1 · Burnette · 2011 [cited by applicant]
US 20110105726A1 · Rosen · 2011 [cited by applicant]
US 20110117011A1 · Jackson et al. · 2011 [cited by applicant]
US 20110135662A1 · Finney et al. · 2011 [cited by applicant]
US 20110142849A1 · Rue · 2011 [cited by applicant]
US 20110229489A1 · Pons et al. · 2011 [cited by applicant]
US 20110230392A1 · Chiang et al. · 2011 [cited by applicant]
US 20110256148A1 · Sleeman et al. · 2011 [cited by applicant]
US 20110307966A1 · MacDonald et al. · 2011 [cited by applicant]
US 20120014951A1 · Liang et al. · 2012 [cited by applicant]
US 20120015435A1 · Liang et al. · 2012 [cited by applicant]
US 20120020975A1 · Jackson et al. · 2012 [cited by applicant]
US 20120020976A1 · Jackson et al. · 2012 [cited by applicant]
US 20120027751A1 · Rennert · 2012 [cited by applicant]
US 20120027765A1 · Jackson et al. · 2012 [cited by applicant]
US 20120058906A1 · Smider · 2012 [cited by applicant]
US 20120064621A1 · Papadopoulos et al. · 2012 [cited by applicant]
US 20120076799A1 · Sparrow et al. · 2012 [cited by applicant]
US 20120077964A1 · Sparrow et al. · 2012 [cited by applicant]
US 20120082679A1 · Sparrow et al. · 2012 [cited by applicant]
US 20120082680A1 · Sitlani et al. · 2012 [cited by applicant]
US 20120185956A1 · Gingras et al. · 2012 [cited by applicant]
US 20120195910A1 · Wu et al. · 2012 [cited by applicant]
US 20120208208A1 · Ni et al. · 2012 [cited by applicant]
US 20120208209A1 · Ichetovkin et al. · 2012 [cited by applicant]
US 20120213794A1 · Luo et al. · 2012 [cited by applicant]
US 20120213797A1 · Jackson et al. · 2012 [cited by applicant]
US 20120219558A1 · Ni et al. · 2012 [cited by applicant]
US 20120231005A1 · Luo et al. · 2012 [cited by applicant]
US 20120251544A1 · Jackson et al. · 2012 [cited by applicant]
US 20120269723A1 · Brinkmann et al. · 2012 [cited by applicant]
US 20120301461A1 · Condra et al. · 2012 [cited by applicant]
US 20120321879A1 · Teutsch et al. · 2012 [cited by applicant]
US 20120328616A1 · Li et al. · 2012 [cited by applicant]
US 20130018175A1 · Verdonck · 2013 [cited by applicant]
US 20130052201A1 · Jackson et al. · 2013 [cited by applicant]
US 20130058944A1 · Jackson et al. · 2013 [cited by applicant]
US 20130064825A1 · Chan et al. · 2013 [cited by applicant]
US 20130064834A1 · Sleeman et al. · 2013 [cited by applicant]
US 20130071379A1 · Condra et al. · 2013 [cited by applicant]
US 20130071405A1 · Davies et al. · 2013 [cited by applicant]
US 20130072665A1 · Jackson et al. · 2013 [cited by applicant]
US 20130079501A1 · Jackson et al. · 2013 [cited by applicant]
US 20130079502A1 · Jackson et al. · 2013 [cited by applicant]
US 20130085265A1 · Jackson et al. · 2013 [cited by applicant]
US 20130085266A1 · Sleeman et al. · 2013 [cited by applicant]
US 20130095108A1 · Nadler et al. · 2013 [cited by applicant]
US 20130095109A1 · Nadler · 2013 [cited by applicant]
US 20130115171A1 · McDonough et al. · 2013 [cited by applicant]
US 20130115223A1 · Sparrow et al. · 2013 [cited by applicant]
US 20130142783A1 · Coyle · 2013 [cited by applicant]
US 20130183315A1 · Attinger · 2013 [cited by applicant]
US 20130189278A1 · Sitlani · 2013 [cited by applicant]
US 20130245235A1 · Jackson et al. · 2013 [cited by applicant]
US 20130273069A1 · Liang et al. · 2013 [cited by applicant]
US 20130310324A1 · Flinspach et al. · 2013 [cited by applicant]
US 20140044703A1 · Kato et al. · 2014 [cited by applicant]
US 20140086932A1 · Traber et al. · 2014 [cited by applicant]
US 20140161794A1 · Lugovsky · 2014 [cited by applicant]
US 20140093497A1 · Reimann · 2014 [cited by applicant]
US 20140165219A1 · Leppert et al. · 2014 [cited by applicant]
US 20140170157A1 · Agarwal et al. · 2014 [cited by applicant]
US 20140286897A1 · Podack · 2014 [cited by applicant]
US 20140322132A1 · Vitalis et al. · 2014 [cited by applicant]
US 20150203580A1 · Papadopoulos et al. · 2015 [cited by applicant]
US 20150239978A1 · Marodon et al. · 2015 [cited by applicant]
US 20150307620A1 · Vella et al. · 2015 [cited by applicant]
US 20160000909A1 · Eisenbach-Schwartz et al. · 2016 [cited by applicant]
US 20160002336A1 · Chen · 2016 [cited by applicant]
US 20160024211A1 · Chen · 2016 [cited by applicant]
US 20160145344A1 · Akbari · 2016 [cited by applicant]
US 20160215059A1 · Liu et al. · 2016 [cited by applicant]
US 20160264666A1 · Faget et al. · 2016 [cited by applicant]
US 20160264675A1 · Bland-Ward et al. · 2016 [cited by applicant]
US 20160304610A1 · Sazinsky et al. · 2016 [cited by applicant]
US 20160361364A1 · Corbascio · 2016 [cited by applicant]
US 20170037137A1 · Bland-Ward · 2017 [cited by applicant]
US 20170362321A1 · Campbell et al. · 2017 [cited by applicant]
US 20180305464A1 · Li et al. · 2018 [cited by applicant]
US 20190077867A1 · Zhu et al. · 2019 [cited by applicant]
US 20190276547A1 · Campbell · 2019 [cited by applicant]
US 20190330351A1 · Campbell et al. · 2019 [cited by applicant]
US 20200231692A1 · Hu et al. · 2020 [cited by applicant]
US 20210380699A1 · Campbell et al. · 2021 [cited by applicant]
CN 101023102 · 2007 [cited by applicant]
CN 101248089 · 2008 [cited by applicant]
CN 101374865 · 2009 [cited by applicant]
CN 103221427 · 2013 [cited by applicant]
EP 0438474 · 1996 [cited by applicant]
EP 0463151 · 1996 [cited by applicant]
EP 0546073 · 1997 [cited by applicant]
EP 0984023 · 2000 [cited by applicant]
EP 0996622 · 2000 [cited by applicant]
EP 1067182 · 2001 [cited by applicant]
EP 1125585 · 2001 [cited by applicant]
EP 1158004 · 2001 [cited by applicant]
EP 1374901 · 2004 [cited by applicant]
EP 1502920 · 2005 [cited by applicant]
EP 1514933 · 2005 [cited by applicant]
EP 1286668 · 2005 [cited by applicant]
EP 1618212 · 2007 [cited by applicant]
EP 2481758 · 2012 [cited by applicant]
EP 1740617 · 2013 [cited by applicant]
EP 2650016 · 2013 [cited by applicant]
EP 2691419 · 2016 [cited by applicant]
EP 3369745 · 2018 [cited by applicant]
EP 2812022 · 2019 [cited by applicant]
EP 3495391 · 2019 [cited by applicant]
JP 2005130764 · 2005 [cited by applicant]
JP 2009518005 · 2007 [cited by applicant]
JP 2008512995 · 2008 [cited by applicant]
JP 2016555520 · 2017 [cited by applicant]
RU 2540490 · 2015 [cited by applicant]
WO WO1985004880 · 1985 [cited by applicant]
WO WO1990002809 · 1990 [cited by applicant]
WO WO1991004329 · 1991 [cited by applicant]
WO WO1991009967 · 1991 [cited by applicant]
WO WO1991010737 · 1991 [cited by applicant]
WO WO1991013166 · 1991 [cited by applicant]
WO WO1992001047 · 1992 [cited by applicant]
WO WO1992002551 · 1992 [cited by applicant]
WO WO1992008495 · 1992 [cited by applicant]
WO WO1992008801 · 1992 [cited by applicant]
WO WO1992018619 · 1992 [cited by applicant]
WO WO1992022583 · 1992 [cited by applicant]
WO WO1993011236 · 1993 [cited by applicant]
WO WO1993012227 · 1993 [cited by applicant]
WO WO1993020849 · 1993 [cited by applicant]
WO WO1995015982 · 1995 [cited by applicant]
WO WO1995020401 · 1995 [cited by applicant]
WO WO1995021915 · 1995 [cited by applicant]
WO WO1996008570 · 1996 [cited by applicant]
WO WO1997044453 · 1997 [cited by applicant]
WO WO1997049805 · 1997 [cited by applicant]
WO WO1998003821 · 1998 [cited by applicant]
WO WO1998013071 · 1998 [cited by applicant]
WO WO1998020734 · 1998 [cited by applicant]
WO WO1998024893 · 1998 [cited by applicant]
WO WO1998025971 · 1998 [cited by applicant]
WO WO1999003859 · 1999 [cited by applicant]
WO WO1999003996 · 1999 [cited by applicant]
WO WO1999015553 · 1999 [cited by applicant]
WO WO1999029732 · 1999 [cited by applicant]
WO WO1999043713 · 1999 [cited by applicant]
WO WO1999052562 · 1999 [cited by applicant]
WO WO1999053958 · 1999 [cited by applicant]
WO WO1999060128 · 1999 [cited by applicant]
WO WO2000011033 · 2000 [cited by applicant]
WO WO2000040615 · 2000 [cited by applicant]
WO WO2000047228 · 2000 [cited by applicant]
WO WO2000076310 · 2000 [cited by applicant]
WO WO2001007081 · 2001 [cited by applicant]
WO WO2001010912 · 2001 [cited by applicant]
WO WO2001014424 · 2001 [cited by applicant]
WO WO2001031007 · 2001 [cited by applicant]
WO WO2001057081 · 2001 [cited by applicant]
WO WO2001058957 · 2001 [cited by applicant]
WO WO2001087981 · 2001 [cited by applicant]
WO WO2001098468 · 2001 [cited by applicant]
WO WO2002000243 · 2002 [cited by applicant]
WO WO2002002143 · 2002 [cited by applicant]
WO WO2002014358 · 2002 [cited by applicant]
WO WO2002046383 · 2002 [cited by applicant]
WO WO2002057435 · 2002 [cited by applicant]
WO WO2002066514 · 2002 [cited by applicant]
WO WO2002072605 · 2002 [cited by applicant]
WO WO2002079232 · 2002 [cited by applicant]
WO WO2002079415 · 2002 [cited by applicant]
WO WO2002090526 · 2002 [cited by applicant]
WO WO2002090566 · 2002 [cited by applicant]
WO WO2002102993 · 2002 [cited by applicant]
WO WO2002102994 · 2002 [cited by applicant]
WO WO2003015697 · 2003 [cited by applicant]
WO WO2003048334 · 2003 [cited by applicant]
WO WO2003050531 · 2003 [cited by applicant]
WO WO2003059245 · 2003 [cited by applicant]
WO WO2004018649 · 2004 [cited by applicant]
WO WO2004051268 · 2004 [cited by applicant]
WO WO2004055056 · 2004 [cited by applicant]
WO WO2004094613 · 2004 [cited by applicant]
WO WO2004097047 · 2004 [cited by applicant]
WO WO2004106377 · 2004 [cited by applicant]
WO WO2005003169 · 2005 [cited by applicant]
WO WO2005003170 · 2005 [cited by applicant]
WO WO2005003171 · 2005 [cited by applicant]
WO WO2005007121 · 2005 [cited by applicant]
WO WO2005016969 · 2005 [cited by applicant]
WO WO2005021592 · 2005 [cited by applicant]
WO WO2005063808 · 2005 [cited by applicant]