Granted Patent B2

US 12,257,338 · App. 17/273,492 · Granted Mar 25, 2025

Inventors: Ariya Akthakul (Boston, MA); Nithin Ramadurai (Wakefield, MA)

Assignee: Shiseido Company, Limited

A61K8/895A61K8/0204A61K8/25A61K9/0014A61K31/80A61K45/06A61Q19/00A61K2800/882A61K2800/95

Abstract

Claims (28)

1. A composition for the formation of a film over the skin of a subject, comprising:

a. a bifunctional organopolysiloxane polymer selected from a group consisting of monovinyl monophenyl monohydride dimethicone, vinylmethylsiloxane-dimethylsiloxane copolymer (hydride terminated), and monovinyl monohydride dimethicone;

b. a reinforcing constituent suitable for formation of a film on the subject's skin; and

c. an organopolysiloxane with at least two alkenyl functional groups or at least one alkynyl functional group, either at a terminal of the organopolysiloxane or at a side chain of the organopolysiloxane or both; and

wherein the bifunctional organopolysiloxane polymer is present in an amount of from about 1% to about 10% by weight of the total weight of the composition.

2. The composition of claim 1 , wherein the vinyl group or the hydride group are terminal groups.

3. The composition of claim 1 , wherein the bifunctional organopolysiloxane polymer has a degree of polymerization of at least 20 and a dispersity index of less than about 1.2.

4. The composition of claim 3 , wherein the degree of polymerization is from about 20 to about 200.

5. The composition of claim 1 , wherein the film has no crosslinking.

6. The composition of claim 5 , wherein the film is formed via hydrosilylation step-growth polymerization of the bifunctional organopolysiloxane polymer.

7. The composition of claim 5 , wherein the bifunctional organopolysiloxane polymer is capable of reacting with a metal catalyst to form the film over the subject's skin.

8. The composition of claim 7 , wherein the metal catalyst is a platinum catalyst.

9. The composition of claim 1 , wherein the reinforcing constituent is fumed silica.

10. The composition of claim 1 , further comprising an agent, wherein the agent is anti-oxidants, vitamins, vitamin D3 analogues, retinoids, minerals, mineral oil, petroleum jelly, fatty acids, plant extracts, polypeptides, antibodies, proteins, sugars, humectants, emollients, or a combination thereof.

11. The composition of claim 1 , further comprising an agent, wherein the agent is a cosmetic agent.

12. The composition of claim 11 , wherein the cosmetic agent is a moisturizer, a sunscreen, a UV protecting agent, a skin-protectant agent, a skin-soothing agent, a skin-lightening agent, a skin-brightening agent, a skin-softening agent, a skin-smoothening agent, a skin-bleaching agent, a skin-exfoliating agent, a skin-tightening agent, a cosmeceutical agent, a vitamin, an anti-oxidant, a cell-signaling agent, a cell-modulating agent, a cell-interacting agent, a skin tanning agent, an anti-aging agent, an anti-wrinkle agent, a spot reducer, an alpha-hydroxy acid, a beta-hydroxy acid, a ceramide, or a combination thereof.

13. The composition of claim 1 , wherein said reinforcing constituent is selected from the group consisting of surface treated mica, zinc oxide, titanium dioxide, aluminum oxide, clay, and silica.

14. A kit for the formation of a film over the skin of a subject, wherein the kit comprises a) a first container comprising the composition of claim 1 ; and b) a second container comprising metal catalyst.

15. The composition of claim 1 , wherein the bifunctional organopolysiloxane polymer is monovinyl monophenyl monohydride dimethicone.

16. The composition of claim 1 , wherein the bifunctional organopolysiloxane polymer is vinylmethylsiloxane-dimethylsiloxane copolymer (hydride terminated).

17. The composition of claim 1 , wherein the bifunctional organopolysiloxane polymer is monovinyl monohydride dimethicone.

18. The composition of claim 17 , wherein the monovinyl monohydride dimethicone has formula

19. The composition of claim 1 , wherein the bifunctional organopolysiloxane polymer is present in an amount of about 1%, about 2.5%, about 3%, about 5%, about 7%, or about 10% by weight of the total weight of the composition.

20. The composition of claim 1 , wherein the organopolysiloxane with at least two alkenyl functional groups or at least one alkynyl functional group has formula (I):

wherein at least two of R 1 , R 4 , R 5 and R 8 are alkenyl groups or at least one of R 1 , R 4 , R 5 and R 8 is alkynyl group;

the rest of R 1 , R 4 , R 5 and R 8 are C 1-20 alkyl groups;

R 2 , R 3 , R 6 and R 7 are C 1-20 alkyl groups; and

the sum of n and m is between 2 and 1,000,000.

Assignments (3)

Continuity (2)

References Cited (207)