Granted Patent
B2
US 12,025,622 · App. 17/322,604 · Granted Jul 2, 2024
Use and treatment of di-amino acid repeat-containing proteins associated with ALS
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Abstract
Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
Claims (3)
1. A method of producing an antibody, the method comprising administering to a subject a poly-(Pro-Ala) di-amino acid repeat-containing protein.
2. The method of claim 1 , wherein the poly-(Pro-Ala) di-amino acid repeat-containing protein comprises the sequence set forth in SEQ ID NO: 20.
3. The method of claim 1 , further comprising the step of isolating the antibody from the subject.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Dec 5, 2023
From: UNIVERSITY OF FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065775/0205 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 25, 2021
From: RANUM, LAURA; ZU, TAO
To: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
Reel/Frame 057280/0377 →
Continuity (6)
Division
14775278
Provisional Application
61883219
· Sep 27, 2013
Provisional Application
61786258
· Mar 14, 2013