Granted Patent B2

US 12,685,851 · App. 17/380,415 · Granted Jul 21, 2026

Inventors: Daniel J. Abrams (Denver, CO); Matias Maturana (Melbourne, AU)

Assignee: Biogen MA Inc.

A61M27/006A61B5/293A61B5/6852A61B5/6864A61B5/6868A61M25/0026A61M39/0247A61M2039/0273A61M2039/0276

Abstract

Claims (50)

1 . A device or system for delivering fluid to or removing fluid from a cerebrospinal fluid (CSF)-containing space of a brain and for recording electrical brain state activity from white or grey matter in the brain, the device or system comprising:

a CSF catheter comprising a proximal end, a distal end portion, and a first lumen extending from the proximal end to the distal end portion; and

a brain lead extending from and coupled to the CSF catheter by a snap fit connector comprising at least one deflectable element configured to resiliently deflect as at least one of the brain lead or the CSF catheter is inserted, the brain lead comprising an electrode positioned a distance from the distal end of the CSF catheter such that the electrode is configured to contact white or grey matter of the brain when the distal end of the CSF catheter is placed in the CSF-containing space;

signal processing electronics configured to operably couple to the brain lead and to record electrical activity detected by the electrode and to determine a brain state or to predict a future brain state; and

an external apparatus configured to wirelessly receive signals associated with the recorded electrical activity from the signal processing electronics.

2 . The device or system of claim 1 , wherein the CSF-containing space is a lateral ventricle.

3 . The device or system of claim 2 , wherein the electrode is positioned a distance from about 0.5 centimeters to about 6 centimeters to the distal end of the CSF catheter.

4 . The device or system of claim 2 , wherein the electrode is positioned a distance from about 1 centimeter to about 5 centimeters to the distal end of the CSF catheter.

5 . The device or system of claim 2 , wherein the electrode is positioned a distance from about 2 centimeters to about 6 centimeters to the distal end of the CSF catheter.

6 . The device or system of claim 1 , wherein the brain lead is coupled relative to the CSF catheter at the distal end portion of the CSF catheter.

7 . The device or system of claim 1 , wherein the brain lead is secured to the CSF catheter along a substantial length of the CSF catheter.

8 . The device or system of claim 1 , comprising a brain signal electrical interconnect, wherein the brain signal electrical interconnect comprises a contact electrically coupled to the electrode through the brain lead.

9 . The device or system of claim 8 , wherein the CSF catheter comprises the brain signal electrical interconnect.

10 . The device or system of claim 8 , wherein the brain lead comprises the brain signal electrical interconnect.

11 . The device or system of claim 8 , wherein the brain signal electrical interconnect is physically separate from the brain lead.

12 . The device or system of claim 11 , further comprising a cable extending from the brain lead to the brain signal electrical interconnect, wherein the cable comprises a conductor electrically connecting the electrode to the contact.

13 . The device or system of claim 1 , further comprising an access port having a first fluid flow path in communication with the first lumen of the CSF catheter or having a connector configured to secure the CSF catheter such that first lumen is in communication with the first fluid flow path.

14 . The device or system of claim 13 , wherein the access port is configured to be implanted below a scalp.

15 . The device or system of claim 14 , wherein at least a portion of the access port is configured to be implanted over a burr hole.

16 . The device or system of claim 14 , wherein at least a portion of the access port is configured to be implanted in a burr hole.

17 . The device or system of claim 1 , further comprising an implantable infusion device, wherein the implantable infusion device comprises at least a portion of the signal processing electronics.

18 . The device or system of claim 1 , wherein the cranial catheter is an external ventricular drainage catheter or a ventriculoperitoneal shunt.

19 . The device or system of claim 1 , wherein the signal processing electronics are further configured to apply brain stimulative electrical signals to a stimulating electrode coupled to the CSF catheter.

20 . The device or system of claim 1 , wherein the signal processing electronics are further configured to wirelessly transmit the signals to the external apparatus through a portion of a scalp.

21 . The device or system of claim 1 , wherein the external apparatus is further configured to wirelessly power the signal processing electronics using inductive coupling.

22 . The device or system of claim 1 , wherein the brain lead is coupled to the CSF catheter by a snap fit connector comprising a first opening and a second opening.

23 . The device or system of claim 22 , wherein the second opening is symmetrical to the first opening.

24 . The device or system of claim 22 , wherein the first opening is configured to engage the brain lead and the second opening is configured to engage the CSF catheter.

25 . The device or system of claim 1 , wherein the brain lead is coupled to the CSF catheter by a sleeve.

26 . The device or system of claim 1 , wherein the snap fit connector comprises a first set of deflectable elements and a second set of deflectable elements.

27 . The device or system of claim 26 , wherein the first set of deflectable elements is configured to engage the brain lead and the second set of deflectable elements is configured to engage the CSF catheter.

28 . A device or system comprising:

an implantable access port, the access port comprising:

an opening accessible by a needle when the access port is implanted;

a first catheter connector;

a second catheter connector;

a first fluid flow path extending from the opening to the first catheter connector; and

a second fluid flow path extending from the second catheter connector to the first catheter connector;

a CSF catheter coupled to, or operably couplable to, the first catheter connector, the CSF catheter comprising a proximal end, a distal end portion, and first and second lumens extending from the proximal end to the distal portion of the CSF catheter;

a brain lead extending from and coupled to the CSF catheter by a snap fit connector comprising at least one deflectable element configured to resiliently deflect as at least one of the brain lead or the CSF catheter is inserted, the brain lead comprising an electrode configured to detect electrical activity determinative of a brain state or predictive of a future brain state,

wherein the first lumen is in communication with the first fluid flow path and the second lumen is in communication with the second fluid flow path when the proximal end of the CSF catheter is coupled to the first catheter connector,

wherein the CSF catheter has a length such that a distal end is configured to extend to a CSF-containing space of a subject when the access port is implanted,

wherein the electrode is positioned a distance from the distal end of the CSF catheter and configured to be positioned in white or grey matter of a brain of the subject when the access port is implanted and the distal end of the CSF catheter is positioned in the CSF-containing space;

signal processing electronics configured to operably couple to the brain lead and to record electrical activity detected by the electrode and to determine a brain state or to predict a future brain state; and

an external apparatus configured to wirelessly receive signals associated with the recorded electrical activity from the signal processing electronics.

29 . The device or system of claim 28 , wherein the signal processing electronics are further configured to apply brain stimulative electrical signals to a stimulating electrode coupled to the CSF catheter.

30 . The device or system of claim 29 , wherein the stimulating electrode is the brain lead electrode.

31 . The device or system of claim 28 , wherein the second fluid flow path comprises a microbial filter.

32 . The device or system of claim 28 , wherein the signal processing electronics are further configured to wirelessly transmit the signals to the external apparatus through a portion of a scalp of the subject.

33 . The device or system of claim 28 , wherein the external apparatus is further configured to wirelessly power the signal processing electronics using inductive coupling.

Assignments (2)

Continuity (2)

References Cited (400)