IP Library › Granted Patent US 12,360,074
Granted Patent B2
US 12,360,074 · App. 17/390,668 · Granted Jul 15, 2025

Enzyme immobilized adhesive layer for analyte sensors

Inventors: Ted Tang Lee (San Diego, CA); Shanger Wang (Castro Valley, CA); Jiong Zou (San Diego, CA)
Assignee: DEXCOM, INC.
G01N27/3273A61B5/0004A61B5/14532A61B5/14546A61B5/1473A61B5/1486A61B5/14865A61K31/045A61K31/137A61K31/46A61K31/465A61K31/485A61K31/515A61K31/56A61K33/00A61K36/185A61K38/28C08L39/06C08L69/00C08L75/04C12N11/08C12N11/089C12N11/093C12Q1/002C12Q1/006G01N27/40G01N33/66A61B5/002A61B2562/12
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Quick Facts
Patent No.
US 12,360,074
App. No.
17/390,668
Granted
Jul 15, 2025
Kind
B2
Abstract

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

Claims (38)

1. A device for measurement of a concentration of an analyte, the device comprising:

a sensor configured to generate a signal associated with the concentration of the analyte in interstitial fluid; and

a sensing membrane located over the sensor, the sensing membrane comprising:

a first layer, wherein the first layer comprises an enzyme and a first-layer polymer that retains at least 80% of an initial enzyme loading of the enzyme when contacted with an aqueous solution for 1 hour at about 25° C., and wherein the first-layer polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units, and wherein at least one of the zwitterionic repeating units is an internal zwitterionic repeating unit in a backbone of the first-layer polymer and the at least one of the zwitterionic repeating units compromises a betaine compound or a precursor thereof.

2. The device of claim 1 , wherein the first-layer polymer further comprises one or more ionic or non-ionic emulsion stabilizing agents selected from carboxylic acid diols, polyethyleneoxide diol, or polyoxazoline.

3. The device of claim 1 , wherein the one or more zwitterionic repeating units comprise at least one moiety selected from the group consisting of a carboxyl betaine, a sulfo betaine, a phosphor betaine, and derivatives thereof.

4. The device of claim 1 , wherein the one or more zwitterionic repeating units are derived from a monomer selected from the group consisting of:

where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl; R 1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 2 is selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; R 3 is selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heteroncycloalkyl, aryl, and heteroaryl; R 4 is selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and wherein one or more of R 1 , R 2 , R 3 , R 4 , and Z are substituted with a polymerization group.

5. The device of claim 1 , wherein the one or more zwitterionic repeating units are derived from a monomer selected from the group consisting of:

where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl; R 1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 2 is selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and R 3 is selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein one or more of R 1 , R 2 , R 3 , and Z are substituted with a polymerization group.

6. The device of claim 1 , wherein the one or more zwitterionic repeating units are derived from a monomer selected from the group consisting of:

where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl; R 1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R 2 is selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and R 3 is selected from the group consisting of alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; wherein one or more of R 1 , R 2 , R 3 , and Z are substituted with a polymerization group.

7. The device of claim 4 , wherein the polymerization group is selected from alkene, alkyne, epoxide, lactone, amine, hydroxyl, isocyanate, carboxylic acid, anhydride, silane, halide, aldehyde, and carbodiimide.

8. The device of claim 1 , wherein the one or more zwitterionic repeating units are at least 10 wt. % based on the total weight of the first-layer polymer.

9. The device of claim 1 , wherein the polyurethane and/or polyurea segments excluding zwitterionic repeating units are from 15 wt. % to 99 wt. %, based on the total weight of the first-layer polymer.

10. The device of claim 1 , wherein the first-layer polymer further comprises a polyethylene oxide segment.

11. The device of claim 10 , wherein the polyethylene oxide segment is from 5 wt. % to 60 wt. %, based on the total weight of the first-layer polymer.

12. The device of claim 1 , wherein the first-layer polymer has a molecular weight of from 10 kDa to 500,000 kDa.

13. The device of claim 1 , wherein the enzyme is glucose oxidase.

14. The device of claim 1 , wherein the enzyme is galactose oxidase, cholesterol oxidase, amino acid oxidase, alcohol oxidase, lactate oxidase, or uricase.

15. The device of claim 1 , further comprising a base polymer, wherein the base polymer comprises a polyurethane.

16. The device of claim 15 , wherein the base polymer is a polyurethane copolymer chosen from a polyether-urethane-urea, a polycarbonate-urethane, a polyetherurethane, a silicone-polyether-urethane, a silicone-polycarbonate-urethane, or a polyesterurethane.

17. The device of claim 1 , further comprising a base polymer, wherein the base polymer comprises a polymer selected from silicones, epoxies, polyolefins, polystyrenes, polyoxymethylenes, polysiloxanes, polyethers, polyacrylics, polymethacrylic, polyesters, polycarbonates, polyamides, poly(ether ketone)s, or poly(ether imide)s.

18. The device of claim 1 , further comprising an enzyme stabilizing reagent.

19. The device of claim 18 , wherein the enzyme stabilizing reagent comprises one or more zwitterions chosen from cocamidopropyl betaine, oleamidopropyl betaine, octyl sulfobetaine, caprylyl sulfobetaine, lauryl sulfobetaine, myristyl sulfobetaine, palmityl sulfobetaine, stearyl sulfobetaine, betaine (trimethylglycine), octyl betaine, phosphatidylcholine, glycine betaine, poly(carboxybetaine), or poly(sulfobetaine).

20. The device of claim 18 , wherein the enzyme stabilizing reagent comprises bioagents chosen from albumin, chitosan, or hyaluronate.

21. The device of claim 1 , further comprising a crosslinker or several crosslinkers, where in the crosslinker or the several crosslinkers comprise a polymer or oligomer selected from polyfunctional isocynate, polyfunctional aziridine, or polyfunctional carbodiimide.

22. The device of claim 1 , wherein the first layer is from 0.01 μm to 250 μm thick.

23. The device of claim 1 , wherein the sensor comprises an electrode.

24. The device of claim 1 , wherein the device is configured for continuous measurement of the concentration of the analyte.

25. The device of claim 1 , wherein the analyte is glucose.

26. The device of claim 1 , wherein the sensing membrane further comprises a second layer, the second layer including at least one of a pharmaceutical agent or a bioactive agent, wherein the second layer is configured to release the at least one of the pharmaceutical agent or the bioactive agent to reduce or delay inflammation.

27. The device of claim 8 , wherein the one or more zwitterionic repeating units are at least 30 wt. % based on the total weight of the first-layer polymer.

28. The device of claim 1 , wherein the sensing membrane is configured to be free of direct contact with biological fluid.

29. A device for measurement of a concentration of an analyte, the device comprising:

a sensor configured to generate a signal associated with the concentration of the analyte in interstitial fluid; and

a sensing membrane located over the sensor, the sensing membrane comprising: a first layer, wherein the first layer comprises an enzyme and a first-layer polymer that retains at least 50% of initial sensor sensitivity when exposed to 70° C. and 95% relative humidity conditions for up to 24 hours treatment, and the first-layer polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units wherein at least one zwitterionic repeating unit is an internal zwitterionic repeating unit in a backbone of the first-layer polymer, and the at least one zwitterionic repeating unit comprises betaine compound or a precursor thereof.

30. The device of claim 29 , wherein the sensing membrane further comprises a second layer, the second layer including at least one of a pharmaceutical agent or a bioactive agent, wherein the second layer is configured to release the at least one of the pharmaceutical agent or the bioactive agent to reduce or delay inflammation.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2024
From: LEE, TED TANG; WANG, SHANGER; ZOU, JIONG
To: DEXCOM, INC.
Reel/Frame 066526/0341 →
Continuity (5)
Continuation 15394520 · Dec 29, 2016
Provisional Application 62273155 · Dec 30, 2015
Provisional Application 62273142 · Dec 30, 2015
Provisional Application 62273219 · Dec 30, 2015
Related Publication 20210356420A1 · Nov 18, 2021
References Cited (400)
US 493007A · Bartholomew · 1893 [cited by applicant]
US 4431004A · Bessman et al. · 1984 [cited by applicant]
US 4506680A · Stokes · 1985 [cited by applicant]
US 4703756A · Gough et al. · 1987 [cited by applicant]
US 4757022A · Shults et al. · 1988 [cited by applicant]
US 4861830A · Ward, Jr. · 1989 [cited by applicant]
US 4939007A · Hu et al. · 1990 [cited by applicant]
US 4994167A · Shults et al. · 1991 [cited by applicant]
US 5164424A · Brueschke et al. · 1992 [cited by applicant]
US 5282844A · Stokes et al. · 1994 [cited by applicant]
US 5428123A · Ward et al. · 1995 [cited by applicant]
US 5458631A · Xavier · 1995 [cited by applicant]
US 5494562A · Maley et al. · 1996 [cited by applicant]
US 5569462A · Martinson et al. · 1996 [cited by applicant]
US 5605152A · Slate et al. · 1997 [cited by applicant]
US 5820589A · Torgerson et al. · 1998 [cited by applicant]
US 5846558A · Nielsen et al. · 1998 [cited by applicant]
US 5964745A · Lyles et al. · 1999 [cited by applicant]
US 5972369A · Roorda et al. · 1999 [cited by applicant]
US 5976529A · Navia et al. · 1999 [cited by applicant]
US 5985129A · Gough et al. · 1999 [cited by applicant]
US 6001067A · Shults et al. · 1999 [cited by applicant]
US 6015572A · Lin et al. · 2000 [cited by applicant]
US 6083523A · Dionne et al. · 2000 [cited by applicant]
US 6119028A · Schulman et al. · 2000 [cited by applicant]
US 6120676A · Heller et al. · 2000 [cited by applicant]
US 6122536A · Sun et al. · 2000 [cited by applicant]
US 6141573A · Kurnik et al. · 2000 [cited by applicant]
US 6212416B1 · Ward et al. · 2001 [cited by applicant]
US 6281015B1 · Mooney et al. · 2001 [cited by applicant]
US 6400974B1 · Lesho · 2002 [cited by applicant]
US 6405066B1 · Essenpreis et al. · 2002 [cited by applicant]
US 6424847B1 · Mastrototaro et al. · 2002 [cited by applicant]
US 6432362B1 · Shinar et al. · 2002 [cited by applicant]
US 6469998B1 · Burgaleta Salinas et al. · 2002 [cited by applicant]
US 6477395B2 · Schulman et al. · 2002 [cited by applicant]
US 6484046B1 · Say et al. · 2002 [cited by applicant]
US 6512939B1 · Colvin et al. · 2003 [cited by applicant]
US 6514718B2 · Heller et al. · 2003 [cited by applicant]
US 6542765B1 · Guy et al. · 2003 [cited by applicant]
US 6558321B1 · Burd et al. · 2003 [cited by applicant]
US 6565509B1 · Say et al. · 2003 [cited by applicant]
US 6579690B1 · Bonnecaze et al. · 2003 [cited by applicant]
US 6595919B2 · Berner et al. · 2003 [cited by applicant]
US 6702857B2 · Brauker et al. · 2004 [cited by applicant]
US 6741877B1 · Shults et al. · 2004 [cited by applicant]
US 6862465B2 · Shults et al. · 2005 [cited by applicant]
US 6931327B2 · Goode, Jr. et al. · 2005 [cited by applicant]
US 6932894B2 · Mao et al. · 2005 [cited by applicant]
US 7034061B1 · Luthra et al. · 2006 [cited by applicant]
US 7074307B2 · Simpson et al. · 2006 [cited by applicant]
US 7081195B2 · Simpson et al. · 2006 [cited by applicant]
US 7108778B2 · Simpson et al. · 2006 [cited by applicant]
US 7110803B2 · Shults et al. · 2006 [cited by applicant]
US 7134999B2 · Brauker et al. · 2006 [cited by applicant]
US 7136689B2 · Shults et al. · 2006 [cited by applicant]
US 7157528B2 · Ward · 2007 [cited by applicant]
US 7192450B2 · Brauker et al. · 2007 [cited by applicant]
US 7226978B2 · Tapsak et al. · 2007 [cited by applicant]
US 7276029B2 · Goode, Jr. et al. · 2007 [cited by applicant]
US 7310544B2 · Brister et al. · 2007 [cited by applicant]
US 7364592B2 · Carr-Brendel et al. · 2008 [cited by applicant]
US 7366556B2 · Brister et al. · 2008 [cited by applicant]
US 7379765B2 · Petisce et al. · 2008 [cited by applicant]
US 7424318B2 · Brister et al. · 2008 [cited by applicant]
US 7445792B2 · Toner et al. · 2008 [cited by applicant]
US 7460898B2 · Brister et al. · 2008 [cited by applicant]
US 7467003B2 · Brister et al. · 2008 [cited by applicant]
US 7471972B2 · Rhodes et al. · 2008 [cited by applicant]
US 7494465B2 · Brister et al. · 2009 [cited by applicant]
US 7497827B2 · Brister et al. · 2009 [cited by applicant]
US 7519408B2 · Rasdal et al. · 2009 [cited by applicant]
US 7583990B2 · Goode, Jr. et al. · 2009 [cited by applicant]
US 7591801B2 · Brauker et al. · 2009 [cited by applicant]
US 7599726B2 · Goode, Jr. et al. · 2009 [cited by applicant]
US 7613491B2 · Boock et al. · 2009 [cited by applicant]
US 7615007B2 · Shults et al. · 2009 [cited by applicant]
US 7632228B2 · Brauker et al. · 2009 [cited by applicant]
US 7637868B2 · Saint et al. · 2009 [cited by applicant]
US 7640048B2 · Dobbles et al. · 2009 [cited by applicant]
US 7651596B2 · Petisce et al. · 2010 [cited by applicant]
US 7654956B2 · Brister et al. · 2010 [cited by applicant]
US 7657297B2 · Simpson et al. · 2010 [cited by applicant]
US 7670470B2 · Mao et al. · 2010 [cited by applicant]
US 7699964B2 · Feldman et al. · 2010 [cited by applicant]
US 7711402B2 · Shults et al. · 2010 [cited by applicant]
US 7713574B2 · Brister et al. · 2010 [cited by applicant]
US 7715893B2 · Kamath et al. · 2010 [cited by applicant]
US 7761130B2 · Simpson et al. · 2010 [cited by applicant]
US 7771352B2 · Shults et al. · 2010 [cited by applicant]
US 7774145B2 · Brauker et al. · 2010 [cited by applicant]
US 7775975B2 · Brister et al. · 2010 [cited by applicant]
US 7778680B2 · Goode, Jr. et al. · 2010 [cited by applicant]
US 7783333B2 · Brister et al. · 2010 [cited by applicant]
US 7792562B2 · Shults et al. · 2010 [cited by applicant]
US 7797028B2 · Goode, Jr. et al. · 2010 [cited by applicant]
US 7826981B2 · Goode, Jr. et al. · 2010 [cited by applicant]
US 7828728B2 · Boock et al. · 2010 [cited by applicant]
US 7831287B2 · Brister et al. · 2010 [cited by applicant]
US 7835777B2 · Shults et al. · 2010 [cited by applicant]
US 7857760B2 · Brister et al. · 2010 [cited by applicant]
US 7860545B2 · Shults et al. · 2010 [cited by applicant]
US 7871456B2 · Gough et al. · 2011 [cited by applicant]
US 7875293B2 · Shults et al. · 2011 [cited by applicant]
US 7879444B2 · Jiang et al. · 2011 [cited by applicant]
US 7881763B2 · Brauker et al. · 2011 [cited by applicant]
US 7885697B2 · Brister et al. · 2011 [cited by applicant]
US 7896809B2 · Simpson et al. · 2011 [cited by applicant]
US 7899511B2 · Shults et al. · 2011 [cited by applicant]
US 7901354B2 · Shults et al. · 2011 [cited by applicant]
US 7905833B2 · Brister et al. · 2011 [cited by applicant]
US 7914450B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 7917186B2 · Kamath et al. · 2011 [cited by applicant]
US 7920906B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 7925321B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 7927274B2 · Rasdal et al. · 2011 [cited by applicant]
US 7933639B2 · Goode et al. · 2011 [cited by applicant]
US 7935057B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 7946984B2 · Brister et al. · 2011 [cited by applicant]
US 7949381B2 · Brister et al. · 2011 [cited by applicant]
US 7955261B2 · Goode et al. · 2011 [cited by applicant]
US 7959569B2 · Goode et al. · 2011 [cited by applicant]
US 7970448B2 · Shults et al. · 2011 [cited by applicant]
US 7974672B2 · Shults et al. · 2011 [cited by applicant]
US 7976492B2 · Brauker et al. · 2011 [cited by applicant]
US 7979104B2 · Kamath et al. · 2011 [cited by applicant]
US 7986986B2 · Goode et al. · 2011 [cited by applicant]
US 7998071B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 8000901B2 · Brauker et al. · 2011 [cited by applicant]
US 8005524B2 · Brauker et al. · 2011 [cited by applicant]
US 8005525B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 8010174B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 8050731B2 · Tapsak et al. · 2011 [cited by applicant]
US 8052601B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 8053018B2 · Tapsak et al. · 2011 [cited by applicant]
US 8060173B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 8060174B2 · Simpson et al. · 2011 [cited by applicant]
US 8064977B2 · Boock et al. · 2011 [cited by applicant]
US 8073519B2 · Goode, Jr. et al. · 2011 [cited by applicant]
US 8073520B2 · Kamath et al. · 2011 [cited by applicant]
US 8101156B2 · Pacetti · 2012 [cited by applicant]
US 8103456B2 · Doniger et al. · 2012 [cited by applicant]
US 8118877B2 · Brauker et al. · 2012 [cited by applicant]
US 8128562B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8133178B2 · Brauker et al. · 2012 [cited by applicant]
US 8147666B2 · Mao et al. · 2012 [cited by applicant]
US 8150488B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8155722B2 · Feldman et al. · 2012 [cited by applicant]
US 8155723B2 · Shults et al. · 2012 [cited by applicant]
US 8160669B2 · Brauker et al. · 2012 [cited by applicant]
US 8160671B2 · Kamath et al. · 2012 [cited by applicant]
US 8167801B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8170803B2 · Kamath et al. · 2012 [cited by applicant]
US 8195265B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8206297B2 · Kamath et al. · 2012 [cited by applicant]
US 8216139B2 · Brauker et al. · 2012 [cited by applicant]
US 8224415B2 · Budiman · 2012 [cited by applicant]
US 8229534B2 · Brister et al. · 2012 [cited by applicant]
US 8229535B2 · Mensinger et al. · 2012 [cited by applicant]
US 8229536B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8231531B2 · Brister et al. · 2012 [cited by applicant]
US 8233958B2 · Brauker et al. · 2012 [cited by applicant]
US 8233959B2 · Kamath et al. · 2012 [cited by applicant]
US 8249684B2 · Kamath et al. · 2012 [cited by applicant]
US 8251906B2 · Brauker et al. · 2012 [cited by applicant]
US 8255030B2 · Petisce et al. · 2012 [cited by applicant]
US 8255032B2 · Petisce et al. · 2012 [cited by applicant]
US 8255033B2 · Petisce et al. · 2012 [cited by applicant]
US 8257259B2 · Brauker et al. · 2012 [cited by applicant]
US 8260393B2 · Kamath et al. · 2012 [cited by applicant]
US 8265725B2 · Brauker et al. · 2012 [cited by applicant]
US 8275437B2 · Brauker et al. · 2012 [cited by applicant]
US 8275438B2 · Simpson et al. · 2012 [cited by applicant]
US 8277713B2 · Petisce et al. · 2012 [cited by applicant]
US 8280475B2 · Brister et al. · 2012 [cited by applicant]
US 8282549B2 · Brauker et al. · 2012 [cited by applicant]
US 8282550B2 · Rasdal et al. · 2012 [cited by applicant]
US 8285354B2 · Goode et al. · 2012 [cited by applicant]
US 8287453B2 · Li et al. · 2012 [cited by applicant]
US 8290559B2 · Shariati et al. · 2012 [cited by applicant]
US 8290560B2 · Kamath et al. · 2012 [cited by applicant]
US 8290561B2 · Brauker et al. · 2012 [cited by applicant]
US 8290562B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8292810B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8298142B2 · Simpson et al. · 2012 [cited by applicant]
US 8311749B2 · Brauker et al. · 2012 [cited by applicant]
US 8313434B2 · Brister et al. · 2012 [cited by applicant]
US 8321149B2 · Brauker et al. · 2012 [cited by applicant]
US 8332008B2 · Goode et al. · 2012 [cited by applicant]
US 8346338B2 · Goode, Jr. et al. · 2013 [cited by applicant]
US 8364229B2 · Simpson et al. · 2013 [cited by applicant]
US 8369919B2 · Kamath et al. · 2013 [cited by applicant]
US 8374667B2 · Brauker et al. · 2013 [cited by applicant]
US 8380274B2 · Mao et al. · 2013 [cited by applicant]
US 8386004B2 · Kamath et al. · 2013 [cited by applicant]
US 8394021B2 · Goode et al. · 2013 [cited by applicant]
US 8574660B2 · Weaver et al. · 2013 [cited by applicant]
US 8583204B2 · Boock et al. · 2013 [cited by applicant]
US 8632838B2 · Roth et al. · 2014 [cited by applicant]
US 8682408B2 · Boock et al. · 2014 [cited by applicant]
US 8721870B2 · Oviatt, Jr. et al. · 2014 [cited by applicant]
US 9085790B2 · Hoss et al. · 2015 [cited by applicant]
US 9244064B2 · Muller et al. · 2016 [cited by applicant]
US 9394435B2 · Jiang et al. · 2016 [cited by applicant]
US 9737250B2 · Hughes et al. · 2017 [cited by applicant]
US 9788765B2 · Boock et al. · 2017 [cited by applicant]
US 9936909B2 · Boock et al. · 2018 [cited by applicant]
US 10045273B2 · Mahler et al. · 2018 [cited by applicant]
US 10045723B2 · Boock et al. · 2018 [cited by applicant]
US 10413227B2 · Hughes et al. · 2019 [cited by applicant]
US 11112377B2 · Wang et al. · 2021 [cited by applicant]
US 20010054319A1 · Heller et al. · 2001 [cited by applicant]
US 20020075844A1 · Hagen · 2002 [cited by applicant]
US 20020077134A1 · Mizell et al. · 2002 [cited by applicant]
US 20020087634A1 · Ogle et al. · 2002 [cited by applicant]
US 20020143968A1 · Banerjee et al. · 2002 [cited by applicant]
US 20020181422A1 · Parantainen et al. · 2002 [cited by applicant]
US 20030000833A1 · Mansouri et al. · 2003 [cited by applicant]
US 20030032874A1 · Rhodes et al. · 2003 [cited by applicant]
US 20030042137A1 · Mao et al. · 2003 [cited by applicant]
US 20030073449A1 · Motegi et al. · 2003 [cited by applicant]
US 20030134100A1 · Mao et al. · 2003 [cited by applicant]
US 20030135569A1 · Khakoo et al. · 2003 [cited by applicant]
US 20030187800A1 · Moore et al. · 2003 [cited by applicant]
US 20030235171A1 · Lundstrom et al. · 2003 [cited by applicant]
US 20040006601A1 · Bernstein et al. · 2004 [cited by applicant]
US 20040025057A1 · Cook · 2004 [cited by applicant]
US 20040199649A1 · Tarnanen et al. · 2004 [cited by applicant]
US 20050013289A1 · Tanimoto · 2005 [cited by applicant]
US 20050020234A1 · Iivari et al. · 2005 [cited by applicant]
US 20050026597A1 · Kim et al. · 2005 [cited by applicant]
US 20050027463A1 · Goode et al. · 2005 [cited by applicant]
US 20050033132A1 · Shults et al. · 2005 [cited by applicant]
US 20050043598A1 · Goode et al. · 2005 [cited by applicant]
US 20050051427A1 · Brauker et al. · 2005 [cited by applicant]
US 20050054909A1 · Petisce et al. · 2005 [cited by applicant]
US 20050056552A1 · Simpson et al. · 2005 [cited by applicant]
US 20050090607A1 · Tapsak et al. · 2005 [cited by applicant]
US 20050095174A1 · Wolf · 2005 [cited by applicant]
US 20050130659A1 · Grech et al. · 2005 [cited by applicant]
US 20050143635A1 · Kamath et al. · 2005 [cited by applicant]
US 20050154271A1 · Rasdal et al. · 2005 [cited by applicant]
US 20050173245A1 · Feldman et al. · 2005 [cited by applicant]
US 20050176136A1 · Burd et al. · 2005 [cited by applicant]
US 20050182451A1 · Griffin et al. · 2005 [cited by applicant]
US 20050192557A1 · Brauker et al. · 2005 [cited by applicant]
US 20050203360A1 · Brauker et al. · 2005 [cited by applicant]
US 20050245795A1 · Goode et al. · 2005 [cited by applicant]
US 20050245799A1 · Brauker et al. · 2005 [cited by applicant]
US 20060004272A1 · Shah et al. · 2006 [cited by applicant]
US 20060015020A1 · Neale et al. · 2006 [cited by applicant]
US 20060016700A1 · Brister et al. · 2006 [cited by applicant]
US 20060020187A1 · Brister et al. · 2006 [cited by applicant]
US 20060020188A1 · Kamath et al. · 2006 [cited by applicant]
US 20060020190A1 · Kamath et al. · 2006 [cited by applicant]
US 20060020191A1 · Brister et al. · 2006 [cited by applicant]
US 20060020192A1 · Brister et al. · 2006 [cited by applicant]
US 20060036140A1 · Brister et al. · 2006 [cited by applicant]
US 20060036143A1 · Brister et al. · 2006 [cited by applicant]
US 20060036145A1 · Brister et al. · 2006 [cited by applicant]
US 20060040402A1 · Brauker et al. · 2006 [cited by applicant]
US 20060068208A1 · Tapsak et al. · 2006 [cited by applicant]
US 20060096858A1 · Hsiung · 2006 [cited by examiner]
US 20060142651A1 · Brister et al. · 2006 [cited by applicant]
US 20060155180A1 · Brister et al. · 2006 [cited by applicant]
US 20060183863A1 · Huang et al. · 2006 [cited by applicant]
US 20060189856A1 · Petisce et al. · 2006 [cited by applicant]
US 20060198864A1 · Shults et al. · 2006 [cited by applicant]
US 20060200020A1 · Brister et al. · 2006 [cited by applicant]
US 20060200022A1 · Brauker et al. · 2006 [cited by applicant]
US 20060200970A1 · Brister et al. · 2006 [cited by applicant]
US 20060204536A1 · Shults et al. · 2006 [cited by applicant]
US 20060222566A1 · Brauker et al. · 2006 [cited by applicant]
US 20060224108A1 · Brauker et al. · 2006 [cited by applicant]
US 20060235285A1 · Brister et al. · 2006 [cited by applicant]
US 20060247855A1 · De Silva et al. · 2006 [cited by applicant]
US 20060249381A1 · Petisce et al. · 2006 [cited by applicant]
US 20060252027A1 · Petisce et al. · 2006 [cited by applicant]
US 20060253012A1 · Petisce et al. · 2006 [cited by applicant]
US 20060257995A1 · Simpson et al. · 2006 [cited by applicant]
US 20060258761A1 · Boock et al. · 2006 [cited by applicant]
US 20060263763A1 · Simpson et al. · 2006 [cited by applicant]
US 20060270922A1 · Brauker et al. · 2006 [cited by applicant]
US 20060270923A1 · Brauker et al. · 2006 [cited by applicant]
US 20060275860A1 · Kjaer et al. · 2006 [cited by applicant]
US 20070016381A1 · Kamath et al. · 2007 [cited by applicant]
US 20070027370A1 · Brauker et al. · 2007 [cited by applicant]
US 20070027385A1 · Brister et al. · 2007 [cited by applicant]
US 20070032706A1 · Kamath et al. · 2007 [cited by applicant]
US 20070032718A1 · Shults et al. · 2007 [cited by applicant]
US 20070034512A1 · Yamaoka et al. · 2007 [cited by applicant]
US 20070045902A1 · Brauker et al. · 2007 [cited by applicant]
US 20070059196A1 · Brister et al. · 2007 [cited by applicant]
US 20070066873A1 · Kamath et al. · 2007 [cited by applicant]
US 20070173709A1 · Petisce et al. · 2007 [cited by applicant]
US 20070173710A1 · Petisce et al. · 2007 [cited by applicant]
US 20070197890A1 · Boock et al. · 2007 [cited by applicant]
US 20070203966A1 · Brauker et al. · 2007 [cited by applicant]
US 20070208245A1 · Brauker et al. · 2007 [cited by applicant]
US 20070208246A1 · Brauker et al. · 2007 [cited by applicant]
US 20070213611A1 · Simpson et al. · 2007 [cited by applicant]
US 20070232879A1 · Brister et al. · 2007 [cited by applicant]
US 20070291670A1 · Pettersson et al. · 2007 [cited by applicant]
US 20080033254A1 · Kamath et al. · 2008 [cited by applicant]
US 20080034972A1 · Gough et al. · 2008 [cited by applicant]
US 20080045824A1 · Tapsak et al. · 2008 [cited by applicant]
US 20080083617A1 · Simpson et al. · 2008 [cited by applicant]
US 20080086044A1 · Brister et al. · 2008 [cited by applicant]
US 20080108942A1 · Brister et al. · 2008 [cited by applicant]
US 20080119703A1 · Brister et al. · 2008 [cited by applicant]
US 20080119704A1 · Brister et al. · 2008 [cited by applicant]
US 20080119706A1 · Brister et al. · 2008 [cited by applicant]
US 20080176271A1 · Silver et al. · 2008 [cited by applicant]
US 20080181861A1 · Jiang et al. · 2008 [cited by applicant]
US 20080183061A1 · Goode et al. · 2008 [cited by applicant]
US 20080183399A1 · Goode et al. · 2008 [cited by applicant]
US 20080188731A1 · Brister et al. · 2008 [cited by applicant]
US 20080189051A1 · Goode et al. · 2008 [cited by applicant]
US 20080194938A1 · Brister et al. · 2008 [cited by applicant]
US 20080197024A1 · Simpson et al. · 2008 [cited by applicant]
US 20080200788A1 · Brister et al. · 2008 [cited by applicant]
US 20080200789A1 · Brister et al. · 2008 [cited by applicant]
US 20080200791A1 · Simpson et al. · 2008 [cited by applicant]
US 20080214910A1 · Buck · 2008 [cited by applicant]
US 20080214915A1 · Brister et al. · 2008 [cited by applicant]
US 20080228054A1 · Shults et al. · 2008 [cited by applicant]
US 20080242961A1 · Brister et al. · 2008 [cited by applicant]
US 20080262469A1 · Brister et al. · 2008 [cited by applicant]
US 20080275313A1 · Brister et al. · 2008 [cited by applicant]
US 20080287765A1 · Rasdal et al. · 2008 [cited by applicant]
US 20080306368A1 · Goode, Jr. et al. · 2008 [cited by applicant]
US 20080306434A1 · Dobbles et al. · 2008 [cited by applicant]
US 20080306435A1 · Kamath et al. · 2008 [cited by applicant]
US 20080306444A1 · Brister et al. · 2008 [cited by applicant]
US 20090018424A1 · Kamath et al. · 2009 [cited by applicant]
US 20090030294A1 · Petisce et al. · 2009 [cited by applicant]
US 20090036758A1 · Brauker et al. · 2009 [cited by applicant]
US 20090036763A1 · Brauker et al. · 2009 [cited by applicant]
US 20090043181A1 · Brauker et al. · 2009 [cited by applicant]
US 20090043182A1 · Brauker et al. · 2009 [cited by applicant]
US 20090043525A1 · Brauker et al. · 2009 [cited by applicant]
US 20090045055A1 · Rhodes et al. · 2009 [cited by applicant]
US 20090062633A1 · Brauker et al. · 2009 [cited by applicant]
US 20090062635A1 · Brauker et al. · 2009 [cited by applicant]
US 20090076360A1 · Brister et al. · 2009 [cited by applicant]
US 20090099433A1 · Staib et al. · 2009 [cited by applicant]
US 20090099436A1 · Brister et al. · 2009 [cited by applicant]
US 20090124877A1 · Goode, Jr. et al. · 2009 [cited by applicant]
US 20090124879A1 · Brister et al. · 2009 [cited by applicant]
US 20090124964A1 · Leach et al. · 2009 [cited by applicant]
US 20090131769A1 · Leach et al. · 2009 [cited by applicant]
US 20090131777A1 · Simpson et al. · 2009 [cited by applicant]
US 20090137886A1 · Shariati et al. · 2009 [cited by applicant]
US 20090137887A1 · Shariati et al. · 2009 [cited by applicant]
US 20090143659A1 · Li et al. · 2009 [cited by applicant]
US 20090143660A1 · Brister et al. · 2009 [cited by applicant]
US 20090156919A1 · Brister et al. · 2009 [cited by applicant]
US 20090163790A1 · Brister et al. · 2009 [cited by applicant]
US 20090178459A1 · Li et al. · 2009 [cited by applicant]
US 20090192366A1 · Mensinger et al. · 2009 [cited by applicant]
US 20090192380A1 · Shariati et al. · 2009 [cited by applicant]
US 20090192722A1 · Shariati et al. · 2009 [cited by applicant]
US 20090192724A1 · Brauker et al. · 2009 [cited by applicant]
US 20090192745A1 · Kamath et al. · 2009 [cited by applicant]
US 20090192751A1 · Kamath et al. · 2009 [cited by applicant]
US 20090203981A1 · Brauker et al. · 2009 [cited by applicant]
US 20090216103A1 · Brister et al. · 2009 [cited by applicant]
US 20090240120A1 · Mensinger et al. · 2009 [cited by applicant]
US 20090240193A1 · Mensinger et al. · 2009 [cited by applicant]
US 20090242399A1 · Kamath et al. · 2009 [cited by applicant]
US 20090242425A1 · Kamath et al. · 2009 [cited by applicant]
US 20090247855A1 · Boock et al. · 2009 [cited by applicant]
US 20090247856A1 · Boock et al. · 2009 [cited by applicant]
US 20090287074A1 · Shults et al. · 2009 [cited by applicant]
US 20090299155A1 · Yang et al. · 2009 [cited by applicant]
US 20090299156A1 · Simpson et al. · 2009 [cited by applicant]
US 20090299162A1 · Brauker et al. · 2009 [cited by applicant]
US 20100010331A1 · Brauker et al. · 2010 [cited by applicant]
US 20100010332A1 · Brauker et al. · 2010 [cited by applicant]
US 20100016687A1 · Brauker et al. · 2010 [cited by applicant]
US 20100016698A1 · Rasdal et al. · 2010 [cited by applicant]
US 20100016838A1 · Butts et al. · 2010 [cited by applicant]
US 20100030484A1 · Brauker et al. · 2010 [cited by applicant]
US 20100036215A1 · Goode, Jr. et al. · 2010 [cited by applicant]
US 20100036225A1 · Goode, Jr. et al. · 2010 [cited by applicant]
US 20100041971A1 · Goode, Jr. et al. · 2010 [cited by applicant]
US 20100045465A1 · Brauker et al. · 2010 [cited by applicant]
US 20100049024A1 · Saint et al. · 2010 [cited by applicant]
US 20100076283A1 · Simpson et al. · 2010 [cited by applicant]
US 20100081908A1 · Dobbles et al. · 2010 [cited by applicant]
US 20100081910A1 · Brister et al. · 2010 [cited by applicant]
US 20100087724A1 · Brauker et al. · 2010 [cited by applicant]
US 20100096259A1 · Zhang et al. · 2010 [cited by applicant]
US 20100099150A1 · Fang et al. · 2010 [cited by applicant]
US 20100121169A1 · Petisce et al. · 2010 [cited by applicant]
US 20100161269A1 · Kamath et al. · 2010 [cited by applicant]
US 20100168381A1 · O'Mahony et al. · 2010 [cited by applicant]
US 20100168540A1 · Kamath et al. · 2010 [cited by applicant]
US 20100168541A1 · Kamath et al. · 2010 [cited by applicant]
US 20100168542A1 · Kamath et al. · 2010 [cited by applicant]