IP Library › Granted Patent US 12,304,934
Granted Patent B2
US 12,304,934 · App. 17/422,736 · Granted May 20, 2025

Recombinant lubricins, and compositions and methods for using the same

Inventors: Matthew Paszek (Lansing, NY); Heidi Reesink (Lansing, NY)
Assignee: Cornell University
C07K14/4727A61L12/14A61P19/02C07K14/4725A61K38/00A61L2101/46C07K2319/02C07K2319/03
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Quick Facts
Patent No.
US 12,304,934
App. No.
17/422,736
Granted
May 20, 2025
Kind
B2
Abstract

Provided are compositions and methods related to modified lubricins, methods of making the modified lubricins, and methods of using the modified lubricins for coating a variety of inanimate objects, and for prophylaxis and/or therapy of disorders where enhanced lubrication of one or more parts of a human or non-human mammal is desirable.

Claims (2)

1. A method of making a recombinant lubricin, said lubricin comprising the sequence KEPAPTTP (SEQ ID NO:1) contiguously repeated 10-120 times, the method comprising introducing into mammalian cells a polynucleotide encoding said recombinant lubricin such that the cells express said recombinant lubricin.

2. The method of claim 1 , further comprising isolating the recombinant lubricin from the mammalian cells.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2025
From: PASZEK, MATTHEW
To: CORNELL UNIVERSITY
Reel/Frame 070366/0182 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2025
From: REESINK, HEIDI
To: CORNELL UNIVERSITY
Reel/Frame 070057/0646 →
Continuity (2)
Provisional Application 62792660 · Jan 15, 2019
Related Publication 20220127318A1 · Apr 28, 2022
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