Granted Patent
B2
US 12,637,411 · App. 17/426,187 · Granted May 26, 2026
Structurally modified opioids for prevention and treatment of diseases and conditions
Inventors:
Paolo L. Manfredi (Miami Beach, FL); Charles E. Inturrisi (New York, NY); Andrea Mattarei (Perarolo di Vigonza, IT); Sara De Martin (Vigonza, IT); Jacopo Sgrignani (Almenno San Salvatore, IT); Andrea Cavalli (Zurich, CH)
C07C225/16C07C225/18C07C229/34C07C323/29C07D207/09C07D209/14C07D233/64C07D295/135C07D317/58C07D319/06C07D333/28C07B2200/05
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Abstract
Aspects of the present invention are directed to structurally modified opioids (SMOs) that result in improved modulating activity at the NMDAR and improved PK and PD parameters over existing drugs with NMDAR modulating activity. The structural modifications of an opioid or opioid enantiomer that result in the SMOs can be obtained by starting the synthetic process de novo; by modifying the synthetic process for the opioid at any intermediate step during the synthesis of the racemate or of one enantiomer; or by modifying the structure of the opioid or opioid enantiomer after the synthesis. The nitric acid ester substitutions are of particular relevance, especially when associated to deuterated substitutions and/or halogen substitutions.
Claims (1)
1 . A compound having a structure analogue to dextromethadone, wherein the compound is selected from the group consisting of:
Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 2, 2022
From: MGGM LLC
To: MANFREDI, PAOLO; INTURRISI, CHARLES
Reel/Frame 059781/0939 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 2, 2022
From: INSTITUTE FOR RESEARCH IN BIOMEDICINE
To: MGGM LLC
Reel/Frame 059843/0891 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 2, 2022
From: UNIVERSITA DEGLI STUDI DI PADOVA
To: MGGM LLC
Reel/Frame 061420/0847 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 26, 2021
From: MANFREDI, PAOLO L.; INTURRISI, CHARLES E.
To: MGGM LLC
Reel/Frame 057909/0388 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 26, 2021
From: SGRIGNANI, JACOPO; CAVALLI, ANDREA
To: INSTITUTE FOR RESEARCH IN BIOMEDICINE
Reel/Frame 057318/0543 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 23, 2021
From: MATTAREI, ANDREA; DE MARTIN, SARA
To: UNIVERSITY OF PADOVA
Reel/Frame 057252/0718 →
Continuity (2)
Provisional Application
62798709
· Jan 30, 2019
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