IP Library › Granted Patent US 12,419,876
Granted Patent B2
US 12,419,876 · App. 17/450,377 · Granted Sep 23, 2025

Treatment of hearing loss by inhibition of casein kinase 1

Inventors: Albert Edge (Brookline, MA); Yenfu Cheng (Boston, MA)
Assignee: Massachusetts Eye and Ear Infirmary
A61K31/4439A61K9/0046A61K31/437A61K38/00A61P27/16C07D401/04C07D403/04C07D405/14C07D413/14C07D487/04C12Q1/485G01N2800/14
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Quick Facts
Patent No.
US 12,419,876
App. No.
17/450,377
Granted
Sep 23, 2025
Kind
B2
Abstract

Methods for treating hearing loss that include administering an inhibitor, e.g., a small molecule inhibitor, of casein kinase 1, preferably in combination with a treatment that stimulates Atoh1 gene expression, e.g., a gamma-secretase inhibitor, an Atoh1 stimulatory compound, or a GSK-3-beta inhibitor.

Claims (16)

1. A method of treating a subject who has or is at risk of developing hearing loss or vestibular dysfunction, the method comprising:

identifying a subject who has experienced, or is at risk for developing, hearing loss or vestibular dysfunction; and

administering to the subject one or more nucleic acids that target casein kinase 1 (CK1) epsilon and/or CK1 delta, and one or more compounds that stimulate Atoh1 gene expression.

2. The method of claim 1 , wherein the subject has or is at risk for developing sensorineural hearing loss, auditory neuropathy, or both.

3. The method of claim 1 , wherein the subject has or is at risk for developing a vestibular dysfunction that results in dizziness, imbalance, or vertigo.

4. The method of claim 1 , wherein the one or more inhibitory nucleic acids that target CK1 epsilon and/or CK1 delta, and/or the one or more compounds that stimulate Atoh1 gene expression is administered systemically.

5. The method of claim 1 , wherein the one or more inhibitory nucleic acids that target CK1 epsilon and/or CK1 delta, and/or the one or more compounds that stimulate Atoh1 gene expression is administered locally to the inner ear.

6. The method of claim 1 , wherein the one or more inhibitory nucleic acids that target CK1 epsilon and/or CK1 delta is shRNA or siRNA.

7. The method of claim 1 , wherein the method comprises administering to the subject one or more inhibitory nucleic acids that target CK1 epsilon.

8. The method of claim 1 , wherein the method comprises administering to the subject one or more inhibitory nucleic acids that target CK1 delta.

9. The method of claim 1 , wherein the one or more compounds that stimulate Atoh1 gene expression comprises a glycogen synthase kinase 3 beta (GSK-3-beta) inhibitor.

10. The method of claim 1 , wherein the one or more compounds that stimulate Atoh1 gene expression comprises a gamma secretase inhibitor.

11. The method of claim 1 , wherein the hearing loss or vestibular dysfunction is caused by aging.

12. The method of claim 1 , wherein the hearing loss or vestibular dysfunction is caused by a genetic or congenital defect.

13. The method of claim 1 , wherein the hearing loss or vestibular dysfunction is caused by noise or trauma.

14. The method of claim 1 , wherein the hearing loss or vestibular dysfunction is caused by a chemical ototoxic insult.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 20, 2021
From: EDGE, ALBERT; CHENG, YENFU
To: MASSACHUSETTS EYE AND EAR INFIRMARY
Reel/Frame 057842/0326 →
Continuity (3)
Division 15781041
Provisional Application 62263412 · Dec 4, 2015
Related Publication 20220016100A1 · Jan 20, 2022
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