Polymer particles
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
1. A polymer particle including:
at least one monomer including at least one functional group; and
at least one crosslinker including at least two functional groups and at least one linkage susceptible to breakage to impart biodegradation to the polymer particle;
wherein the polymer particle has a spherical diameter between about 40 μm and about 1,200 μm, and a circularity greater than about 0.9.
2. The polymer particle of claim 1 , wherein the biodegradation provides less than about 10% of the polymer particle intact after about 5 days.
3. The polymer particle of claim 1 , wherein the spherical diameter is between about 75 μm and about 1,200 μm.
4. The polymer particle of claim 1 , wherein the biodegradation is through hydrolysis or enzymatic action.
5. The polymer particle of claim 1 , wherein the at least one crosslinker is bis-glycidyl amino alcohol,
wherein a, b, c, d, e, and f are each independently 1-20.
6. The polymer particle of claim 1 , wherein the at least one linkage is an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, a peptide cleavable by matrix cathepsins, or a combination thereof.
7. The polymer particle of claim 1 , wherein the at least one crosslinker is bis-glycidyl amino alcohol or bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
8. The polymer particle of claim 1 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.
9. The polymer particle of claim 1 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.
10. The polymer particle of claim 1 , wherein the at least one monomer includes an ionizable functional group.
11. The polymer particle of claim 10 , wherein the ionizable functional group is basic or acidic.
12. The polymer particle of claim 1 , wherein the at least one monomer is dimethylacrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.
13. The polymer particle of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
14. An embolic solution including a plurality of the polymer particle of claim 1 .
15. The embolic solution of claim 14 , wherein the solution is sterilized.
16. The embolic solution of claim 14 , including a radiopaque contrast agent.
17. The embolic solution of claim 14 , including a dye.
18. A method of treatment, the method comprising administering the embolic solution of claim 14 to a location in need thereof.
19. The method of claim 18 , wherein the location is in a vessel.