Granted Patent B2

US 12,337,140 · App. 17/489,620 · Granted Jun 24, 2025

Inventors: Gianna N. Riccardi (South Berwick, ME); William X. Siopes, Jr. (Lowell, MA); Marcie Glicksman (Salem, MA); Anthony DePasqua (Newburyport, MA); Kevin Kalish (Newburyport, MA); Joshua G. Vose (Seattle, WA); Rajan Patel (Somerville, MA)

Assignee: EnClear Therapies, Inc.

A61M5/16827A61M5/145A61M5/16886A61M2005/14208A61M2202/0464A61M2205/3344A61M2205/3389A61M2210/0693

Abstract

Claims (15)

1. A CSF management system for use with a patient having a body with CSF having a natural flow rate, the system comprising:

a catheter configured to at least in part form a closed loop CSF circuit between two points on the body;

a therapeutic inlet to the CSF circuit configured to receive a therapeutic material at a therapeutic rate;

a pump configured to direct CSF carrying the therapeutic material along the CSF circuit; and

a controller operatively coupled with the pump, the controller configured to control the pump to direct the CSF at a CSF rate, the CSF rate being different from the natural flow rate, the controller configured to set the CSF rate to be different from the therapeutic rate, the CSF rate individually controllable separate from the therapeutic rate.

2. The system as defined by claim 1 wherein the CSF rate is a constant rate.

3. The system as defined by claim 1 wherein the CSF rate varies over time.

4. The system as defined by claim 1 wherein the CSF circuit is configured so that the CSF simultaneously flows at different rates at two different locations of the CSF circuit.

5. The system as defined by claim 1 wherein the CSF circuit is configured to access one or more CSF-containing compartments within patient anatomy, including one or more lateral ventricles, a lumbar thecal sac, a third ventricle, a fourth ventricle, and a cisterna magna.

6. The system as defined by claim 1 wherein the CSF rate is greater than the therapeutic rate.

7. The system as defined by claim 1 wherein the two points on the body comprise ports that permit access to an interior of a patient.

8. The system as defined by claim 1 wherein the catheter comprises a flow sensor, a pressure sensor, or both the flow sensor and the pressure sensor.

9. The system as defined by claim 8 wherein the catheter comprises a catheter controller in communication with the pump, the catheter controller being configured to track and limit use of the catheter.

10. The system as defined by claim 1 wherein the therapeutic inlet comprises a syringe or a fluid bag.

11. The system as defined by claim 1 further comprising a sample port in fluid communication with the catheter.

Assignments (1)

Continuity (3)

References Cited (343)