Collagen scaffolds
View Patent ↗Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally, methods and related kits for the repair of articular tissue using the collagen material are provided.
1. A collagen implant configured to repair tissue exposed to synovial fluid, the collagen implant comprising:
an implant body having a size and shape that is configured for implantation into an articular joint where synovial fluid is present, the implant body entirely comprised of a self-assembly of collagen fibers, the self-assembly of collagen fibers having calcium, and including less than about 50,000 ng/g of DNA, less than about 5,000 uM/g of phospholipids, less than about 2,000 ug/g of GAG, less than about 25 ug/g of nucleic acids, wherein the collagen fibers are Type I collagen, and wherein the implant body is expandable and compressible and is capable of absorbing at least 3 ml of blood and has resistance to degradation by synovial fluid.
2. The collagen scaffold implant of claim 1 , wherein the Type I collagen is obtained from a bovine knee.
3. The collagen implant of claim 1 , wherein the self-assembly of collagen fibers comprises atelocollagen.
4. The collagen implant of claim 1 , wherein the self-assembly of collagen fibers further comprises a therapeutic protein.
5. The collagen implant of claim 1 , wherein the implant body has a first end, a second end opposed to the first end, and an outer wall that forms a generally cylindrical shape.
6. The collagen implant of claim 1 , wherein the implant is capable of absorbing at least 9 ml of blood.
7. The collagen implant of claim 1 , wherein the implant body is configured to permit a suture to pass therethrough.
8. The collagen implant of claim 1 , wherein the self-assembly of collagen fibers are substantially free of one or more of the following components: thrombin, non-autologous cellular components, active pepsin, and active virus.
9. The collagen implant of claim 7 , wherein the implant body is configured to be indirectly coupled to an anchor via the suture.
10. The collagen implant of claim 1 , wherein the collagen implant is a sponge.
11. The collagen implant of claim 1 , wherein the implant body is 22 mm in diameter.
12. The collagen implant of claim 1 , wherein the implant body is 30 mm in length.
13. The collagen implant of claim 1 , wherein the self-assembly of collagen fibers include greater than 100 ug/g of GAG.
14. The collagen implant of claim 1 , wherein the self-assembly of collagen fibers have a collagen concentration of greater than 10 mg/mL.