Bakuchiol compositions for treatment of post inflammatory hyperpigmentation
View Patent ↗Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.
1. A method for neutralizing reactive oxygen species and protecting melanocytes from oxidative stress under inflammation conditions in a deep layer of skin, the method comprising administering to a mammal an effective amount of a composition comprising bakuchiol, or a pharmaceutically acceptable salt thereof, at least one preservative, and a pharmaceutically acceptable carrier and less than 500 ppm total furanocoumarin impurities.
2. The method of claim 1 , wherein the preservative comprises phenoxyethanol, chlorphenesin, or a combination thereof.
3. The method of claim 1 , wherein the at least one anti-inflammatory, anti-microbial, biocide agent, or combination thereof comprises α-hydroxyacids, salicylic acid, p-linoleic acid, retinoids, benzoyl peroxide, sodium sulfacetamide, clindamycin, erythromycin, dapsone, tetracycline, doxycyclin, minocyclin, zinc, estrogen and its derivatives, chlorphenesin, anti-androgens, sulfur, corticosteroids, cortisone, tazarotene, curcumin extract, acacia extract, scutellaria extract, green tea extract, grape seed extract, or a combination thereof.
4. A composition for neutralizing reactive oxygen species and protecting melanocytes from oxidative stress under inflammation conditions in a deep layer of skin comprising bakuchiol, or a pharmaceutically acceptable salt thereof, at least one preservative, and a pharmaceutically acceptable carrier and less than 500 ppm total furanocoumarin impurities.
5. The composition of claim 4 , wherein the preservative comprises phenoxyethanol, chlorphenesin, or a combination thereof.
6. The composition of claim 4 , wherein at least one anti-inflammatory, anti-microbial, biocide agent, or combination thereof comprises α-hydroxyacids, salicylic acid, linoleic acid, retinoids, benzoyl peroxide, sodium sulfacetamide, clindamycin, erythromycin, dapsone, tetracycline, doxycyclin, minocyclin, zinc, estrogen and its derivatives, chlorphenesin, anti-androgens, sulfur, corticosteroids, cortisone, tazarotene, curcumin extract, acacia extract, scutellaria extract, green tea extract, grape seed extract, or a combination thereof.
7. A method for neutralizing reactive oxygen species and protecting melanocytes from oxidative stress under inflammation conditions in a deep layer of skin, the method comprising administering to a mammal an effective amount of a composition comprising bakuchiol, or a pharmaceutically acceptable salt thereof, at least one anti-inflammatory, anti-microbial, biocide agent, or combination thereof, and a pharmaceutically acceptable carrier and less than 500 ppm total furanocoumarin impurities.
8. A composition for neutralizing reactive oxygen species and protecting melanocytes from oxidative stress under inflammation conditions in a deep layer of skin comprising bakuchiol, or a pharmaceutically acceptable salt thereof, at least one anti-inflammatory, anti-microbial, biocide agent, or combination thereof, and a pharmaceutically acceptable carrier and less than 500 ppm total furanocoumarin impurities.