IP Library › Granted Patent US 12,478,800
Granted Patent B2
US 12,478,800 · App. 17/812,343 · Granted Nov 25, 2025

Customizable radioactive carriers and loading system

Inventors: Peter Nakaji (Phoenix, AZ); David Brachman (Phoenix, AZ); Heyoung McBride (Phoenix, AZ); Emad Youssef (Peoria, AZ); Theresa Thomas (Gilbert, AZ)
Assignee: GT MEDICAL TECHNOLOGIES, INC.
A61N5/1014A61N5/1007A61N5/1027A61N5/103A61N2005/1009A61N2005/101A61N2005/1023A61N2005/1024
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Quick Facts
Patent No.
US 12,478,800
App. No.
17/812,343
Granted
Nov 25, 2025
Kind
B2
Abstract

Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.

Claims (35)

1 . A treatment apparatus configured for at least partial placement in a surgically-created cavity of a mammal, the treatment apparatus comprising:

a plurality of rectangular flaps that are planar and each includes an antipodal surface and an opposing treatment surface, wherein the plurality of flaps include at least:

a distal flap coupled to a first side of one or more central flaps of the treatment apparatus; and

a proximal flap coupled to a second side of the one or more central flaps of the treatment apparatus; and

a plurality of radioactive seeds embedded in respective flaps;

wherein the treatment apparatus is flexible and is configured for flexing to a non-planar state wherein the proximal flap is adjacent to the distal flap, the plurality of rectangular flaps defining an interior of the treatment apparatus while in the non-planar state, wherein the antipodal surfaces of the flaps face toward the interior of the treatment apparatus in the non-planar state and the treatment surfaces of the flaps face away from the interior of the treatment apparatus toward at least some tissue of the surgically-created cavity in the non-planar state; and

wherein the treatment apparatus is configured to emit radioactive energy from the seeds to at least some mammalian tissue of the cavity through the treatment surfaces;

wherein a thickness of the plurality of flaps between the treatment surface and the antipodal surface is between 2 millimeters and 7 millimeters;

wherein the radioactive seeds are positioned closer to the antipodal surface of the plurality of flaps than to the treatment surface of the plurality of the flaps, or are positioned closer to the treatment surface of the plurality of flaps than to the antipodal surface of the plurality of the flaps.

2 . The treatment apparatus of claim 1 , wherein the one or more central flaps of the treatment apparatus includes at least two central flaps.

3 . The treatment apparatus of claim 1 , wherein the non-planar state of the treatment apparatus comprises at least a partial polyhedron having a plurality of planar faces.

4 . The treatment apparatus of claim 1 , further comprising a peripheral flap, wherein the peripheral flap comprises a first end at least partially coupled to one or more of the plurality of flaps and a second end opposite the first end.

5 . The treatment apparatus of claim 4 , wherein the peripheral flap is configured to flex toward the interior of the treatment apparatus while in the non-planar state.

6 . The treatment apparatus of claim 4 , further comprising a radioactive seed embedded in the peripheral flap.

7 . The treatment apparatus of claim 1 , further comprising one or more marking identifiers indicating a location of the radioactive seeds embedded in the plurality of flaps.

8 . The treatment apparatus of claim 1 , further comprising a plurality of perforations between adjacent flaps to further enable flexing of the treatment apparatus.

9 . The treatment apparatus of claim 1 , wherein a thickness of the plurality of flaps between the treatment surface and the antipodal surface is between 2 millimeters and 5 millimeters.

10 . The treatment apparatus of claim 1 , further comprising:

a therapeutic agent on at least the treatment surface of the plurality of flaps.

11 . The treatment apparatus of claim 10 , wherein the therapeutic agent comprises one or more of gamma particles, beta particles, alpha particles, chemotherapy agent, tumoricidal agent, viral vector agent, or immunotherapeutic agent.

12 . The treatment apparatus of claim 1 , further comprising:

a radiation shielding material.

13 . A treatment apparatus configured for at least partial placement in a cavity of a mammal, the treatment apparatus comprising:

a plurality of rectangular flaps; and

a radioactive seed embedded in each of the plurality of flaps;

wherein the treatment apparatus is flexible and is configured for flexing in a manner that a first flap of the plurality of flaps at a proximal end of the treatment apparatus is configured to be adjacent to a second flap of the plurality of flaps at a distal end of the treatment apparatus in a manner that a treatment surface of the plurality of flaps is exposed on an outer surface of an at least partially closed polyhedron formed by the flexed treatment apparatus, the treatment apparatus configured to emit radioactive energy from the radioactive seeds to at least some mammalian tissue forming the cavity;

wherein a thickness of the plurality of flaps is between 2 millimeters and 7 millimeters;

wherein the radioactive seeds are positioned closer to an antipodal surface of the plurality of flaps than to the treatment surface of the plurality of flaps, or are positioned closer to the treatment surface of the plurality of flaps than to the antipodal surface of the plurality of flaps.

14 . The treatment apparatus of claim 13 further comprising one or more central flaps positioned between the first flap and the second flap.

15 . The treatment apparatus of claim 13 , wherein the least partially closed polyhedron formed by the flexed treatment apparatus comprises a plurality of planar faces.

16 . The treatment apparatus of claim 13 further comprising a plurality of perforations to facilitate flexing of the treatment apparatus.

17 . The treatment apparatus of claim 13 , wherein a thickness of the flaps is between 1 millimeter-2 millimeters and 5 millimeters.

18 . The treatment apparatus of claim 13 , further comprising one or more markings indicating one or more locations of the radioactive seeds embedded in the plurality of flaps.

19 . The treatment apparatus of claim 13 , further comprising a peripheral flap, wherein the peripheral flap comprises a first end at least partially coupled to one or more of the plurality of flaps and a second end opposite the first end.

20 . The treatment apparatus of claim 19 , further comprising a radioactive seed embedded in the peripheral flap.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2025
From: GAMMATILE, LLC
To: GT MEDICAL TECHNOLOGIES, INC.
Reel/Frame 072706/0953 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2022
From: NAKAJI, PETER; BRACHMAN, DAVID; MCBRIDE, HEYOUNG; YOUSSEF, EMAD; THOMAS, THERESA
To: GAMMATILE LLC
Reel/Frame 061248/0475 →
Continuity (9)
Continuation 16508781 · Jul 11, 2019
Continuation 15383724 · Dec 19, 2016
Continuation In Part 15227294 · Aug 3, 2016
Continuation In Part 14703244 · May 4, 2015
Continuation 14605272 · Jan 26, 2015
Continuation 13460792 · Apr 30, 2012
Continuation 13460809 · Apr 30, 2012
Provisional Application 61480304 · Apr 28, 2011
Related Publication 20230012418A1 · Jan 12, 2023
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