IP Library › Granted Patent US 12,350,480
Granted Patent B2
US 12,350,480 · App. 17/813,702 · Granted Jul 8, 2025

Autoinjector apparatus

Inventors: Michael Denzer (Ringoes, NJ); Robert W. Swift (Fillmore, CA); Neal Johnston (Dallas, TX); Gabriele Ganzitti (Milan, IT); Kenneth R. Ewing (Fremont, CA); Suhas Krishna (Simi Valley, CA)
Assignee: AMGEN INC.
A61M5/3204A61J1/065A61M5/20A61M5/50A61M2005/206A61M2005/208A61M2005/2407A61M2005/2496A61M2005/3247A61M5/326A61M5/3271A61M2205/0216A61M2205/121A61M2205/123A61M2205/14A61M2205/502A61M2205/581A61M2205/583A61M2205/586A61M2205/6018A61M2205/6036A61M2205/6045A61M2205/8206
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Quick Facts
Patent No.
US 12,350,480
App. No.
17/813,702
Granted
Jul 8, 2025
Kind
B2
Abstract

An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement.

Claims (31)

1. A cassette for use with an autoinjector, the cassette comprising:

a syringe containing a therapeutic product and comprising an injection needle, the syringe concealed within the cassette before and after a use thereof;

an inner sleeve, the syringe disposed within the inner sleeve;

an outer housing, the inner sleeve disposed within the outer housing; and

a pin disposed on the outer housing and being configured to facilitate insertion of the cassette into a door of the autoinjector in a correct orientation.

2. The cassette of claim 1 , syringe concealed within the outer housing before and after a use thereof.

3. The cassette of claim 2 , further comprising indicia for facilitating insertion of the cassette into the door in a correct orientation.

4. The cassette of claim 2 , further comprising opposing windows defined in the outer housing that align with windows of the autoinjector when the cassette is installed therein.

5. The cassette of claim 4 , wherein the inner sleeve of the cassette further comprises a fill volume indicia viewable through the opposing windows.

6. The cassette of claim 1 , wherein the syringe is configured for single use.

7. The cassette of claim 1 , wherein the syringe further includes a needle shield and the cassette further includes a shield remover configured to pass through an end wall of the cassette, the inner sleeve configured to engage with an insertion drive to facilitate use in the autoinjector.

8. The cassette of claim 1 , wherein the inner sleeve is configured to slidably hold the syringe in the cassette and a lock cap for closing the syringe in the inner sleeve.

9. The cassette of claim 8 , further comprising a cover configured to close a distal end of the cassette and provide tamper resistance.

10. The cassette of claim 1 , wherein the pin is configured to prevent insertion of the cassette in a wrong direction.

11. A cassette for use with an autoinjector, the cassette comprising:

a syringe containing a therapeutic product, the syringe concealed within the cassette before and after a use thereof;

an inner sleeve, the syringe disposed within the inner sleeve;

an outer housing, the inner sleeve disposed within the outer housing; and

a pin disposed on the outer housing and being configured to facilitate insertion of the cassette into a door of the autoinjector in a correct orientation, further comprising a hard stop that limits travel of the syringe within the cassette, thereby ensuring needle penetration depth to a desired predetermined specification.

12. A cassette for use with an autoinjector, the cassette comprising:

an outer housing;

a syringe containing a therapeutic product and comprising an injection needle, the syringe concealed within the outer housing of the cassette before and after a use thereof;

a pin disposed on the outer housing that facilitates insertion of the cassette into a door of the autoinjector in a correct orientation; and

an indicia, including an arrow, for facilitating insertion of the cassette into a door in a correct orientation.

13. The cassette of claim 12 , further comprising opposing windows defined in the outer housing that align with windows of the autoinjector when the cassette is installed therein.

14. The cassette of claim 13 , further comprising an inner sleeve including a fill volume indicia, wherein the fill volume indicia is viewable through the opposing windows of the autoinjector.

15. The cassette of claim 12 , further comprising a hard stop that limits travel of the syringe within the cassette, thereby ensuring needle penetration depth to a desired predetermined specification.

16. The cassette of claim 12 , wherein the syringe further includes a needle shield and the cassette further includes a shield remover configured to pass through an end wall of the cassette, an inner sleeve configured to engage with an insertion drive to facilitate use in an autoinjector.

17. The cassette of claim 12 , further comprising an inner sleeve to slidably hold the syringe in the cassette and a lock cap for closing the syringe in the inner sleeve.

18. The cassette of claim 17 , further comprising a cover configured to close a distal end of the cassette and provide tamper resistance.

19. The cassette of claim 12 , wherein the arrow is offset from a surface of the outer housing.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2022
From: DENZER, MICHAEL; SWIFT, ROBERT W.; KRISHNA, SUHAS
To: AMGEN INC.
Reel/Frame 060565/0978 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2022
From: JOHNSTON, NEAL; GANZITTI, GABRIELE; EWING, KENNETH R.
To: FLEXTRONICS MEDICAL SALES AND MARKETING, LTD.
Reel/Frame 060566/0075 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2022
From: FLEXTRONICS MEDICAL SALES AND MARKETING, LTD.
To: AMGEN INC.
Reel/Frame 060566/0166 →
Continuity (5)
Continuation 16810414 · Mar 5, 2020
Continuation 16026294 · Jul 3, 2018
Continuation 14112479
Provisional Application 61477553 · Apr 20, 2011
Related Publication 20220347396A1 · Nov 3, 2022
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