Occlusion device
Provided herein is an occlusion device for intrasaccular implantation and/or vascular occlusion comprising: (a) a substantially solid marker having a proximal end, and a distal end; and (b) a low profile resilient mesh body attached to the distal end of the marker, the body having a delivery shape and a deployed shape capable of conforming to aneurysm walls; wherein the body has a diameter greater than a diameter of an aneurysm to be treated. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device disclosed herein are also disclosed.
1. An occlusion device for intrasaccular implantation in an aneurysm comprising
(a) a solid marker having a proximal end and a distal end; and
(b) a resilient mesh body attached to the distal end of the solid marker, the resilient mesh body having a delivery shape and a low profile deployed shape having a height that is between 10% to 20% of a width of the resilient mesh body in free air, and capable of conforming to vessel walls;
wherein the resilient mesh body is a dual layer of mesh comprising a single layer of mesh folded circumferentially onto itself to create a circumferential fold line around a circumference of the resilient mesh body,
wherein all ends of the dual layer of mesh intersect with the solid marker positioned at a core of said dual layer of mesh, and
wherein, in the low profile deployed shape, the resilient mesh body lays is configured to lay flush in a flattened manner against walls of the aneurysm.
2. The device of claim 1 , wherein the low profile deployed shape of the resilient mesh body is capable of apposing a dome of the aneurysm.
3. The device of claim 1 , wherein the proximal end of the solid marker is capable of sealing an aneurysm neck.
4. The device of claim 1 , wherein the solid marker is a radiopaque marker.
5. The device of claim 1 , wherein the solid marker is a detachment junction to deploy the device.
6. The device of claim 1 , wherein the solid marker is an attachment junction to retrieve the device.
7. The device of claim 1 , wherein the solid marker comprises a rigid member.
8. The device of claim 1 , wherein the solid marker is a solid ring.
9. The device of claim 1 , wherein the resilient mesh body has a height that is between about 12-18% of the width.
10. The device of claim 1 , wherein the resilient mesh body has a height that is between about 14-16% of the width.
11. The device of claim 1 , wherein the resilient mesh body has a height that is about 15% of the width.
12. The device of claim 1 wherein the resilient mesh body covers about 60% of an inner surface area of a dome of the aneurysm to be treated.
13. A kit for treatment and/or amelioration of an aneurysm, the kit comprising:
an occlusion device comprising:
(i) a solid marker having a proximal end and a distal end; and
(ii) a resilient mesh body attached to the distal end of the solid marker, the resilient mesh body having a delivery shape and a low profile deployed shape having a height that is between 10% to 20% of a width of the resilient mesh body in free air, and capable of conforming to vessel walls;
wherein the resilient mesh body is a dual layer of mesh comprising a single layer of mesh folded circumferentially onto itself to create a circumferential fold line around a circumference of the resilient mesh body,
wherein all ends of the dual layer of mesh intersect with the solid marker positioned at a core of said dual layer of mesh, and
wherein, in the low profile deployed shape, the resilient mesh body is configured to lay flush in a flattened manner against walls of the aneurysm; and
b. a delivery system corresponding to the occlusion device, wherein the delivery system is configured to deploy the occlusion device in the aneurysm.
14. The kit of claim 13 , wherein the delivery system comprises at least one device selected from a group consisting of: a microcatheter, a catheter, a guide wire, and a pusher wire.
15. The kit of claim 13 , wherein the delivery system comprises a detachment system, wherein the detachment system is an electrolytic detachment system.
16. The kit of claim 15 , wherein the solid marker is a detachment junction to deploy the device.
17. The kit of claim 13 , wherein the low profile deployed shape of the resilient mesh body is capable of apposing a dome of the aneurysm.
18. The kit of claim 13 , wherein the proximal end of the solid marker is capable of sealing an aneurysm neck.
19. The kit of claim 13 , wherein the solid marker is a radiopaque marker.
20. The device of claim 13 , wherein the solid marker is an attachment junction to retrieve the device.