IP Library › Granted Patent US 12,263,269
Granted Patent B2
US 12,263,269 · App. 17/877,485 · Granted Apr 1, 2025

Particle-form hybrid-scale fiber matrix

Inventors: Matthew R. MacEwan (St. Louis, MO); Lily Jeng (St. Louis, MO); Abdolrasol Rahimi (St. Louis, MO); Manisha Jassal (St. Louis, MO); Tamas Kovacs (St. Louis, MO)
Assignee: Acera Surgical, Inc.
A61L26/0052A61L26/008A61L2400/06A61L2430/34
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Quick Facts
Patent No.
US 12,263,269
App. No.
17/877,485
Granted
Apr 1, 2025
Kind
B2
Abstract

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

Claims (18)

1. A plurality of particles configured to improve wound healing, the plurality of particles comprising:

an average diameter of less than 5000 μm;

wherein the plurality of particles are formed by breaking down a sheet of electrospun graft material, wherein the electrospun graft material possesses a hybrid-scale fiber structure and

wherein the plurality of particles include the hybrid-scale fiber structure of the electrospun graft material.

2. The plurality of particles of claim 1 , wherein plurality of particles are mixed with other fibers or nonfibrous structures.

3. The plurality of particles of claim 1 , wherein the sheet of electrospun graft material comprises a plurality of electrospun fibers, the plurality of electrospun fibers formed by electrospinning a first fiber composition and a second fiber composition, the first fiber composition comprising poly(lactic-co-glycolic acid), and the second fiber composition comprising polydioxanone.

4. The plurality of particles of claim 1 , wherein the sheet of electrospun graft material comprises a plurality of electrospun fibers, the plurality of electrospun fibers formed by electrospinning a first fiber composition and a second fiber composition, the first fiber composition different from the second fiber composition.

5. The plurality of particles of claim 4 ,

wherein the first fiber composition comprises a polymer selected from one or more of: polycaprolactone (poly(ε-caprolactone), PCL), polydioxanone (PDO), poly(glycolic acid) (PGA), poly(L-lactic acid) (PLA), poly(lactide-co-glycolide) (PLGA), poly(L-lactide) (PLLA), poly(D,L-lactide) (P(DLLA)), poly(ethylene glycol) (PEG), montmorillonite (MMT), poly(L-lactide-co-ε-caprolactone) (P(LLA-CL)), poly(ε-caprolactone-co-ethyl ethylene phosphate) (P(CL-EEP)), poly[bis(p-methylphenoxy)phosphazene] (PNmPh), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), poly(ester urethane)urea (PEUU), poly(p-dioxanone) (PPDO), polyurethane (PU), polyethylene terephthalate (PET), poly(ethylene-co-vinylacetate) (PEVA), poly(ethylene oxide) (PEO), poly(phosphazene), poly(ethylene-co-vinyl alcohol), polymer nanoclay nanocomposites, poly(ethylenimine), poly(ethyleneoxide), poly vinylpyrrolidone; polystyrene (PS) and combinations thereof, and;

wherein the second fiber composition comprises a polymer selected from one or more of: polycaprolactone (poly(ε-caprolactone), PCL), polydioxanone (PDO), poly(glycolic acid) (PGA), poly(L-lactic acid) (PLA), poly(lactide-co-glycolide) (PLGA), poly(L-lactide) (PLLA), poly(D,L-lactide) (P(DLLA)), poly(ethylene glycol) (PEG), montmorillonite (MMT), poly(L-lactide-co-εcaprolactone) (P(LLA-CL)), poly(ε-caprolactone-co-ethyl ethylene phosphate) (P(CL-EEP)), poly[bis(p-methylphenoxy)phosphazene] (PNmPh), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), poly(ester urethane)urea (PEUU), poly(p-dioxanone) (PPDO), polyurethane (PU), polyethylene terephthalate (PET), poly(ethylene-co-vinylacetate) (PEVA), poly(ethylene oxide) (PEO), poly(phosphazene), poly(ethylene-co-vinyl alcohol), polymer nanoclay nanocomposites, poly(ethylenimine), poly(ethyleneoxide), poly vinylpyrrolidone; polystyrene (PS) and combinations thereof.

6. The plurality of particles of claim 1 , wherein the plurality of particles are configured to be mixed with fluid to create an injectable solution.

7. The plurality of particles of claim 1 , wherein the plurality of particles are sorted based on physical or mechanical properties.

8. The plurality of particles of claim 1 , wherein the plurality of particles are sorted based on one or more of: surface area, mass, size, shape, density, pourability, deployability, flowability, charge, viscosity, color, or reflectivity.

9. The plurality of particles of claim 1 , wherein the particles are configured to be placed directly onto a wound site.

10. The plurality of particles of claim 1 , wherein the particles are incorporated into a hydrogel.

11. The plurality of particles of claim 4 , wherein the ratio of the first fiber composition to the second fiber composition can range from about 1:10 to about 10:1.

12. The plurality of particles of claim 1 , wherein the particles are further combined with one or more of: bone marrow aspirate, platelet rich plasma, other powders, other polymers, drugs, cells, growth factors, radioactive agents, chemical agents, or bioactive agents.

13. The plurality of particles of claim 11 , wherein the plurality of particles are configured to be applied to a suture line.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 12, 2026
From: ACERA SURGICAL, INC.
To: SOLVENTUM INTELLECTUAL PROPERTIES COMPANY
Reel/Frame 074933/0515 →
RELEASE OF SECURITY INTEREST Recorded Dec 23, 2025
From: WILSON FAMILY LEGACY TRUST NO. I
To: ACERA SURGICAL, INC.
Reel/Frame 073303/0131 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 25, 2025
From: MACEWAN, MATTHEW R.; JENG, LILY; RAHIMI, ABDOLRASOL; JASSAL, MANISHA; KOVACS, TAMAS
To: ACERA SURGICAL, INC.
Reel/Frame 070326/0231 →
SECURITY INTEREST Recorded Mar 26, 2023
From: ACERA SURGICAL, INC.
To: WILSON FAMILY LEGACY TRUST NO. 1
Reel/Frame 063103/0303 →
Continuity (2)
Provisional Application 63203737 · Jul 29, 2021
Related Publication 20230033599A1 · Feb 2, 2023
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