Soft cassette with integrated features
A soft cassette includes a body including a flexible material and first and second component. The body defines first and second lumens and first and second chambers. The first lumen extends between first and second ends. The first chamber is in the first lumen such that fluid passing through the first lumen passes through the first chamber. The second lumen is fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber. The second chamber is in the second lumen. The first component is on a first side of the second chamber and includes a first ferromagnetic metal or magnet. The second component is on a second side of the second chamber and includes a second ferromagnetic metal magnet.
1 . A soft cassette comprising:
a body comprising a flexible material, the body defining,
a first lumen extending between a first end and a second end,
a first chamber in the first lumen such that fluid passing through the first lumen passes through the first chamber,
a second lumen fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber, and
a second chamber in the second lumen;
a first cover cooperating with the body to define a first pocket;
a second cover cooperating with the body to define a second pocket;
a first component on a first side of the second chamber and in the first pocket, the first component comprising a first ferromagnetic metal or a first magnet; and
a second component on a second side of the second chamber and in the second pocket, the second component comprising a second ferromagnetic metal or a second magnet.
2 . The soft cassette of claim 1 , wherein
the body includes a first side and a second side,
the first side and the second side cooperate to define the first lumen, the first chamber, the second lumen, and the second chamber.
3 . The soft cassette of claim 2 , wherein
the body defines a first center plane between the first side and the second side, and
the first chamber is reflection asymmetric about the first center plane.
4 . The soft cassette of claim 3 , wherein the first chamber is reflection asymmetric about a second center plane perpendicular to the first center plane.
5 . The soft cassette of claim 1 , wherein
the body defines an orthogonal coordinate system including a first axis, a second axis, and a third axis,
a center of the first chamber is offset from a center of the second chamber along the first axis and the second axis.
6 . The soft cassette of claim 1 , wherein the body further defines a first valve path in the first lumen or the second lumen, the first valve path defining a circular cross section.
7 . The soft cassette of claim 6 , wherein
the body defines a first region and a second region, the second region including the first valve path
the first region defines a first thickness,
the second region defines a second thickness adjacent to the first valve path, the second thickness being less than the first thickness.
8 . The soft cassette of claim 6 , wherein the body further defines a plurality of valve paths including,
the first valve path between a first end of the first chamber and a first end of the second lumen,
a second valve path between a second end of the first chamber and a second end of the second lumen, and
a third valve path between the first end of the second lumen and the second chamber.
9 . The soft cassette of claim 1 , further comprising:
a filter in the first chamber.
10 . The soft cassette of claim 9 , further comprising:
a first port fluidly connected to the first end of the first lumen; and
a second port fluidly connected to the second end of the first lumen.
11 . The soft cassette of claim 10 , wherein the first port and the second port define distinct shapes, colors, or both shapes and colors.
12 . The soft cassette of claim 11 , wherein only one of the first port and the second port defines a radially-extending flange.
13 . The soft cassette of claim 1 , further comprising:
a first tube in the first lumen between the first end and the first chamber, and
a second tube in the first lumen between the second end and the first chamber.
14 . The soft cassette of claim 1 , wherein
a region between the first side of the second chamber and the second side of the second chamber is unobstructed, and
at least one of the first side of the second chamber and the second side of the second chamber is configured to move between a first state and a second state based on a pressure in the second chamber.
15 . The soft cassette of claim 14 , wherein
in the first state, the second chamber defines a first pressure and a first dimension is defined between the first component and the second component,
in the second state, the second chamber defines a second pressure and a second dimension is defined between the first component and the second component,
the second pressure is larger than the first pressure, and
the second dimension is larger than the first dimension.
16 . A soft cassette assembly comprising:
a base plate defining a plurality of receiving regions;
a door attached to the base plate;
a first magnet coupled to the base plate;
a second magnet coupled to the door;
a pressure sensor in contact with the first magnet or the second magnet; and
a soft cassette configured to be attached to the base plate, the soft cassette including,
a body defining,
a first lumen extending between a first end and a second end,
a first chamber in the first lumen such that fluid passing through the first lumen passes through the first chamber,
a second lumen fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber, and
a second chamber in the second lumen;
a first component on a first side of the second chamber, the first component comprising a first ferromagnetic metal, the first component being configured to be coupled to the first magnet; and
a second component on a second side of the second chamber, the second component comprising a second ferromagnetic material, the second component being configured to be coupled to the second magnet.
17 . A method of manufacturing a soft cassette, the method comprising:
forming a first side of a soft cassette body from a first thermoplastic sheet portion;
forming a second side of the soft cassette body from a second thermoplastic sheet portion;
fixing the first side to the second side to at least partially define a first lumen extending between a first end and a second end, a first chamber in the first lumen, a second lumen fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber, and a second chamber in the second lumen; and
creating the soft cassette by sealing a perimeter of the first side and the second side.
18 . The method of claim 17 , further comprising:
coupling a first component to the first side, the first component including a first ferromagnetic metal or a first magnet.
19 . The method of claim 18 , wherein the coupling includes,
disposing the first component between the first side and a cover, and
fixing the cover to the first side to define a pocket, the first component being in the pocket.
20 . The method of claim 19 , wherein the fixing includes radiofrequency welding the cover to the first side around a periphery of the cover.
21 . The method of claim 18 , further comprising:
coupling a second component to the second side, the second component including a second ferromagnetic metal or a second magnet.
22 . The method of claim 17 , wherein the forming the first side and the forming the second side are performed concurrently.
23 . The method of claim 17 , wherein the forming the first side, the forming the second side, the fixing, and the creating are performed using radio frequency energy.
24 . The method of claim 17 , wherein
the forming the first side includes forming a first valve region, the first valve region having a smaller thickness than a first body region of the first side,
the forming the second side includes forming a second valve region, the second valve region having a smaller thickness than a second body region of the second side, and
the fixing further includes at least partially defining a valve path between at least a portion of the first valve region and at least a portion of the second valve region.
25 . The method of claim 24 , further comprising:
prior to the fixing, disposing a cylindrical mandrel between the first valve region and the second valve region,
after the fixing, removing the cylindrical mandrel such that the valve path is between the first valve region and the second valve region and the valve path defines a circular cross section.
26 . The method of claim 17 , further comprising:
prior to the fixing, disposing a distinct component at least partially between the first side and the second side, the distinct component including a filter, a tube, a port, a pump, or any combination thereof, wherein the fixing secures the distinct component between the first side and the second side.
27 . The method of claim 26 , further comprising:
prior to the fixing, folding a sheet including the first side and the second side such that the first side is in direct contact with the second side.
28 . A soft cassette comprising:
a body comprising a flexible material, the body defining,
a first lumen extending between a first end and a second end,
a first chamber in the first lumen such that fluid passing through the first lumen passes through the first chamber,
a second lumen fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber, and
a second chamber in the second lumen;
a first component on a first side of the second chamber, the first component comprising a first ferromagnetic metal or a first magnet; and
a second component on a second side of the second chamber, the second component comprising a second ferromagnetic metal or a second magnet,
wherein a region between the first side of the second chamber and the second side of the second chamber is unobstructed,
at least one of the first side of the second chamber and the second side of the second chamber is configured to move between a first state and a second state based on a pressure in the second chamber,
in the first state, the second chamber defines a first pressure and a first dimension is defined between the first component and the second component,
in the second state, the second chamber defines a second pressure and a second dimension is defined between the first component and the second component,
the second pressure is larger than the first pressure, and
the second dimension is larger than the first dimension.