IP Library › Granted Patent US 12,735,497
Granted Patent B2
US 12,735,497 · App. 18/132,486 · Granted Sep 15, 2026

Bispecific anti-human a-beta/human transferrin receptor antibodies and methods of use

Inventors: Harald Duerr (Starnberg, DE); Sebastian Fenn (Achmuehle/Eurasburg, DE); Ulrich Goepfert (Penzberg, DE); Sabine Imhof-Jung (Planegg, DE); Christian Klein (Bonstetten, CH); Laurent Lariviere (Munich, DE); Michael Molhoj (Munich, DE); Joerg Thomas Regula (Munich, DE); Petra Rueger (Penzberg, DE); Wolfgang Schaefer (Mannheim, DE)
Assignee: HOFFMANN-LA ROCHE INC.
C07K16/2881A61P25/28C07K16/18C07K16/468A61K2039/505C07K2317/31C07K2317/51C07K2317/515C07K2317/52C07K2317/522C07K2317/55C07K2317/56C07K2317/64
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Quick Facts
Patent No.
US 12,735,497
App. No.
18/132,486
Granted
Sep 15, 2026
Kind
B2
Abstract

Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.

Claims (24)

1 . One or more nucleic acids encoding a bispecific antibody specifically binding to human A-beta protein and human transferrin receptor, wherein the bispecific antibody comprises:

(i) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 01;

(ii) a second polypeptide comprising the amino acid sequence of SEQ ID NO: 02;

(iii) a third polypeptide comprising the amino acid sequence of SEQ ID NO: 03; and

(iv) a fourth polypeptide comprising the amino acid sequence of SEQ ID NO: 10.

2 . A host cell, comprising the one or more nucleic acids of claim 1 .

3 . The host cell of claim 2 , wherein the host cell is a Chinese hamster ovary (CHO) cell.

4 . An expression vector, comprising the one or more nucleic acids of claim 1 .

5 . A host cell, comprising the expression vector of claim 4 .

6 . The host cell of claim 5 , wherein the host cell is a CHO cell.

7 . A method of producing a bispecific antibody specifically binding to human A-beta protein and human transferrin receptor, comprising:

(i) culturing a host cell comprising one or more nucleic acids encoding the bispecific antibody, wherein the host cell is cultured under conditions suitable for the expression of the bispecific antibody, and wherein the bispecific antibody comprises a first polypeptide comprising the amino acid sequence of SEQ ID NO: 01, a second polypeptide comprising the amino acid sequence of SEQ ID NO: 02, a third polypeptide comprising the amino acid sequence of SEQ ID NO: 03, and a fourth polypeptide comprising the amino acid sequence of SEQ ID NO: 10; and

(ii) recovering the bispecific antibody from the host cell or from the host cell culture medium.

8 . A pharmaceutical formulation, comprising the bispecific antibody expressed from the one or more nucleic acids of claim 1 and a pharmaceutically acceptable carrier.

9 . The method of claim 7 , wherein the host cell is a CHO cell.

10 . A bispecific antibody specifically binding to human A-beta protein and human transferrin receptor produced by the method of claim 7 .

11 . A pharmaceutical formulation, comprising the bispecific antibody of claim 10 and a pharmaceutically acceptable carrier.

12 . The host cell of claim 2 , wherein the host cell is an HEK293 cell.

13 . The host cell of claim 5 , wherein the host cell is an HEK293 cell.

14 . The method of claim 7 , wherein the host cell is an HEK293 cell.

15 . The one or more nucleic acids of claim 1 , wherein the one or more nucleic acids are in a single vector.

16 . The one or more nucleic acids of claim 1 , wherein the one or more nucleic acids are in separate vectors.

17 . The method of claim 7 , wherein the one or more nucleic acids are in a single vector.

18 . The method of claim 7 , wherein the one or more nucleic acids are in separate vectors.

Priority Claims (1)
EP 15188064 · Oct 2, 2015 · regional
Continuity (4)
Continuation 17130477 · Dec 22, 2020
Continuation 15941655 · Mar 30, 2018
Continuation PCTEP2016073411 · Sep 30, 2016
Related Publication 20230365702A1 · Nov 16, 2023
References Cited (400)
US 3773919A · Boswell et al. · 1973 [cited by applicant]
US 4120649A · Schechter et al. · 1978 [cited by applicant]
US 4665077A · Stringfellow et al. · 1987 [cited by applicant]
US 4666829A · Glenner et al. · 1987 [cited by applicant]
US 4737456A · Weng et al. · 1988 [cited by applicant]
US 4816567A · Cabilly et al. · 1989 [cited by applicant]
US 4861579A · Meyer, Jr. et al. · 1989 [cited by applicant]
US 4892538A · Aebischer et al. · 1990 [cited by applicant]
US 5114721A · Cohen et al. · 1992 [cited by applicant]
US 5154924A · Friden · 1992 [cited by applicant]
US 5195317A · Nobue et al. · 1993 [cited by applicant]
US 5208020A · Chari et al. · 1993 [cited by applicant]
US 5231000A · Majocha et al. · 1993 [cited by applicant]
US 5283187A · Aebischer et al. · 1994 [cited by applicant]
US 5416064A · Chari et al. · 1995 [cited by applicant]
US 5427927A · Meyer et al. · 1995 [cited by applicant]
US 5500362A · Robinson et al. · 1996 [cited by applicant]
US 5595721A · Kaminski et al. · 1997 [cited by applicant]
US 5624821A · Winter et al. · 1997 [cited by applicant]
US 5635483A · Pettit et al. · 1997 [cited by applicant]
US 5648237A · Carter et al. · 1997 [cited by applicant]
US 5648260A · Winter et al. · 1997 [cited by applicant]
US 5677180A · Robinson et al. · 1997 [cited by applicant]
US 5688651A · Solomon et al. · 1997 [cited by applicant]
US 5712374A · Kunstmann et al. · 1998 [cited by applicant]
US 5714586A · Kunstmann et al. · 1998 [cited by applicant]
US 5721108A · Robinson et al. · 1998 [cited by applicant]
US 5736137A · Anderson et al. · 1998 [cited by applicant]
US 5739116A · Hamann et al. · 1998 [cited by applicant]
US 5767285A · Hamann et al. · 1998 [cited by applicant]
US 5770429A · Lonberg et al. · 1998 [cited by applicant]
US 5770701A · McGahren et al. · 1998 [cited by applicant]
US 5770710A · McGahren et al. · 1998 [cited by applicant]
US 5773001A · Hamann et al. · 1998 [cited by applicant]
US 5776456A · Anderson et al. · 1998 [cited by applicant]
US 5780588A · Pettit et al. · 1998 [cited by applicant]
US 5789199A · Joly et al. · 1998 [cited by applicant]
US 5821337A · Carter et al. · 1998 [cited by applicant]
US 5840523A · Simmons et al. · 1998 [cited by applicant]
US 5843398A · Kaminski et al. · 1998 [cited by applicant]
US 5843439A · Anderson et al. · 1998 [cited by applicant]
US 5849898A · Seed et al. · 1998 [cited by applicant]
US 5877296A · Hamann et al. · 1999 [cited by applicant]
US 5955317A · Suzuki et al. · 1999 [cited by applicant]
US 5959177A · Hein et al. · 1999 [cited by applicant]
US 6008326A · Loosmore et al. · 1999 [cited by applicant]
US 6015542A · Kaminski et al. · 2000 [cited by applicant]
US 6015555A · Friden · 2000 [cited by applicant]
US 6040498A · Stomp et al. · 2000 [cited by applicant]
US 6066652A · Zenner et al. · 2000 [cited by applicant]
US 6075181A · Kucherlapati et al. · 2000 [cited by applicant]
US 6083747A · Wong et al. · 2000 [cited by applicant]
US 6090365A · Kaminski et al. · 2000 [cited by applicant]
US 6120767A · Robinson et al. · 2000 [cited by applicant]
US 6150584A · Kucherlapati et al. · 2000 [cited by applicant]
US 6171586B1 · Lam et al. · 2001 [cited by applicant]
US 6194551B1 · Idusogie et al. · 2001 [cited by applicant]
US 6224866B1 · Barbera-Guillem · 2001 [cited by applicant]
US 6242195B1 · Idusogie et al. · 2001 [cited by applicant]
US 6267958B1 · Andya et al. · 2001 [cited by applicant]
US 6287537B1 · Kaminski et al. · 2001 [cited by applicant]
US 6306393B1 · Goldenberg et al. · 2001 [cited by applicant]
US 6368596B1 · Ghetie et al. · 2002 [cited by applicant]
US 6399061B1 · Anderson et al. · 2002 [cited by applicant]
US 6410391B1 · Zelsacher · 2002 [cited by applicant]
US 6417429B1 · Hein et al. · 2002 [cited by applicant]
US 6420548B1 · Vezina et al. · 2002 [cited by applicant]
US 6455043B1 · Grillo-Lopez · 2002 [cited by applicant]
US 6528624B1 · Idusogie et al. · 2003 [cited by applicant]
US 6538124B1 · Idusogie et al. · 2003 [cited by applicant]
US 6565827B1 · Kaminski et al. · 2003 [cited by applicant]
US 6602684B1 · Umana et al. · 2003 [cited by applicant]
US 6630579B2 · Chari et al. · 2003 [cited by applicant]
US 6652852B1 · Robinson et al. · 2003 [cited by applicant]
US 6682734B1 · Anderso · 2004 [cited by applicant]
US 6737056B1 · Presta et al. · 2004 [cited by applicant]
US 6982321B2 · Winter et al. · 2006 [cited by applicant]
US 7041870B2 · Tomizuka et al. · 2006 [cited by applicant]
US 7087409B2 · Barbas et al. · 2006 [cited by applicant]
US 7125978B1 · Vezina et al. · 2006 [cited by applicant]
US 7189826B2 · Rodman · 2007 [cited by applicant]
US 7332581B2 · Presta et al. · 2008 [cited by applicant]
US 7371826B2 · Presta et al. · 2008 [cited by applicant]
US 7498298B2 · Doronina et al. · 2009 [cited by applicant]
US 7521541B2 · Eigenbrot et al. · 2009 [cited by applicant]
US 7527791B2 · Adams et al. · 2009 [cited by applicant]
US 7687061B2 · Hanai et al. · 2010 [cited by applicant]
US 7794719B2 · Bardroff et al. · 2010 [cited by applicant]
US 8187594B2 · Mather et al. · 2012 [cited by applicant]
US 8216577B2 · Bardroff et al. · 2012 [cited by applicant]
US 8313913B2 · Nakamura et al. · 2012 [cited by applicant]
US 8329886B2 · Bardroff et al. · 2012 [cited by applicant]
US 8883980B2 · Umana et al. · 2014 [cited by applicant]
US 8906370B2 · Loetscher et al. · 2014 [cited by applicant]
US 8945867B2 · Ogawa et al. · 2015 [cited by applicant]
US 9272031B2 · Loetscher et al. · 2016 [cited by applicant]
US 9598496B2 · Kurosawa et al. · 2017 [cited by applicant]
US 9708406B2 · Zhang et al. · 2017 [cited by applicant]
US 9714292B2 · Auer et al. · 2017 [cited by applicant]
US 10323089B2 · Dengl et al. · 2019 [cited by applicant]
US 10323099B2 · Bruenker et al. · 2019 [cited by applicant]
US 10364292B2 · Rueger et al. · 2019 [cited by applicant]
US 10370692B2 · Kopetzki et al. · 2019 [cited by applicant]
US 10808036B2 · Zhang et al. · 2020 [cited by applicant]
US 10941205B2 · Duerr et al. · 2021 [cited by applicant]
US 11098338B2 · Kopetzki et al. · 2021 [cited by applicant]
US 11584793B2 · Dengl et al. · 2023 [cited by applicant]
US 11603411B2 · Duerr et al. · 2023 [cited by applicant]
US 11787868B2 · Duerr et al. · 2023 [cited by applicant]
US 12030952B2 · Duerr et al. · 2024 [cited by applicant]
US 12252533B2 · Dengl et al. · 2025 [cited by applicant]
US 12358997B1 · Duerr et al. · 2025 [cited by applicant]
US 20010018041A1 · Hanna et al. · 2001 [cited by applicant]
US 20010056066A1 · Bugelski et al. · 2001 [cited by applicant]
US 20020004587A1 · Miller et al. · 2002 [cited by applicant]
US 20020006404A1 · Hanna et al. · 2002 [cited by applicant]
US 20020009427A1 · Wolin et al. · 2002 [cited by applicant]
US 20020009444A1 · Grillo-Lopez et al. · 2002 [cited by applicant]
US 20020012665A1 · Hanna et al. · 2002 [cited by applicant]
US 20020025313A1 · Micklus et al. · 2002 [cited by applicant]
US 20020041847A1 · Goldenberg · 2002 [cited by applicant]
US 20020058029A1 · Hanna et al. · 2002 [cited by applicant]
US 20020127652A1 · Schambye et al. · 2002 [cited by applicant]
US 20020128488A1 · Yamakawa et al. · 2002 [cited by applicant]
US 20020136719A1 · Shenoy et al. · 2002 [cited by applicant]
US 20020164328A1 · Shinkawa et al. · 2002 [cited by applicant]
US 20020197255A1 · Anderson et al. · 2002 [cited by applicant]
US 20020197256A1 · Grewal et al. · 2002 [cited by applicant]
US 20030003097A1 · Reff et al. · 2003 [cited by applicant]
US 20030021781A1 · Anderson et al. · 2003 [cited by applicant]
US 20030026801A1 · Weiner et al. · 2003 [cited by applicant]
US 20030082172A1 · Anderson et al. · 2003 [cited by applicant]
US 20030095963A1 · Anderson et al. · 2003 [cited by applicant]
US 20030103971A1 · Hariharan et al. · 2003 [cited by applicant]
US 20030115614A1 · Kanda et al. · 2003 [cited by applicant]
US 20030133930A1 · Goldenberg et al. · 2003 [cited by applicant]
US 20030147885A1 · Anderson et al. · 2003 [cited by applicant]
US 20030148404A1 · Michaelson · 2003 [cited by applicant]
US 20030157108A1 · Presta et al. · 2003 [cited by applicant]
US 20030180292A1 · Hanna et al. · 2003 [cited by applicant]
US 20030185796A1 · Wolin et al. · 2003 [cited by applicant]
US 20030202972A1 · Andya et al. · 2003 [cited by applicant]
US 20030219433A1 · Hansen et al. · 2003 [cited by applicant]
US 20030219818A1 · Bohen et al. · 2003 [cited by applicant]
US 20040082762A1 · Basi et al. · 2004 [cited by applicant]
US 20040093621A1 · Shitara et al. · 2004 [cited by applicant]
US 20040109865A1 · Niwa et al. · 2004 [cited by applicant]
US 20040110282A1 · Kanda et al. · 2004 [cited by applicant]
US 20040110704A1 · Yamane et al. · 2004 [cited by applicant]
US 20040131692A1 · Kreuter et al. · 2004 [cited by applicant]
US 20040132140A1 · Satoh et al. · 2004 [cited by applicant]
US 20040180417A1 · Seidah et al. · 2004 [cited by applicant]
US 20040192898A1 · Jia et al. · 2004 [cited by applicant]
US 20040197324A1 · Liu et al. · 2004 [cited by applicant]
US 20040204354A1 · Nelson et al. · 2004 [cited by applicant]
US 20040248197A1 · Holtzman et al. · 2004 [cited by applicant]
US 20050014934A1 · Hinton et al. · 2005 [cited by applicant]
US 20050031613A1 · Nakamura et al. · 2005 [cited by applicant]
US 20050058644A1 · Engelman · 2005 [cited by applicant]
US 20050123546A1 · Umana et al. · 2005 [cited by applicant]
US 20050142133A1 · Lazar et al. · 2005 [cited by applicant]
US 20050147613A1 · Raso · 2005 [cited by applicant]
US 20050169925A1 · Bardroff et al. · 2005 [cited by applicant]
US 20050180972A1 · Wahl et al. · 2005 [cited by applicant]
US 20050260186A1 · Bookbinder et al. · 2005 [cited by applicant]
US 20060008883A1 · Lazar et al. · 2006 [cited by applicant]
US 20060104968A1 · Bookbinder et al. · 2006 [cited by applicant]
US 20060210557A1 · Luisi et al. · 2006 [cited by applicant]
US 20060251652A1 · Watkins et al. · 2006 [cited by applicant]
US 20070061900A1 · Murphy et al. · 2007 [cited by applicant]
US 20070098721A1 · Heinz et al. · 2007 [cited by applicant]
US 20070134759A1 · Nishiya et al. · 2007 [cited by applicant]
US 20080167449A1 · Lazar et al. · 2008 [cited by applicant]
US 20080241884A1 · Shitara et al. · 2008 [cited by applicant]
US 20080275220A1 · Friess et al. · 2008 [cited by applicant]
US 20090162359A1 · Klein et al. · 2009 [cited by applicant]
US 20090252724A1 · Loetscher et al. · 2009 [cited by applicant]
US 20090263491A1 · Kreuter et al. · 2009 [cited by applicant]
US 20090297436A1 · Garcia-Martinez et al. · 2009 [cited by applicant]
US 20090297439A1 · Comoglio et al. · 2009 [cited by applicant]
US 20100016786A1 · Drews et al. · 2010 [cited by applicant]
US 20100077498A1 · Pardridge et al. · 2010 [cited by applicant]
US 20100081796A1 · Brinkmann et al. · 2010 [cited by applicant]
US 20100098693A1 · Pardridge et al. · 2010 [cited by applicant]
US 20100121036A1 · Fischer et al. · 2010 [cited by applicant]
US 20100129357A1 · Garcia-Martinez et al. · 2010 [cited by applicant]
US 20100172907A1 · Bardroff et al. · 2010 [cited by applicant]
US 20100190247A1 · Lazar et al. · 2010 [cited by applicant]
US 20100256338A1 · Brinkmann et al. · 2010 [cited by applicant]
US 20100290985A1 · Pardridge et al. · 2010 [cited by applicant]
US 20100322934A1 · Imhof-Jung et al. · 2010 [cited by applicant]
US 20110070225A1 · Goldbach et al. · 2011 [cited by applicant]
US 20120034160A1 · Ghayur et al. · 2012 [cited by applicant]
US 20120141484A1 · Garcia-Martinez et al. · 2012 [cited by applicant]
US 20120171120A1 · Dennis et al. · 2012 [cited by applicant]
US 20120244577A1 · Dixit et al. · 2012 [cited by applicant]
US 20130034554A1 · Garcia-Martinez et al. · 2013 [cited by applicant]
US 20130039925A1 · Bansal · 2013 [cited by applicant]
US 20130045206A1 · Poul et al. · 2013 [cited by applicant]
US 20130078249A1 · Ast et al. · 2013 [cited by applicant]
US 20130090457A1 · Cunningham et al. · 2013 [cited by applicant]
US 20130136747A1 · Bardroff et al. · 2013 [cited by applicant]
US 20130177579A1 · Lin et al. · 2013 [cited by applicant]
US 20130315901A1 · Derosier et al. · 2013 [cited by applicant]
US 20140114054A1 · Kurosawa et al. · 2014 [cited by applicant]
US 20140154254A1 · Kannan et al. · 2014 [cited by applicant]
US 20140212423A1 · Karaoglu-Hanzatian et al. · 2014 [cited by applicant]
US 20140271459A1 · Dutzar · 2014 [cited by applicant]
US 20140271464A1 · Garcia-Martinez et al. · 2014 [cited by applicant]
US 20140271661A1 · Ye et al. · 2014 [cited by applicant]
US 20150030589A1 · Goldbach et al. · 2015 [cited by applicant]
US 20150110791A1 · Zhang et al. · 2015 [cited by applicant]
US 20150125446A1 · Klein et al. · 2015 [cited by applicant]
US 20150132217A1 · Chang et al. · 2015 [cited by applicant]
US 20150140003A1 · Klauza et al. · 2015 [cited by applicant]
US 20150196663A1 · Shusta et al. · 2015 [cited by applicant]
US 20150266947A1 · Sierks · 2015 [cited by applicant]
US 20150315296A1 · Schaefer et al. · 2015 [cited by applicant]
US 20150322149A1 · Bohrmann et al. · 2015 [cited by applicant]
US 20150353639A1 · Watts et al. · 2015 [cited by applicant]
US 20160145348A1 · Stephan · 2016 [cited by applicant]
US 20180171012A1 · Sonoda et al. · 2018 [cited by applicant]
US 20180222992A1 · Duerr et al. · 2018 [cited by applicant]
US 20180222993A1 · Duerr et al. · 2018 [cited by applicant]
US 20180282408A1 · Dengl et al. · 2018 [cited by applicant]
US 20180291110A1 · Klein et al. · 2018 [cited by applicant]
US 20190276530A1 · Bohrmann et al. · 2019 [cited by applicant]
US 20200055931A1 · Dengl et al. · 2020 [cited by applicant]
US 20200071413A1 · Rueger et al. · 2020 [cited by applicant]
US 20200216553A1 · Seeber et al. · 2020 [cited by applicant]
US 20200216554A1 · Duerr et al. · 2020 [cited by applicant]
US 20210087288A1 · Zhang et al. · 2021 [cited by applicant]
US 20210301030A1 · Duerr et al. · 2021 [cited by applicant]
US 20220144963A9 · Duerr et al. · 2022 [cited by applicant]
US 20220306761A1 · Durerr et al. · 2022 [cited by applicant]
US 20230220071A1 · Dengl et al. · 2023 [cited by applicant]
US 20240317879A1 · Duerr et al. · 2024 [cited by applicant]
US 20240417451A1 · Abrantes et al. · 2024 [cited by applicant]
US 20250154249A1 · Dengl et al. · 2025 [cited by applicant]
US 20250163173A1 · Rueger et al. · 2025 [cited by applicant]
US 20250223372A1 · Duerr et al. · 2025 [cited by applicant]
US 20250297025A1 · Duerr et al. · 2025 [cited by applicant]
CN 101245107A · 2008 [cited by applicant]
EP 0332865A2 · 1989 [cited by applicant]
EP 0307434B1 · 1993 [cited by applicant]
EP 0683234A1 · 1994 [cited by applicant]
EP 0425235B1 · 1996 [cited by applicant]
EP 0330191B1 · 1996 [cited by applicant]
EP 0340109B1 · 1997 [cited by applicant]
EP 1125905A1 · 2001 [cited by applicant]
EP 2343086A1 · 2011 [cited by applicant]
EP 2668901A1 · 2013 [cited by applicant]
EP 2708560A1 · 2014 [cited by applicant]
EP 2787078A1 · 2014 [cited by applicant]
EP 3315606A1 · 2018 [cited by applicant]
JP 2015528452A · 2015 [cited by applicant]
JP 2017187722A · 2017 [cited by applicant]
RU 2439160C1 · 2012 [cited by applicant]
WO WO9008187A1 · 1990 [cited by applicant]
WO WO9011294A1 · 1990 [cited by applicant]
WO WO91001133A1 · 1991 [cited by applicant]
WO 9103259A1 · 1991 [cited by applicant]
WO WO9310819A1 · 1993 [cited by applicant]
WO WO9321232A1 · 1993 [cited by applicant]
WO WO9325673A1 · 1993 [cited by applicant]
WO WO9411026A2 · 1994 [cited by applicant]
WO WO9429351A2 · 1994 [cited by applicant]
WO WO9503770A1 · 1995 [cited by applicant]
WO WO95015769A1 · 1995 [cited by applicant]
WO WO9607321A1 · 1996 [cited by applicant]
WO WO96020218A1 · 1996 [cited by applicant]
WO WO96025088A1 · 1996 [cited by applicant]
WO WO9639628A1 · 1996 [cited by applicant]
WO WO9704801A1 · 1997 [cited by applicant]
WO WO97008320A1 · 1997 [cited by applicant]
WO WO9730087A1 · 1997 [cited by applicant]
WO WO9856418A1 · 1998 [cited by applicant]
WO WO9858964A1 · 1998 [cited by applicant]
WO WO9922764A1 · 1999 [cited by applicant]
WO WO9927944A1 · 1999 [cited by applicant]
WO WO99051642A1 · 1999 [cited by applicant]
WO WO0009160A1 · 2000 [cited by applicant]
WO WO0023472A2 · 2000 [cited by applicant]
WO WO0027428A1 · 2000 [cited by applicant]
WO WO0027433A1 · 2000 [cited by applicant]
WO WO0042072A2 · 2000 [cited by applicant]
WO WO0044788A1 · 2000 [cited by applicant]
WO WO0061739A1 · 2000 [cited by applicant]
WO WO0061768A1 · 2000 [cited by applicant]
WO WO0064482A1 · 2000 [cited by applicant]
WO WO0067795A1 · 2000 [cited by applicant]
WO WO0067796A1 · 2000 [cited by applicant]
WO WO0072880A1 · 2000 [cited by applicant]
WO WO0074718A1 · 2000 [cited by applicant]
WO WO0076542A1 · 2000 [cited by applicant]
WO WO0077178A1 · 2000 [cited by applicant]
WO WO0103734A1 · 2001 [cited by applicant]
WO WO0110460A1 · 2001 [cited by applicant]
WO WO0110461A1 · 2001 [cited by applicant]
WO WO0110462A1 · 2001 [cited by applicant]
WO WO0113945A1 · 2001 [cited by applicant]
WO WO0129246A1 · 2001 [cited by applicant]
WO WO0134194A1 · 2001 [cited by applicant]
WO WO0139796A1 · 2001 [cited by applicant]
WO WO0162801A2 · 2001 [cited by applicant]
WO WO0177342A1 · 2001 [cited by applicant]
WO WO0197858A2 · 2001 [cited by applicant]
WO WO0202597A2 · 2002 [cited by applicant]
WO WO0204021A1 · 2002 [cited by applicant]
WO WO02031140A1 · 2002 [cited by applicant]
WO WO0234790A1 · 2002 [cited by applicant]
WO WO02046237A2 · 2002 [cited by applicant]
WO WO02060955A2 · 2002 [cited by applicant]
WO WO02064734A2 · 2002 [cited by applicant]
WO WO02088306A2 · 2002 [cited by applicant]
WO WO02088307A2 · 2002 [cited by applicant]
WO WO02096937A2 · 2002 [cited by applicant]
WO WO02096948A2 · 2002 [cited by applicant]
WO WO03002607A1 · 2003 [cited by applicant]
WO WO03009817A2 · 2003 [cited by applicant]
WO WO03011878A2 · 2003 [cited by applicant]
WO WO03016466A2 · 2003 [cited by applicant]
WO WO03061694A1 · 2003 [cited by applicant]
WO WO03068821A2 · 2003 [cited by applicant]
WO WO03070760A2 · 2003 [cited by applicant]
WO WO03084570A1 · 2003 [cited by applicant]
WO WO03085107A1 · 2003 [cited by applicant]
WO WO03085119A1 · 2003 [cited by applicant]
WO WO2004014953A2 · 2004 [cited by applicant]
WO 2004020404A2 · 2004 [cited by applicant]
WO WO2004020454A2 · 2004 [cited by applicant]
WO WO2004032868A2 · 2004 [cited by applicant]
WO WO2004035607A2 · 2004 [cited by applicant]
WO WO2004056312A2 · 2004 [cited by applicant]
WO WO2004069870A2 · 2004 [cited by applicant]
WO WO2005035586A1 · 2005 [cited by applicant]
WO WO2005035778A1 · 2005 [cited by applicant]
WO WO2005053742A1 · 2005 [cited by applicant]
WO WO2005092925A2 · 2005 [cited by applicant]
WO WO2005100402A1 · 2005 [cited by applicant]
WO WO2005116220A1 · 2005 [cited by applicant]
WO 2006030220A1 · 2006 [cited by applicant]
WO WO2006029879A2 · 2006 [cited by applicant]
WO WO2006044908A2 · 2006 [cited by applicant]
WO WO2006083689A2 · 2006 [cited by applicant]
WO WO2006131013A2 · 2006 [cited by applicant]
WO WO2007044323A2 · 2007 [cited by applicant]
WO WO2007059782A1 · 2007 [cited by applicant]
WO WO2007068429A1 · 2007 [cited by applicant]
WO WO2007110339A1 · 2007 [cited by applicant]
WO 2007143711A2 · 2007 [cited by applicant]
WO WO2008005847A2 · 2008 [cited by applicant]
WO WO2008022349A2 · 2008 [cited by applicant]
WO WO2008025527A1 · 2008 [cited by applicant]
WO WO2008039944A2 · 2008 [cited by applicant]
WO WO2008063771A2 · 2008 [cited by applicant]
WO WO2008071394A1 · 2008 [cited by applicant]
WO WO2008077546A1 · 2008 [cited by applicant]
WO WO2009018411A1 · 2009 [cited by applicant]
WO WO2009040562A1 · 2009 [cited by applicant]
WO WO2009126616A2 · 2009 [cited by applicant]
WO WO2010033587A2 · 2010 [cited by applicant]
WO WO2010102251A2 · 2010 [cited by applicant]
WO WO2010115551A1 · 2010 [cited by applicant]
WO WO2010115553A1 · 2010 [cited by applicant]
WO WO2011066369A2 · 2011 [cited by applicant]
WO WO2011066371A2 · 2011 [cited by applicant]
WO WO2011116387A1 · 2011 [cited by applicant]
WO WO2011130377A2 · 2011 [cited by applicant]
WO 2012088247A2 · 2012 [cited by applicant]
WO WO2012075037A1 · 2012 [cited by applicant]
WO WO2012087835A2 · 2012 [cited by applicant]
WO WO2012093125A1 · 2012 [cited by applicant]
WO WO2012096924A1 · 2012 [cited by applicant]
WO WO2012130831A1 · 2012 [cited by applicant]
WO WO2012143379A1 · 2012 [cited by applicant]
WO 2013006244A1 · 2013 [cited by applicant]
WO WO2013012733A1 · 2013 [cited by applicant]
WO WO2013025853A1 · 2013 [cited by applicant]
WO WO2013026831A1 · 2013 [cited by applicant]
WO WO2013038156A1 · 2013 [cited by applicant]
WO WO2013039471A1 · 2013 [cited by applicant]
WO WO2013079174A1 · 2013 [cited by applicant]
WO WO2013113615A1 · 2013 [cited by applicant]
WO WO2013127816A1 · 2013 [cited by applicant]
WO WO2013177062A2 · 2013 [cited by applicant]
WO WO2014033074A1 · 2014 [cited by applicant]
WO WO2014039855A1 · 2014 [cited by applicant]
WO WO2014047231A1 · 2014 [cited by applicant]
WO WO2014052188A1 · 2014 [cited by applicant]
WO WO2014081955A1 · 2014 [cited by applicant]
WO WO2014082179A1 · 2014 [cited by applicant]
WO WO2014131694A1 · 2014 [cited by applicant]
WO WO2014131711A1 · 2014 [cited by applicant]
WO WO2014183973A1 · 2014 [cited by applicant]
WO WO2014189973A2 · 2014 [cited by applicant]
WO WO2015014884A1 · 2015 [cited by applicant]
WO WO2015063339A1 · 2015 [cited by applicant]
WO WO2015091144A1 · 2015 [cited by applicant]
WO WO2015095392A1 · 2015 [cited by applicant]