IP Library › Granted Patent US 12,358,997
Granted Patent B1
US 12,358,997 · App. 19/093,136 · Granted Jul 15, 2025

Bispecific anti-human A-beta/anti-human transferrin receptor antibodies

Inventors: Harald Duerr (Starnberg, DE); Sebastian Fenn (Achmuehle/Eurasburg, DE); Ulrich Goepfert (Penzberg, DE); Sabine Imhof-Jung (Planegg, DE); Christian Klein (Bonstetten, CH); Laurent Lariviere (Munich, DE); Michael Molhoj (Munich, DE); Joerg Thomas Regula (Munich, DE); Petra Rueger (Penzberg, DE); Wolfgang Schaefer (Mannheim, DE)
Assignee: HOFFMANN-LA ROCHE INC.
C07K16/2881A61P25/28C07K16/18C07K16/468A61K2039/505C07K2317/31C07K2317/51C07K2317/515C07K2317/52C07K2317/522C07K2317/55C07K2317/56C07K2317/64
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Quick Facts
Patent No.
US 12,358,997
App. No.
19/093,136
Granted
Jul 15, 2025
Kind
B1
Abstract

Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.

Claims (6)

1. A bispecific antibody comprising:

a) a full length antibody, wherein the full length antibody comprises a first full length antibody light chain and a first full length antibody heavy chain, and a second full length antibody light chain and a second full length antibody heavy chain, wherein the first full length antibody heavy chain and the first full length antibody light chain form a binding site that specifically binds to a first antigen, wherein the second full length antibody heavy chain and the second full length antibody light chain form a binding site that specifically binds to the first antigen; and

b) a Fab fragment, wherein the Fab fragment comprises a Fab heavy chain and a Fab light chain having a domain crossover such that the constant light chain domain (CL) and the constant heavy chain domain 1 (CH1) are replaced by each other, wherein the Fab heavy chain is fused to the C-terminus of the second full length antibody heavy chain to form a polypeptide, wherein the Fab heavy chain and the Fab light chain form a binding site that specifically binds to a second antigen;

wherein the first antigen is human A-beta protein, and the second antigen is human transferrin receptor; and

wherein the first full length antibody light chain and the second full length antibody light chain each comprises the amino acid sequence of SEQ ID NO: 01, the first full length antibody heavy chain comprises the amino acid sequence of SEQ ID NO: 02, the Fab light chain comprises the amino acid sequence of SEQ ID NO: 03, and the polypeptide comprising the Fab heavy chain fused to the second full length antibody heavy chain comprises the amino acid sequence of SEQ ID NO: 10.

2. A pharmaceutical formulation, comprising the bispecific antibody of claim 1 and a pharmaceutically acceptable carrier.

Priority Claims (1)
EP 15188064 · Oct 2, 2015 · regional
Continuity (4)
Continuation 18132486 · Apr 10, 2023
Continuation 17130477 · Dec 22, 2020
Division 15941655 · Mar 30, 2018
Continuation PCTEP2016073411 · Sep 30, 2016
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