Granted Patent
B2
US 12,076,306 · App. 18/144,890 · Granted Sep 3, 2024
Prodrugs of fumarates and their use in treating various diseases
Inventors:
Tarek A. Zeidan (Lexington, MA); Scott Duncan (Bedford, MA); Christopher P. Hencken (Boston, MA); Thomas Andrew Wynn (Lexington, MA); Carlos N. Sanrame (Lexington, MA)
Assignee:
Alkermes Pharma Ireland Limited
A61K31/225C07C219/08C07C229/16C07C233/18C07C233/91C07C235/88C07C317/18C07C317/28C07D207/06C07D207/40C07D209/52C07D211/06C07D211/38C07D295/088C07D491/113
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Abstract
The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
Claims (5)
1. A compound having the formula
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
3. A method of treating multiple sclerosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .
4. A method of treating multiple sclerosis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the composition of claim 2 .
Assignments (3)
SECURITY INTEREST
Recorded Feb 13, 2026
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 074858/0405 →
RELEASE OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (073213/0302)
Recorded Feb 13, 2026
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 074858/0429 →
SECURITY INTEREST
Recorded Oct 23, 2025
From: ALKERMES PHARMA IRELAND LIMITED
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 073213/0302 →
Continuity (10)
Provisional Application
61934365
· Jan 31, 2014
Provisional Application
61782445
· Mar 14, 2013