Granted Patent
B2
US 12,599,497 · App. 18/151,816 · Granted Apr 14, 2026
Implants with controlled drug delivery features and methods of using same
Inventors:
David S. Haffner (Mission Viejo, CA); Thomas W. Burns (Dana Point, CA); Harold A. Heitzmann (Irvine, CA); Kenneth M. Curry (Oceanside, CA)
Assignee:
Glaukos Corporation
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Claims (29)
1 . A method of treating an ocular disorder, comprising:
inserting an implant into an eye, the implant comprising:
an outer shell defining an interior space, the outer shell having a proximal end and a closed distal end;
a permeable or semi-permeable membrane positioned within the interior space of the outer shell;
at least one fluid inflow pathway and at least one fluid outflow pathway positioned adjacent the closed distal end of the outer shell; and
a retention protrusion extending from the closed distal end;
anchoring the retention protrusion of the implant to an intraocular tissue in an anterior chamber of an eye;
eluting one or more drugs through the permeable or semi-permeable membrane, wherein the permeable or semi-permeable membrane at least partially controls a rate of elution, and
permitting drainage of ocular fluid from the anterior chamber to a physiological outflow space through the at least one fluid inflow pathway and the at least one fluid outflow pathway.
2 . The method of claim 1 , wherein the physiological outflow space is Schlemm's canal.
3 . The method of claim 1 , wherein anchoring the retention protrusion to the intraocular tissue further comprises positioned the retention protrusion such that it extends into but not through the intraocular tissue.
4 . The method of claim 1 , further comprising eluting the one or more drugs through at least one orifice of a cap.
5 . The method of claim 1 , wherein the retention protrusion comprises ridges, claws, threads, flexible ribs, rivet-like shape, flexible barbs, sharpened tip or barbed tip.
6 . The method of claim 1 , wherein the implant is inserted using an applicator comprising a handpiece having an elongate tip connected to a distal end of the handpiece.
7 . The method of claim 6 , wherein inserting the implant further comprises using an actuator disposed on the handpiece to release the implant from a holder positioned at the distal end of the elongate tip.
8 . A method of treating an ocular disorder, comprising:
inserting an implant into an eye, the implant comprising:
an outer shell defining an interior space containing at least one drug, the outer shell having a proximal end and a closed distal end;
a membrane positioned within the interior space of the outer shell; and
at least one fluid inflow pathway and at least one fluid outflow pathway positioned adjacent the closed distal end of the outer shell;
anchoring the implant to an intraocular tissue in an anterior chamber of an eye;
eluting one or more drugs through the membrane, wherein the membrane at least partially controls a rate of elution; and
delivering an ocular fluid from the anterior chamber to a physiological outflow space through the at least one fluid inflow pathway and the at least one fluid outflow pathway.
9 . The method of claim 8 , wherein the physiological outflow space is Schlemm's canal.
10 . The method of claim 8 , wherein the implant is anchored to the intraocular tissue using a retention protrusion.
11 . The method of claim 10 , wherein anchoring the retention protrusion to the intraocular tissue further comprises positioning the retention protrusion such that it extends into but not through the intraocular tissue.
12 . The method of claim 10 , wherein the retention protrusion comprises ridges, claws, threads, flexible ribs, rivet-like shape, flexible barbs, sharpened tip or barbed tip.
13 . The method of claim 8 , wherein the implant is inserted using an applicator comprising a handpiece having an elongate tip connected to a distal end of the handpiece.
14 . The method of claim 13 , wherein inserting the implant further comprises using an actuator disposed on the handpiece to release the implant from a holder positioned at the distal end of the elongate tip.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 30, 2025
From: DOSE MEDICAL CORPORATION
To: GLAUKOS CORPORATION
Reel/Frame 070066/0322 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 29, 2025
From: HAFFNER, DAVID S.; BURNS, THOMAS W.; HEITZMANN, HAROLD A.; CURRY, KENNETH M.
To: DOSE MEDICAL CORPORATION
Reel/Frame 070051/0827 →
Continuity (5)
Continuation
14776666
Provisional Application
61788731
· Mar 15, 2013
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