IP Library › Granted Patent US 12,649,984
Granted Patent B2
US 12,649,984 · App. 18/219,246 · Granted Jun 9, 2026

Time-dependent synthetic biological barrier material

Inventors: Michael Scott Taylor (Anderson, SC); Seth Dylan McCullen (Greenville, SC); David Shalaby (Southfield, MA)
Assignee: POLY-MED, INC.
D04H1/728A61F2/0063A61L31/06A61L31/129A61L31/14A61L31/148D04H1/43835A61F2210/0004A61L2400/12
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Quick Facts
Patent No.
US 12,649,984
App. No.
18/219,246
Granted
Jun 9, 2026
Kind
B2
Abstract

Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed to yield a stabilizing effect without altering morphological properties of a first fiber system. By addition of a stabilizing fiber population one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state. In one particular abstract, medical barrier materials may be formed from the electrospun materials to provide improved medical barriers for treatments.

Claims (23)

1 . A thermally stable electrospun barrier comprising:

a first population of fibers, the first population of fibers comprising at least one thermally unstable species;

a second population of fibers, the second population of fibers comprising at least one thermally stable species;

wherein the first population of fibers and the second population of fibers are co-mingled and distributed throughout the electrospun barrier;

wherein the first population of fibers and the second population of fibers are distinct and independent from each other;

wherein the fibers of each fiber population are not composite fibers comprising both the thermally unstable species and the thermally stable species;

wherein the electrospun barrier forms at least a portion of an implantable material;

wherein the electrospun barrier exhibits limited macroscopic changes in physical and mechanical properties when exposed to thermal or mechanical stress; and

wherein the second population of fibers is present in the thermally stable electrospun barrier in an amount of from 13 to 49% by weight.

2 . The thermally stable electrospun barrier of claim 1 , wherein the first population of fibers is absorbable.

3 . The thermally stable electrospun barrier of claim 1 , wherein the second population of fibers is absorbable.

4 . The thermally stable electrospun barrier of claim 1 , wherein porosity is 75% or greater.

5 . The thermally stable electrospun barrier of claim 1 , wherein the thermally stable electrospun barrier is dimensionally stable over a range of temperatures from 30° C. to 60° C. and will not decrease in size by more than 10 percent.

6 . The thermally stable electrospun barrier of claim 1 , wherein porosity of the thermally stable electrospun barrier increases as the first population of fibers is absorbed.

7 . The thermally stable electrospun barrier of claim 1 , wherein the first population of fibers is a bioabsorbable copolymer derived from cyclic monomers selected from the group consisting of glycolide, lactide, caprolactone, para-dioxanone, trimethylene carbonate, or mixtures thereof.

8 . The thermally stable electrospun barrier of claim 7 , wherein the first population of fibers is an absorbable copolymer of glycolide and lactide.

9 . The thermally stable electrospun barrier of claim 8 , wherein the first population of fibers is an absorbable PGLA copolymer with a monomer ratio of glycolide to lactide of about 90:10.

10 . The thermally stable electrospun barrier of claim 1 , wherein the second population of fibers is a polyether-ester.

11 . The thermally stable electrospun barrier of claim 10 , wherein the second population of fibers is a block copolymer having one or more blocks of polydioxanone.

12 . The thermally stable electrospun barrier of claim 11 , wherein polydioxanone comprises from 10% to 80% of the copolymer.

13 . The thermally stable electrospun barrier of claim 1 , wherein the second population of fibers is nonabsorbable.

14 . The thermally stable electrospun barrier of claim 13 , wherein the nonabsorbable fiber is poly(ethylene terephthalate).

15 . The thermally stable electrospun barrier of claim 13 , wherein the second population of fibers is a mixture of at least two polymers and a nonabsorbable fiber comprises from 10% to 80% of the mixture.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2023
From: TAYLOR, MICHAEL SCOTT; MCCULLEN, SETH DILLON; SHALABY, DAVID
To: POLY-MED, INC.
Reel/Frame 064658/0222 →
Continuity (3)
Continuation 15115650
Provisional Application 61933578 · Jan 30, 2014
Related Publication 20240018707A1 · Jan 18, 2024
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