IP Library › Granted Patent US 12,698,270
Granted Patent B2
US 12,698,270 · App. 18/255,247 · Granted Aug 4, 2026

Aryl ether-substituted heterocyclic compounds as GLP1R agonists

Inventors: Long Zhang (Hangzhou, CN); Zhangming Niu (Hangzhou, CN); Bowen Tang (Hangzhou, CN)
Assignee: MINDRANK AI LTD.
C07D401/14C07D405/14C07D471/04
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Quick Facts
Patent No.
US 12,698,270
App. No.
18/255,247
Filed
May 31, 2023
Granted
Aug 4, 2026
Kind
B2
Art Unit
1691
USPC
514/303
Abstract

A novel aryl ether substituted heterocyclic compound has GLP1R agonist activity. A GLP1R agonist is represented by formula (I), or a pharmaceutically acceptable salt, solvate, hydrate, isotope substituent or isomer thereof.

Claims (10)

1 . A compound, which is:

or a pharmaceutically acceptable salt, solvate, enantiomer, or isotopic variation thereof.

2 . The compound of claim 1 , which is:

or a pharmaceutically acceptable salt thereof.

3 . The compound of claim 1 , which is:

or a pharmaceutically acceptable salt.

4 . The compound of claim 1 , which is:

or a pharmaceutically acceptable salt.

5 . A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 1 .

6 . A method of treating obesity or diabetes in a subject in need thereof, comprising administering a therapeutically effective amount of the compound of claim 1 to the subject.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2023
From: ZHANG, LONG; NIU, ZHANGMING; TANG, BOWEN
To: MINDRANK AI LTD.
Reel/Frame 063811/0819 →
Priority Claims (2)
CN 202111017657.5 · Aug 30, 2021 · national
CN 202111168512.5 · Sep 29, 2021 · national
Continuity (1)
Related Publication 20240067630A1 · Feb 29, 2024
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