Granted Patent B2

US 12,268,822 · App. 18/304,228 · Granted Apr 8, 2025

Inventors: Steven M. Blair (Salt Lake City, UT); Bradley Jay Katz (Salt Lake City, UT)

Assignee: University of Utah Research Foundation

A61M21/02A61N5/0618G02B5/22G02B5/285G02C7/104A61M2021/0044A61N2005/0663A61N2005/0667G02B5/289G02B2207/101

Abstract

Claims (98)

1. An apparatus for reducing the frequency and/or severity of photophobic responses by controlling light exposure to melanopsin ganglion cells in a retina, the apparatus comprising an optical filter configured to transmit:

a first amount of light determined by a weighted average across a Gaussian function with central wavelength of about 480 nm and full-width at half-maximum of about 52 nm, the first amount of light being a dose of light experienced by the cis isoform of the melanopsin ganglion cells of a subject (D melan );

a second amount of light determined by a weighted average across a Gaussian function with central wavelength of about 590 nm and full-width at half-maximum of about 40 nm, the second amount of light being a dose of light experienced by the trans isoform of the melanopsin ganglion cells of a subject (D rec,590 ); and

a third amount of light determined by a weighted average across a Gaussian function with central wavelength of about 550 nm and full-width at half-maximum of about 134 nm, the third amount of light is a dose of light experienced over the visual response spectrum (D vis ),

wherein a ratio including the third amount of light and the first amount of light is defined as a first figure of merit (FOM 1 ), the first figure of merit being determined by:

FOM

1

=

1

-

D

m

⁢

e

⁢

l

⁢

a

⁢

n

D

m

⁢

e

⁢

l

⁢

a

⁢

n

(

T

=

1

)

1

-

D

v

⁢

i

⁢

s

D

v

⁢

i

⁢

s

(

T

=

1

)

where D melan (T=1) is the first amount of light in the absence of an optical filter, and D vis (T=1) is the third amount of light in the absence of an optical filter, wherein the first figure of merit of the optical filter is between 0.9 and 1.5, and

wherein a ratio including the third amount of light and the second amount of light is defined as a second figure of merit (FOM 2 ), the second figure of merit being determined by:

FOM

2

=

1

-

D

590

·

rec

D

590

,

rec

(

T

=

1

)

1

-

D

v

⁢

i

⁢

s

D

v

⁢

i

⁢

s

(

T

=

1

)

where D 590,rec (T=1) is the second amount of light in the absence of an optical filter,

wherein the second figure of merit of the optical filter is between 1.25 and 2.0.

2. The apparatus of claim 1 , wherein the first figure of merit FOM 1 is 1.3±0.1.

3. The apparatus of claim 1 , wherein the second figure of merit FOM 2 is 1.425±0.05.

4. The apparatus of claim 1 , wherein the optical filter has chromaticity coordinates of x=0.33±0.03 and y=0.33±0.03.

Assignments (2)

Continuity (8)

References Cited (158)