IP Library › Granted Patent US 12,655,230
Granted Patent B2
US 12,655,230 · App. 18/358,884 · Granted Jun 16, 2026

Heterodimeric antibodies that bind CD3 and GPC3

Inventors: Alex Nisthal (Monrovia, CA); Nargess Hassanzadeh-Kiabi (Monrovia, CA); Katrina Bykova (Seattle, WA); Matthew J. Bernett (Monrovia, CA); Rajat Varma (Bethesda, MD)
Assignee: Xencor, Inc.
C07K16/468A61P35/00C07K16/2809A61K2039/505C07K2317/31C07K2317/55C07K2317/565C07K2317/567C07K2317/622C07K2317/92C07K2317/94
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Quick Facts
Patent No.
US 12,655,230
App. No.
18/358,884
Granted
Jun 16, 2026
Kind
B2
Abstract

Provided herein are novel GPC3 binding domains, and antibodies that include such GPC3 binding domains (e.g., anti-GPC3×anti-CD3). Also provided herein are methods of using such antibodies for the treatment of GPC3-associated cancers.

Claims (29)

1 . A composition comprising a GPC3 antigen binding domain comprising a variable light domain and a variable heavy domain selected from the following:

a) a variable light domain having the amino acid sequence of SEQ ID NO: 237 and a variable heavy domain having the amino acid of SEQ ID NO: 181;

b) a variable light domain having the amino acid sequence of SEQ ID NO: 177 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

c) a variable light domain having the amino acid sequence of SEQ ID NO: 177 and a variable heavy domain having the amino acid sequence of SEQ ID NO: SEQ ID NO: 181;

d) a variable light domain having the amino acid sequence of SEQ ID NO: 177 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 185;

e) a variable light domain having the amino acid sequence of SEQ ID NO: 177 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 189;

f) a variable light domain having the amino acid sequence of SEQ ID NO: 177 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 193;

g) a variable light domain having the amino acid sequence of SEQ ID NO: 197 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

h) a variable light domain having the amino acid sequence of SEQ ID NO: 201 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

i) a variable light domain having the amino acid sequence of SEQ ID NO: 205 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

j) a variable light domain having the amino acid sequence of SEQ ID NO: 209 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

k) a variable light domain having the amino acid sequence of SEQ ID NO: 213 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

l) a variable light domain having the amino acid sequence of SEQ ID NO: 217 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

m) a variable light domain having the amino acid sequence of SEQ ID NO: 221 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

n) a variable light domain having the amino acid sequence of SEQ ID NO: 225 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

o) a variable light domain having the amino acid sequence of SEQ ID NO: 229 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

p) a variable light domain having the amino acid sequence of SEQ ID NO: 233 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 173;

q) a variable light domain having the amino acid sequence of SEQ ID NO: 249 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

r) a variable light domain having the amino acid sequence of SEQ ID NO: 241 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

s) a variable light domain having the amino acid sequence of SEQ ID NO: 245 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

t) a variable light domain having the amino acid sequence of SEQ ID NO: 253 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

u) a variable light domain having the amino acid sequence of SEQ ID NO: 257 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

v) a variable light domain having the amino acid sequence of SEQ ID NO: 261 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

w) a variable light domain having the amino acid sequence of SEQ ID NO: 265 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

x) a variable light domain having the amino acid sequence of SEQ ID NO: 269 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

y) a variable light domain having the amino acid sequence of SEQ ID NO: 273 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

z) a variable light domain having the amino acid sequence of SEQ ID NO: 277 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181;

a1) a variable light domain having the amino acid sequence of SEQ ID NO: 281 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181; and

a2) a variable light domain having the amino acid sequence of SEQ ID NO: 285 and a variable heavy domain having the amino acid sequence of SEQ ID NO: 181.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 31, 2023
From: NISTHAL, ALEX; HASSANZADEH-KIABI, NARGESS; BYKOVA, KATRINA; BERNETT, MATTHEW J.; VARMA, RAJAT
To: XENCOR, INC.
Reel/Frame 064766/0493 →
Continuity (4)
Continuation 17692045 · Mar 10, 2022
Provisional Application 63173127 · Apr 9, 2021
Provisional Application 63159058 · Mar 10, 2021
Related Publication 20240034815A1 · Feb 1, 2024
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