IP Library › Granted Patent US 12,534,463
Granted Patent B2
US 12,534,463 · App. 18/382,210 · Granted Jan 27, 2026

Substituted tricyclic compounds as FGFR inhibitors

Inventors: Liangxing Wu (Wilmington, DE); Colin Zhang (Berwyn, PA); Chunhong He (Boothwyn, PA); Liang Lu (Hockessin, DE); Wenqing Yao (Chadds Ford, PA)
Assignees: Incyte Corporation; Incyte Holdings Corporation
C07D471/14A61P1/16A61P11/00A61P19/02C07D471/20C07D471/22C07D491/22C07D495/14C07D498/14C07D498/22
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Quick Facts
Patent No.
US 12,534,463
App. No.
18/382,210
Granted
Jan 27, 2026
Kind
B2
Abstract

The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.

Claims (2)

1 . A method of treating achrondroplasia in a patient comprising administering to said patient a therapeutically effective amount of 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo [3′,2′: 5,6]pyrido [4,3-d]pyrimidin-2-one, or a pharmaceutically acceptable salt thereof.

2 . The method of claim 1 , wherein the method comprises administering to said patient a therapeutically effective amount of 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo [3′,2′: 5,6]pyrido [4,3-d]pyrimidin-2-one.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 18, 2025
From: INCYTE CORPORATION
To: INCYTE CORPORATION; INCYTE HOLDINGS CORPORATION
Reel/Frame 073259/0695 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 27, 2023
From: WU, LIANGXING; ZHANG, COLIN; HE, CHUNHONG; LU, LIANG; YAO, WENQING
To: INCYTE CORPORATION
Reel/Frame 065366/0784 →
Continuity (10)
Division 17337027 · Jun 2, 2021
Division 16842558 · Apr 7, 2020
Division 16152827 · Oct 5, 2018
Division 15408768 · Jan 18, 2017
Division 13915775 · Jun 12, 2013
Provisional Application 61774841 · Mar 8, 2013
Provisional Application 61740012 · Dec 20, 2012
Provisional Application 61691463 · Aug 21, 2012
Provisional Application 61659245 · Jun 13, 2012
Related Publication 20240246974A1 · Jul 25, 2024
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