IP Library › Granted Patent US 12,398,207
Granted Patent B2
US 12,398,207 · App. 18/810,362 · Granted Aug 26, 2025

Heterodimeric antibodies that bind CD3 and CLDN6

Inventors: Matthew S. Faber (Glendora, CA); Sung-Hyung Lee (San Gabriel, CA); Yoon Kyung Kim (Pomona, CA); Jing Qi (Arcadia, CA); Kendra N. Avery (Hawthorne, CA); Seung Y. Chu (Upland, CA); Alex Nisthal (Monrovia, CA); Matthew J. Bernett (Monrovia, CA); John R. Desjarlais (Pasadena, CA); Chad Borchert (Nowthen, MN)
Assignee: Xencor, Inc.
C07K16/28A61P35/00C07K16/2809C07K16/468C12N15/63
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Quick Facts
Patent No.
US 12,398,207
App. No.
18/810,362
Granted
Aug 26, 2025
Kind
B2
Abstract

Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Claims (16)

1. A bispecific antibody comprising:

a) a first monomer comprising:

i) an anti-CD3 single chain variable fragment (scFv) comprising the amino acid sequence of SEQ ID NO: 98; and

ii) a first variant human IgG1 Fc domain,

b) a second monomer comprising:

i) a variable heavy domain (VH); and

ii) a second variant human IgG1 Fc domain; and

c) a light chain comprising a variable light domain (VL),

wherein said VH and said VL form a means for binding an extracellular domain of human claudin 6 (CLDN6).

2. A bispecific antibody comprising:

a) a first monomer comprising, from N- to C-terminus, an anti-CD3 single chain variable fragment (scFv) comprising the amino acid sequence of SEQ ID NO: 98, and a first variant human IgG1 Fc domain;

b) a second monomer comprising, from N- to C-terminus, VH-CH1-hinge-second variant human IgG1 Fc domain; and

c) a light chain comprising a variable light domain (VL),

wherein said VH and said VL form a means for binding an extracellular domain of human claudin 6 (CLDN6).

3. The bispecific antibody according to claim 1 , wherein said first variant human IgG1 Fc domain comprises the amino acid substitutions T366S, L368A, and Y407V, and said second variant human IgG1 Fc domain comprises the amino acid substitution T366W, wherein numbering is according to the EU Index as in Kabat.

4. The bispecific antibody according to claim 2 , wherein said first variant human IgG1 Fc domain comprises the amino acid substitutions T366S, L368A, and Y407V, and said second variant human IgG1 Fc domain comprises the amino acid substitution T366W, wherein numbering is according to the EU Index as in Kabat.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2024
From: BORCHERT, CHAD
To: BIO-TECHNE CORPORATION
Reel/Frame 068622/0892 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2024
From: BIO-TECHNE CORPORATION
To: XENCOR, INC.
Reel/Frame 068623/0024 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2024
From: FABER, MATTHEW S.; LEE, SUNG-HYUNG; KIM, YOON KYUNG; QI, JING; AVERY, KENDRA N.; CHU, SEUNG Y.; NISTHAL, ALEX; BERNETT, MATTHEW J.; DESJARLAIS, JOHN R.
To: XENCOR, INC.
Reel/Frame 068982/0182 →
Continuity (4)
Continuation 18348244 · Jul 6, 2023
Continuation 17690702 · Mar 9, 2022
Provisional Application 63158584 · Mar 9, 2021
Related Publication 20240400675A1 · Dec 5, 2024
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