IP Library Granted Patent US 12,447,169
Granted Patent B2
US 12,447,169 · App. 18/828,652 · Granted Oct 21, 2025

Maribavir isomers, compositions, methods of making and methods of using

Inventor: John D. Peabody, III (West Chester, PA)
Assignee: Takeda Pharmaceutical Company Limited
A61K31/7056A61K45/06G01N33/94G09B19/00G01N2430/00G01N2800/52
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Quick Facts
Patent No.
US 12,447,169
App. No.
18/828,652
Granted
Oct 21, 2025
Kind
B2
Abstract

The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for counteracting the potentially adverse effects of maribavir isomerization in vivo in the event it occurs.

Claims (8)

1. A method of treating a cytomegalovirus (CMV) infection in a patient having a CMV infection, the method comprising orally administering to the patient the compound 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole in an amount of 400 mg twice a day.

2. The method of claim 1 , wherein said compound is administered to said patient with food.

3. The method of claim 1 , wherein said compound is administered to said patient without food.

4. The method of claim 1 , wherein said compound is administered as a composition comprising a therapeutically acceptable adjuvant, excipient, or carrier medium.

5. The method of claim 4 , wherein said composition is an immediate release formulation.

6. The method of claim 1 , wherein said compound is administered to said patient in a fasted condition wherein the patient does not consume food during the period from 12 hours before to 3 hours after the administration.

7. The method of claim 1 , wherein said compound is administered to said patient in a fasted condition wherein the patient does not consume food during the period from 6 hours before to 2 hours after the administration.

8. The method of claim 1 , wherein said compound is administered to said patient in a fasted condition wherein the patient does not consume food during the period from 3 hours before to 1 hour after the administration.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 25, 2025
From: PEABODY, JOHN D., III
To: VIROPHARMA INCORPORATED
Reel/Frame 070621/0177 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 25, 2025
From: SHIRE VIROPHARMA LLC
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 070621/0308 →
CHANGE OF NAME Recorded Mar 25, 2025
From: VIROPHARMA INCORPORATED
To: SHIRE VIROPHARMA INCORPORATED
Reel/Frame 070627/0546 →
CHANGE OF NAME Recorded Mar 25, 2025
From: SHIRE VIROPHARMA INCORPORATED
To: SHIRE VIROPHARMA LLC
Reel/Frame 070627/0549 →
Continuity (10)
Continuation 18597197 · Mar 6, 2024
Continuation 18200636 · May 23, 2023
Division 16983310 · Aug 3, 2020
Division 16663743 · Oct 25, 2019
Division 15291639 · Oct 12, 2016
Division 15055043 · Feb 26, 2016
Continuation 14595548 · Jan 13, 2015
Continuation 13282501 · Oct 27, 2011
Provisional Application 61407637 · Oct 28, 2010
Related Publication 20240424009A1 · Dec 26, 2024
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Cited By (1)
US 12,661,368