IP Library › Granted Patent US 12,245,586
Granted Patent B2
US 12,245,586 · App. 18/922,009 · Granted Mar 11, 2025

System for hypothermic transport of samples

Inventors: Lisa Maria Anderson (Cambridge, MA); Jared Alden Judson (Medford, MA)
Assignee: Paragonix Technologies, Inc.
A01N1/126A01N1/143C12M45/22
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Quick Facts
Patent No.
US 12,245,586
App. No.
18/922,009
Granted
Mar 11, 2025
Kind
B2
Abstract

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

Claims (38)

1. A system for hypothermic transport of an organ, comprising:

a transport container comprising a floor and a plurality of walls;

eutectic cooling blocks configured to be arranged within an interior of the transport container,

wherein the eutectic cooling blocks are configured to be arranged within recesses positioned along inside surfaces of the interior of the transport container;

a basket configured to support the organ, wherein the basket is configured to be disposed within the interior of the transport container, the basket corresponding in size and shape to a perimeter of the interior of the transport container such that lateral movement of the basket is limited, the basket comprising a plurality of vertically extending ribs configured to secure the basket to inside surfaces of the plurality of walls of the transport container, the plurality of vertically extending ribs configured to abut the inside surfaces of the plurality of walls of the transport container; and

a lid configured to couple with the plurality of walls to form an insulated environment within the transport container,

wherein the eutectic cooling blocks are configured to maintain a temperature within the interior of the transport container within a target range during transport.

2. The system of claim 1 , further comprising:

a temperature sensor configured to measure a temperature within the interior of the transport container; and

a display outside the insulated environment, the display configured to display the temperature within the interior of the transport container without opening the lid.

3. The system of claim 1 , wherein the eutectic cooling blocks are configured to maintain the temperature within the interior of the transport container within the target range for greater than 4 hours.

4. The system of claim 1 , wherein the eutectic cooling blocks are configured to maintain the temperature within the interior of the transport container within the target range for greater than 8 hours.

5. The system of claim 1 , wherein the target range is a temperature of 2-8° C.

6. The system of claim 1 , wherein the target range is a temperature of 2-10° C.

7. The system of claim 1 , wherein the organ is a lung.

8. The system of claim 1 , further comprising:

a retractable handle external to the transport container; and

wheels external to the transport container.

9. The system of claim 1 , wherein the transport container comprises a floor and four walls and the recesses comprise slots positioned along inside surfaces of the four walls, wherein each slot is configured to receive a eutectic cooling block.

10. The system of claim 1 , wherein the transport container is configured to provide an alert when the temperature within the interior of the transport container measured using the temperature sensor is outside of the target range.

11. The system of claim 1 , wherein the basket comprises a support portion and an insert.

12. The system of claim 11 , wherein the support portion is configured to be positioned inside the insert.

13. A container for transporting an organ, comprising:

a transport container comprising a floor and a plurality of walls;

eutectic cooling blocks configured to be arranged within an interior of the transport container,

wherein the eutectic cooling blocks are configured to be arranged within recesses positioned along inside surfaces of the interior of the transport container;

a basket configured to support the organ, wherein the basket is configured to be disposed within the interior of the transport container, the basket corresponding in size and shape to a perimeter of the interior of the transport container such that lateral movement of the basket is limited, the basket comprising a plurality of vertically extending ribs configured to secure the basket to inside surfaces of the plurality of walls of the transport container, the plurality of vertically extending ribs configured to abut the inside surfaces of the plurality of walls of the transport container; and

a lid configured to couple with the plurality of walls to form an insulated environment within the transport container,

wherein the eutectic cooling blocks are configured to maintain a temperature within the interior of the transport container within a target range during transport.

14. The container of claim 13 , further comprising:

a temperature sensor configured to measure a temperature within the interior of the transport container; and

a display outside the insulated environment, the display configured to display the temperature within the interior of the transport container without opening the lid.

15. The container of claim 13 , wherein the eutectic cooling blocks are configured to maintain the temperature within the interior of the transport container within the target range for greater than 4 hours.

16. The container of claim 13 , wherein the target range is a temperature of 2-10° C.

17. The container of claim 13 , wherein the organ is a lung.

18. The container of claim 13 , wherein the transport container comprises a floor and four walls and the recesses comprise slots positioned along inside surfaces of the four walls, wherein each slot is configured to receive a eutectic cooling block.

19. The container of claim 13 , wherein the basket comprises a support portion and an insert.

20. The container of claim 19 , wherein the support portion is configured to be positioned inside the insert.

Continuity (12)
Continuation 18773382 · Jul 15, 2024
Division 18322458 · May 23, 2023
Continuation 17734587 · May 2, 2022
Continuation 17465322 · Sep 2, 2021
Continuation In Part 16542050 · Aug 15, 2019
Continuation In Part 15870209 · Jan 12, 2018
Continuation 14378034
Continuation 13572315 · Aug 10, 2012
Continuation In Part 13420962 · Mar 15, 2012
Provisional Application 61541425 · Sep 30, 2011
Provisional Application 61452917 · Mar 15, 2011
Related Publication 20250040537A1 · Feb 6, 2025
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