Granted Patent
B2
US 12,376,989 · App. 18/980,347 · Granted Aug 5, 2025
Drug eluting ocular implants and methods of treating an ocular disorder
Inventors:
David S. Haffner (Mission Viejo, CA); Kenneth M. Curry (Oceanside, CA); Harold A. Heitzmann (Irvine, CA); David Applegate (Laguna Hills, CA)
Assignee:
Glaukos Corporation
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Loading inventors, assignments & file history…
Abstract
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Claims (29)
1. A method of implanting a drug delivery ocular implant, the method comprising:
inserting a delivery instrument releasably holding a drug delivery implant into an anterior chamber of an eye, the drug delivery implant having travoprost stored within a reservoir of the drug delivery implant;
advancing the delivery instrument through the anterior chamber of the eye towards a trabecular meshwork;
using the delivery instrument, affixing an anchor into scleral tissue, wherein a first end of the drug delivery implant configured to elute the travoprost is positioned within the anterior chamber of the eye;
releasing the drug delivery implant from the delivery instrument; and
removing the delivery instrument from the eye.
2. The method of claim 1 , wherein inserting the delivery instrument further comprises inserting the delivery instrument through an incision made on a temporal side of the eye.
3. The method of claim 2 , wherein the incision is a self-sealing corneal incision.
4. The method of claim 1 , wherein affixing the anchor into the scleral tissue further comprises positioning the anchor through the trabecular meshwork.
5. The method of claim 1 , wherein affixing the anchor into the scleral tissue further comprises positioning at least a portion of the anchor into Schlemm's canal.
6. The method of claim 1 , wherein at least one of the inserting, advancing, and affixing is performed using a gonioscope.
7. The method of claim 1 , wherein the drug delivery ocular implant comprises a permeable or semi-permeable membrane configured to at least partially control a rate of elution of the travoprost.
8. The method of claim 1 , wherein the delivery instrument comprises an elongate tip.
9. The method of claim 1 , further comprising injecting a viscoelastic into the eye.
10. A method of implanting a drug delivery ocular implant, the method comprising:
inserting a delivery instrument releasably holding the drug delivery ocular implant into an eye, the drug delivery ocular implant comprising a drug stored within a reservoir of the drug delivery ocular implant;
advancing the delivery instrument through an anterior chamber of the eye towards a trabecular meshwork;
using the delivery instrument, anchoring an anchor extending from a first end of the drug delivery ocular implant into an ocular tissue, wherein an opening at a second end of the drug delivery ocular implant configured to elute the drug is positioned within an anterior chamber of the eye;
releasing the drug delivery ocular implant from the delivery instrument; and
removing the delivery instrument from the eye.
11. The method of claim 10 , wherein the drug is travoprost.
12. The method of claim 10 , wherein the drug is an anti-glaucoma medication.
13. The method of claim 10 , wherein the drug is stored within the reservoir prior to inserting the delivery instrument.
14. The method of claim 10 , wherein inserting the delivery instrument further comprises inserting the delivery instrument through an incision made on a temporal side of the eye.
15. The method of claim 14 , wherein the incision is a self-sealing corneal incision.
16. The method of claim 10 , wherein anchoring the anchor further comprises anchoring the anchor through the trabecular meshwork.
17. The method of claim 10 , wherein the ocular tissue is a portion of a sclera.
18. The method of claim 10 , wherein the drug delivery ocular implant comprises a permeable or semi-permeable membrane configured to at least partially control a rate of elution of the drug.
19. The method of claim 10 , further comprising injecting a viscoelastic into the eye.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 30, 2025
From: DOSE MEDICAL CORPORATION
To: GLAUKOS CORPORATION
Reel/Frame 070066/0322 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 29, 2025
From: HAFFNER, DAVID; CURRY, KEN; HEITZMANN, HAROLD; APPLEGATE, DAVID
To: DOSE MEDICAL CORPORATION
Reel/Frame 070047/0105 →
Continuity (9)
Continuation
13321144
Provisional Application
61264594
· Nov 25, 2009
Provisional Application
61264604
· Nov 25, 2009
Provisional Application
61264615
· Nov 25, 2009
Provisional Application
61220527
· Jun 25, 2009
Provisional Application
61179332
· May 18, 2009
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