IP Library › Granted Patent US 12,543,729
Granted Patent B2
US 12,543,729 · App. 19/234,966 · Granted Feb 10, 2026

System for hypothermic transport of samples

Inventors: Lisa Maria Anderson (Cambridge, MA); Jared Alden Judson (Medford, MA)
Assignee: Paragonix Technologies, Inc.
A01N1/126A01N1/143C12M45/22
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Quick Facts
Patent No.
US 12,543,729
App. No.
19/234,966
Granted
Feb 10, 2026
Kind
B2
Abstract

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

Claims (39)

1 . A method of storing a donor organ that has been removed from an organ donor prior to implantation into an organ recipient comprising:

placing a donor organ into a portable storage container, wherein the portable storage container is configured to receive a basket configured to support the donor organ, the basket corresponding in size and shape to a perimeter of an interior of the portable storage container such that lateral movement of the basket is limited when the basket is positioned in the portable storage container,

wherein the basket comprises a plurality of surfaces configured to secure the basket with respect to the interior of the portable storage container, the plurality of surfaces comprising:

a support surface configured to support the donor organ;

a plurality of substantially horizontal surfaces protruding laterally from one or more sides of the basket and configured to be positioned lower than a rim of the portable storage container; and

a plurality of substantially vertical surfaces extending upwardly relative to the support surface;

placing at least one cooling pack in the portable storage container, wherein the at least one cooling pack is configured to maintain a temperature within the portable storage container of between about 2 degrees C. and about 10 degrees C. during storage of the donor organ; and

storing the donor organ in the portable storage container prior to transplanting the donor organ into the organ recipient.

2 . The method of claim 1 , wherein organ preservation solution is stored in the portable storage container.

3 . The method of claim 1 , further comprising flushing the donor organ with organ preservation solution.

4 . The method of claim 1 , wherein the donor organ is maintained at a temperature of 8 to 10 degrees C. within the portable storage container during storage.

5 . The method of claim 1 , further comprising performing ex-vivo perfusion on the donor organ.

6 . The method of claim 1 , wherein the at least one cooling pack is configured to be positioned in thermal communication with the donor organ through a thermal communication passage.

7 . The method of claim 1 , wherein the portable storage container is configured to maintain a temperature of the donor organ around 10 degrees C. for 8 hours.

8 . The method of claim 1 , wherein the portable storage container is configured to maintain a temperature of the donor organ between 4 degrees C. and 10 degrees C. for 8 hours.

9 . The method of claim 1 , wherein the donor organ is a heart.

10 . The method of claim 1 , wherein the donor organ is a lung.

11 . A method of transporting an organ from a donor site to a transplant site comprising:

transporting an organ from the donor site to the transplant site inside an apparatus, wherein the apparatus comprises:

a portable storage container;

a basket configured to support the organ and limit movement of the organ during transportation,

wherein the basket corresponds in size and shape to a perimeter of an interior of the portable storage container such that lateral movement of the basket is limited when the basket is positioned in the portable storage container,

wherein the basket comprises a plurality of edges protruding laterally from one side of the basket such that the plurality of edges are substantially co-planar; and

wherein the plurality of edges are configured to secure the basket to an inside surface of the portable storage container;

a temperature monitor comprising a temperature probe configured to be in the portable storage container;

at least one cooling pack comprising a phase-change material; and

a removable lid configured to be held closed by latches;

wherein the apparatus is configured to maintain a temperature within the portable storage container between 2 degrees C. and 10 degrees C.

12 . The method of claim 11 , wherein the apparatus is configured to maintain a temperature of the organ between 2 degrees C. and 10 degrees C. for 4 hours.

13 . The method of claim 11 , further comprising placing an organ preservation solution into at least one organ container.

14 . The method of claim 11 , further comprising communicating with the temperature monitor of the apparatus using a networked device.

15 . The method of claim 14 , further comprising transmitting, by the networked device, temperatures of the portable storage container.

16 . The method of claim 14 , further comprising determining, by the networked device, that a temperature inside the portable storage container exceeds a predetermined threshold and providing a notification on the networked device.

17 . The method of claim 11 , wherein the at least one cooling pack is configured to be positioned in thermal communication with the organ through a thermal communication passage.

18 . The method of claim 11 , wherein the apparatus is configured to maintain a temperature of the organ around 10 degrees C. for 8 hours.

19 . The method of claim 11 , further comprising flushing the organ with organ preservation solution.

20 . The method of claim 11 , wherein the portable storage container is configured to maintain a temperature of the organ between 4 degrees C. and 10 degrees C. for 8 hours.

21 . The method of claim 11 , wherein the organ is a donor heart.

22 . The method of claim 11 , wherein the organ is a donor lung.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2025
From: ANDERSON, LISA MARIA; JUDSON, JARED ALDEN
To: PARAGONIX TECHNOLOGIES, INC.
Reel/Frame 071963/0259 →
Continuity (13)
Continuation 18791944 · Aug 1, 2024
Continuation 18676273 · May 28, 2024
Continuation 18322458 · May 23, 2023
Continuation 17734587 · May 2, 2022
Continuation 17465322 · Sep 2, 2021
Continuation In Part 16542050 · Aug 15, 2019
Continuation In Part 15870209 · Jan 12, 2018
Continuation 14378034
Continuation 13572315 · Aug 10, 2012
Continuation In Part 13420962 · Mar 15, 2012
Provisional Application 61541425 · Sep 30, 2011
Provisional Application 61452917 · Mar 15, 2011
Related Publication 20250302032A1 · Oct 2, 2025
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