Phosphonate compounds
View Patent ↗The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
1. A compound consisting a phosphonate monoester formed by a covalent linking of tenofovir to a (C 1 -C 24 )alkylpropanediol or (C 1 -C 24 )alkoxypropan-1-ol, or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein tenofovir is covalently linked to hexadecyloxypropan-1-ol.
3. The compound of claim 1 , wherein the compound has the structure:
or a pharmaceutically acceptable salt thereof.
4. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
5. A method for the treatment of a viral disease selected from human immunodeficiency virus, influenza, herpes simplex virus, human herpes virus, cytomegalovirus, hepatitis B and C virus, Epstein-Barr virus, varicella zoster virus, orthopox virus, ebola virus and papilloma virus comprising administering an effective amount of a compound optionally in a pharmaceutically acceptable carrier, wherein the compound comprises a phosphonate ester formed by a covalent linking of tenofovir to an alkylpropanediol or alkoxyalkanol, or a pharmaceutically acceptable salt thereof.
6. The method of claim 5 , wherein tenofovir is covalently linked to hexadecyloxypropan-1-ol.
7. The method of claim 5 wherein the virus is an orthopox virus selected from the group consisting of variola major and minor, vaccinia, smallpox, cowpox, camelpox and monkeypox.
8. The method of claim 5 , wherein the virus is human immunodeficiency virus.
9. The method of claim 5 , wherein the virus is influenza.
10. The method of claim 5 , wherein the virus is herpes.
11. The method of claim 5 , wherein the virus is cytomegalovirus.
12. The method of claim 5 , wherein the virus is hepatitis B.
13. The method of claim 5 , wherein the virus is hepatitis C.
14. The method of claim 5 , wherein the virus is Epstein-Barr virus.
15. The method of claim 5 , wherein the virus is varicella zoster virus.
16. The method of claim 5 , wherein the virus is papilloma.
17. The method of claim 5 , wherein said compound has the structure:
or a pharmaceutically acceptable salt thereof.