Heterocyclic sulfonamides
Provided is a compound of the following formula: wherein: R 3 is an aryl or heteroaryl group, which is optionally substituted with a halogen, lower alkoxy, aryl or heteroaryl group; R 4 is halogen; R 5 is hydrogen, halogen, hydroxy, or lower alkyl; R 6 and R 7 are independently selected from hydrogen, halogen, hydroxy, and lower alkyl; and R 8 is hydrogen, alkyl, halogen, hydroxy, alkoxy, alkylenedioxy, carboxy, acyloxy, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, cyano, acyl, oxo, nitro, amino, sulfanyl, sulfinyl, sulfonyl, aminosulfonyl, amidino, phenyl, benzyl, heteroaryl, heterocyclyl, aryloxy, arallkoxy, heteroaryloxy, or heteroaralkoxy, wherein the amino(s) in the alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, amino, or aminosulfonyl is optionally substituted with alkyl; or a pharmaceutically acceptable salt thereof.
1. A compound of the following formula:
wherein:
R 3 is an aryl or heteroaryl group, which is optionally substituted with a halogen, lower alkoxy, aryl or heteroaryl group;
R 4 is halogen;
R 5 is hydrogen, halogen, hydroxy, or lower alkyl;
R 6 and R 7 are independently selected from hydrogen, halogen, hydroxy, and lower alkyl; and
R 8 is hydrogen, alkyl, halogen, hydroxy, alkoxy, alkylenedioxy, carboxy, acyloxy, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, cyano, acyl, oxo, nitro, amino, sulfanyl, sulfinyl, sulfonyl, aminosulfonyl, amidino, phenyl, benzyl, heteroaryl, heterocyclyl, aryloxy, arallkoxy, heteroaryloxy, or heteroaralkoxy, wherein the amino(s) in the alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, amino, or aminosulfonyl is optionally substituted with alkyl;
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is a phenyl, isoxazolyl, oxazolyl, pyridinyl, pyrazinyl, pyrimidinyl, tetrazol-5-yl, thiazolyl, thiadiazolyl or imidazolyl group, which is optionally substituted with a halogen, lower alkoxy, aryl or heteroaryl group.
3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is an [1,3,4]thiadiazol-2-yl group which is optionally substituted with a phenyl group.
4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is 5-phenyl-[1,3,4]thiadiazol-2-yl.
5. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein
R 4 is chloro; and
R 5 , R 6 and R 7 are hydrogen.
6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is a 1H-imidazol-2-yl group.
7. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein
R 4 is chloro; and
R 5 , R 6 and R 7 are hydrogen.
8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is oxazol-2-yl.
9. The compound of claim 8 , or a pharmaceutically acceptable salt thereof, wherein
R 4 is chloro; and
R 5 , R 6 and R 7 are hydrogen.
10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
R 4 is chloro; and
R 5 , R 6 and R 7 are hydrogen.
11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 8 is hydrogen, N-methyl-N-acetyl-amino, N-(t-butoxycarbonyl)-N-methylamino, N-(Dimethylaminocarbonyl)-N-methylamino, N-(3-methylbutyrl)-N-methylamino, N-(Propoxycarbonyl)-N-methylamino, N-(i-propoxycarbonyl)-N-methylamino, N-butyryl-N-methylamino, N-(ethoxycarbonyl)-N-methylamino, N-(Ethoxycarbonyl)amino, N-(isopropoxycarbonyl)amino, or N-(methoxycarbonyl)amino.
12. A pharmaceutical formulation comprising a pharmaceutically accepted excipient and a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.