Wound and mucous membrane disinfectant
Aqueous wound and mucous membrane disinfectant containing a) octenidine dihydrochloride, and b) one or more active ingredients selected from the group ethanol, 1-propanol, 2-propanol, undecylene amidopropyl trimonium methosulfate, 3-(4-chlorophenoxy)-1,2-propanediol and/or sodium hydroxymethylglycinate and c) glycerin and/or 1,2-diols having 3 to 10 carbon atoms, and d) optionally surfactants, emulsifiers, solubilizers, pH regulators, dyestuffs, perfumes and/or thickeners, the agent being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids.
1. A method to disinfect an open wound or mucous membrane while minimizing irritation to the wound or membrane site, comprising the steps of
A. applying to the site of an open wound or mucous membrane a microbiocidally effective amount of an aqueous composition comprising
(a) from 0.05% to 0.2% by weight of octenidine dihydrochloride;
(b) one or more of
(i) from 0.5% to 15.0% by weight of one or more of 1-propanol, 2-propanol and ethanol
(ii) from 0.5% to 5.0% by weight of undecylene amidopropyl trimoniun methosulfate
(iii) from 0.05% to 0.5% by weight of sodium hydroxymethylglycinate and
(iv) from 0.03% to 0.3% by weight of 3-(4-chlorophenoxy)-1,2-propanediol;
(c) from 0.2 to 3.0% by weight of at least one of glycerin and a 1,2-diol, and
(d) optionally, aqueous sodium hydroxide or phosphoric acid,
wherein the composition is free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids, and has a pH value of from 5 to 7; and
B. allowing the composition to remain on the site until the site is disinfected, wherein the site tolerates the composition with minimal irritation.
2. The method of claim 1 , wherein (b) is one or both of ethanol and 1-propanol.
3. The method of claim 1 , wherein (c) is at least one of glycerin, 1,2-propanediol, 1,2-butanediol, 1,2-pentanediol and 1,2-hexanediol.
4. The method of claim 1 , wherein the disinfectant consists essentially of
(a) from 0.05% to 0.2% by weight of octenidine dihydrochloride;
(b) one or more of
(i) from 0.5% to 15.0% by weight of one or more of 1-propanol, 2-propanol and ethanol
(ii) from 0.5% to 5.0% by weight of undecylene amidopropyl trimoniun methosulfate
(iii) from 0.05% to 0.5% by weight of sodium hydroxymethylglycinate and
(iv) from 0.03% to 0.3% by weight of 3-(4-chlorophenoxy)-1,2-propanediol;
and
(c) from 0.2 to 3.0% by weight of at least one of glycerin and a 1,2-diol, and
(d) optionally, aqueous sodium hydroxide or phosphoric acid,
the disinfectant being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids,
wherein the disinfectant has a pH value of from 5 to 7.
5. The method of claim 1 , wherein the disinfectant comprises
(a) from 0.05% to 0.15% by weight of octenidine dihydrochloride;
(b) from 3.0% to 12.0% by weight of ethanol;
(c) from 0.3% to 1.0% by weight of glycerin (85% by weight); and
(d) water to 100% by weight.
6. The method of claim 1 , wherein the disinfectant comprises
(a) from 0.05% to 0.15% by weight of octenidine dihydrochloride;
(b) from 2.0% to 6.0% by weight of 1-propanol;
(c) from 0.3% to 1.0% by weight of glycerin (85% by weight); and
(d) water to 100% by weight.)
7. The method of claim 1 , wherein the disinfectant is applied as a liquid.
8. The method of claim 1 , wherein the disinfectant is applied to an open wound or mucous membrane as an aqueous solution, as a gel, as an impregnation solution for wipes and/or bandages, or as an aqueous phase of an emulsion.
9. The method of claim 8 , wherein the emulsion contains an oil phase comprising natural oils, modified oils and/or fats.
10. The method of claim 1 , wherein the disinfectant is applied in a cream, lotion or a spray.