Biocompatible polyacrylate compositions for medical applications

1. A medical article comprising an implantable medical device and a coating deposited on at least a part of the device, the coating comprising:

(a) a structural component comprising a linear acrylic homopolymer or linear acrylic copolymer; and

(b) a biobeneficial component comprising a copolymer having an acrylate moiety and a biobeneficial moiety;

wherein the copolymer composing the biobeneficial component has the formula:

wherein

(a) m 1 , n 1 , p 1 , r 1 , m 2 , n 2 , p 2 , and r 2 are all integers;

(b) m 1 ≧0, n 1 >0, p 1 ≧0, r 1 >0; m 2 ≧0, n 2 >0, p 2 ≧0, r 2 >0; and

(c)

(i) if m 1 =0, then p 1 >0;

(ii) if p 1 =0, then m 1 >0; and

(iii) if m 2 =0, then p 2 >0; and

(iv) if p 2 =0, then m 2 >0; and

(v) r 1 and r 2 are the same or different;

(vi) m 1 and m 2 are the same or different;

(vii) n 1 and n 2 are the same or different; and

(viii) p 1 and p 2 are the same or different;

(d) X is hydrogen or methyl group;

(e) each of R, R 1 , and R 2 , independently, is methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; and

(f) Q is a fragment providing the copolymer with biobeneficial properties.

2. The medical article of claim 1 , wherein the medical device is a stent.

3. The medical article of claim 1 , wherein the mass ratio between the structural component and the biobeneficial component is between about 99:1 and about 1:1.

4. The medical article of claim 1 , wherein the acrylic homopolymer or linear acrylic copolymer has the structure:

wherein

(a) X is hydrogen or methyl group;

(b) each of R and R 1 is independently methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl;

(c) m is a positive integer; and

(d) n is 0 or a positive integer.

5. The medical article of claim 1 , wherein Q is derived from poly(alkylene glycols), superoxide dismutate-mimetics (SODm), diazenium diolate type nitric oxide donors, polycationic peptides, polysaccharides, pyrrolidone, vitamin E, sulfonated dextrane, β-phenoxyethanol, N,N-dimethylamino-2-ethanol, mannose-6-phosphate, sulfonic acid, derivatives of sulfonic acid, or mixtures thereof.

6. The medical article of claim 5 , wherein the polycationic peptides are poly(L-arginine), poly(D-arginine), poly(D,L-arginine), poly(L-lysine), poly(D-lysine), poly(δ-guanidino-α-aminobutyric acid), a racemic mixture of poly(L-arginine) or poly(D-arginine), or mixtures thereof.

7. The medical article of claim 5 , wherein the polysaccharides are heparin or derivatives thereof, glycosaminoglycans, keratan sulfate, chondroitin sulfate, dermatan sulfate, hyaluronic acid, hyaluronates, or mixtures thereof.

8. The medical article of claim 5 , wherein the derivatives of heparin are heparinoids, heparin having a hydrophobic counterion, heparan sulfate, heparin salts, or mixtures thereof.

9. The medical article of claim 5 , wherein the derivatives of sulfonic acid are propanesulfonic acid, 2-methyl-1-propanesulfonic acid, benzenesulfonic acid, 3-methoxy-2-hydroxypropanesulfonic acid, or mixtures thereof.