Levalbuterol salt
Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.
1. An aerosol formulation comprising
(a) crystalline levalbuterol L-tartrate,
(b) ethanol, and
(c) a propellant,
wherein particles comprising crystalline levalbuterol L-tartrate from the formulation have a mass median aerodynamic diameter from 1 to 10 microns as measured by an Andersen Cascade Impactor, wherein the crystalline levalbuterol L-tartrate is in the form of needle-like particles, wherein the crystalline levalbuterol L-tartrate is in the form of needle-like particles.
2. The aerosol formulation of claim 1 , wherein the particles comprising crystalline levalbuterol L-tartrate have a mass median aerodynamic diameter of from 1 to 5 microns.
3. The aerosol formulation of claim 1 , wherein ethanol is present in an amount up to 10% by weight of the aerosol formulation.
4. The aerosol formulation of claim 3 , wherein ethanol is present in an amount from 2% to 6% by weight of the aerosol formulation.